Usefulness of new and traditional serum biomarkers in children with suspected appendicitis

Benito, Javier; Acedo, Yordana; Medrano, Lara; Bárcena, Eduardo; Garay, Raquel Pérez; Arana-Arri, Eunate

doi:10.1016/j.ajem.2016.02.011

Cited by 48 publications

(32 citation statements)

References 31 publications

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“…to improve their accuracy and minimize inconsistencies in data acquisition. If an article did not provide adequate data to reproduce two‐by‐two tables it was excluded from the review . We also excluded any article that did not mention “emergency department,” “ED,” or “emergency room” as their study setting or trials that included pre‐ or post‐appendectomy, admitted, or referral patients .…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Accuracy of History, Physical Examination, Laboratory Tests, and Point‐of‐care Ultrasound for Pediatric Acute Appendicitis in the Emergency Department: A Systematic Review and Meta‐analysis

Benabbas

Hanna

Shah

et al. 2017

Academic Emergency Medicine

160

101

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Presence of AA is more likely in patients with undifferentiated abdominal pain migrating to the RLQ or when cough/hop pain is present in the physical examination. Once AA is suspected, no single history, physical examination, laboratory finding, or score attained on PAS can eliminate the need for imaging studies. Operating characteristics of ED-POCUS are similar to those reported for RUS in literature for diagnosis of AA. In ED patients suspected of AA, a positive ED-POCUS is diagnostic and obviates the need for CT or MRI while negative ED-POCUS is not enough to rule out AA.

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Section: Resultsmentioning

confidence: 99%

Diagnostic Accuracy of History, Physical Examination, Laboratory Tests, and Point‐of‐care Ultrasound for Pediatric Acute Appendicitis in the Emergency Department: A Systematic Review and Meta‐analysis

Benabbas

Hanna

Shah

et al. 2017

Academic Emergency Medicine

160

101

View full text Add to dashboard Cite

show abstract

“…History and physical examination are still in the first line, but laboratory tests and imaging modalities are of great importance (5), because especially younger children have limitations in expressing themselves. Complete blood count (CBC) is in the first line of laboratory evaluation to diagnose appendicitis (6,7). White blood cell count (WBC) is studied well in the literature, but recently, there are several CBC parameters such as red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) associated with the diagnosis of appendicitis (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Diagnostic Value of Neutrophil to Lymphocyte Ratio in Pediatric Appendicitis Cases

Yılmaz

Acar

2017

Iran J Pediatr

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“…described a sensitivity of WCC for appendicitis as 19–88% and specificity of 53–100%, and CRP having a sensitivity of 48–75% and specificity of 57–82% . The results were similar to sensitivities and specificities reported by Benito et al ., who also reported a sensitivity of 88% and specificity of 62% for neutrophil counts . Although Benito et al .…”

Section: Discussionmentioning

confidence: 92%

Lymphopaenia in the diagnosis of paediatric appendicitis: a false sense of security?

Greer

Bennett

Wagstaff

et al. 2019

ANZ Journal of Surgery

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Background: Appendicitis is a common indication for emergent surgery in children; however, it is a small proportion of presentations with abdominal pain. As viral illness is a common differential diagnosis, lymphopaenia is used by some as a predictor against appendicitis. Furthermore, neutrophil-lymphocyte ratio (NLR) has been found to predict appendicitis. We aimed to verify if lymphopaenia predicted against appendicitis in children. Methods: Retrospective review was conducted for all patients aged 15 years and under presenting with abdominal pain to our institution in 2017, and data including age, white cell count, neutrophil and lymphocyte count, NLR, C-reactive protein and diagnosis of appendicitis were recorded. Statistical analysis was performed using Stata©. Receiver operating characteristic curves for various tests were formed and areas under curve (AUC) compared using regression, P < 0.05 was considered significant. Results: A total of 1263 patients were presented, of whom 546 had their blood performed and were included, 86 had appendicitis and 460 did not. Neutrophilia was the best predictor for appendicitis (AUC = 0.86), significantly higher than NLR (0.81), P < 0.05. Lymphopaenia was a poor negative predictor of appendicitis (AUC = 0.46), and while isolated lymphopaenia was more predictive (AUC = 0.23) this was inferior to the positive prediction of neutrophilia, P < 0.05. Conclusion: The value of isolated lymphopaenia to predict against appendicitis is largely accounted for inherently normal neutrophils, independently lymphopaenia has little value. NLR, while predictive, is a weaker predictor than neutrophilia.

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Usefulness of new and traditional serum biomarkers in children with suspected appendicitis

Cited by 48 publications

References 31 publications

Diagnostic Accuracy of History, Physical Examination, Laboratory Tests, and Point‐of‐care Ultrasound for Pediatric Acute Appendicitis in the Emergency Department: A Systematic Review and Meta‐analysis

Diagnostic Accuracy of History, Physical Examination, Laboratory Tests, and Point‐of‐care Ultrasound for Pediatric Acute Appendicitis in the Emergency Department: A Systematic Review and Meta‐analysis

Investigation of the Diagnostic Value of Neutrophil to Lymphocyte Ratio in Pediatric Appendicitis Cases

Lymphopaenia in the diagnosis of paediatric appendicitis: a false sense of security?

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