Usefulness of Monoclonal Antibody HIK1083 Specific for Gastric O-glycan in Differentiating Cutaneous Metastasis of Gastric Cancer From Primary Sweat Gland Carcinoma

Iijima, Masayoshi; Nakayama, Jun; Nishizawa, Tomoko; Ishida, Akiko; Ota, Hiroyoshi; Katsuyama, Tsutomu; Saida, Toshiaki

doi:10.1097/dad.0b013e31814691e7

Cited by 8 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histochemical stains reveal positivity for Alcian blue and PAS, whereas immunohistochemical studies demonstrate positive immunoreactivity for CDX2, CK7, CK20, CEA, and EMA. 127 This marker seems to be more specific than CK20, which is positive also in metastatic colorectal cancer, but it is also occasionally expressed in cutaneous metastases from lung and breast. This immunohistochemical marker is specific for gastric O-glycan and it is expressed in gastric mucin glands and gastric cancer cells.…”

Section: Cutaneous Metastases From Gastrointestinal Cancer Colorectalmentioning

confidence: 97%

See 1 more Smart Citation

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

220

104

View full text Add to dashboard Cite

Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

show abstract

Section: Cutaneous Metastases From Gastrointestinal Cancer Colorectalmentioning

confidence: 97%

“…2,107,125 Recently, immunoreactivity for HIK1083 in cutaneous metastasis from gastric carcinoma has also been described. 127 126 This monoclonal antibody stains the signet-ring cells of adenocarcinoma of the stomach but is negative in primary adenocarcinomas of the sweat glands.…”

Section: Cutaneous Metastases From Gastrointestinal Cancer Colorectalmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

220

104

View full text Add to dashboard Cite

show abstract

“… 38 Recently, immunohistochemical analysis has had an important role in identification of primary sites. In our present cases, specific markers for stomach (HIK1083 and MUC5AC), 29 , 43 were used in case 1, and specific markers for breast (estrogen/progesterone receptors and GCDFP15) 2 , 3 , 30 , 44 as well as those for stomach (HIK1083 and MUC6) 29 , 43 were used in case 2. To identify metastasis of gastric carcinoma, carcinoembryonic antigen and cytokeratins 7 and 20 are frequently used.…”

Section: Discussionmentioning

confidence: 99%

“…Because HIK1083 exhibited highly selective reactivity with class III mucins in the gastrointestinal tract, it is considered to be more specific than MUC6. 29 , 43 The estrogen receptor is often present in breast cancers, but >20% of primary gastric cancers also express the estrogen receptor. 2 Our cases together with those in previous reports suggest that HIK1083, GCDFP15, and MUC5AC might be a reasonable combination for use in immunohistochemical analysis in the differential diagnosis of malignant tumors of the breast.…”

Section: Discussionmentioning

confidence: 99%

Breast metastases of gastric signet-ring cell carcinoma: a report of two cases and review of the literature

Iesato¹,

Oba²,

Ono³

et al. 2014

OTT

Self Cite

View full text Add to dashboard Cite

It is occasionally difficult to diagnose breast metastasis of gastric carcinoma because of its rarity. However, to appropriately treat patients with breast tumors without delay, it is important to distinguish metastatic cancer from primary breast cancer. We report two cases of breast metastasis of gastric carcinoma and review the literature. The first case was a 41-year-old female diagnosed with bilateral pelvic tumors who visited the outpatient clinic because of pain and enlargement of both breasts. Ultrasonography showed diffuse hypoechoic lesions, which were enhanced on gadolinium-enhanced magnetic resonance imaging in the bilateral mammary gland. Core needle biopsy of the right breast revealed signet-ring cells, which were also identified in the resected bilateral pelvic tumors. Subsequent upper gastrointestinal endoscopy revealed signet-ring cell carcinoma in the stomach, and the bilateral breast lesions were diagnosed as metastases of gastric carcinoma. The second case was a 34-year-old female diagnosed with cervical metastasis of signet-ring cell carcinoma who was referred to the breast cancer clinic because of a nodule in the left breast detected by computed tomography. Ultrasonography showed a hypoechoic nodule that was enhanced on gadolinium-enhanced magnetic resonance imaging. Because the pathologic findings for the left breast nodule were quite similar to those of gastric cancer and its cervical metastasis, the breast nodule was diagnosed as a metastasis of gastric carcinoma. When a breast tumor is suspected to have metastasized from a primary tumor in another organ, particularly if signet-ring cells are found, the possibility that gastric cancer is present should be considered.

show abstract