Usefulness of hypertriglyceridemia in predicting myocardial infarction late after coronary artery bypass operation

Voors, Adriaan A.; Brussel, Ben L. van; Kelder, Johannes C.; Plokker, H.W. Thijs

doi:10.1016/s0002-9149(97)00138-0

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…Of interest, after CABG, women with high triglyceride levels have far worse long-term survival (HR, 1.5; 95% CI, 1.1-2.1) compared with men with high triglyceride levels (HR, 1.1; 95% CI, 0.9-1.3). Other studies also have demonstrated that elevated triglyceride values after surgery predict vein graft occlusion, 178 recurrent angina and MI, [179][180][181] and the need for redo CABG. 182,183 In a secondary analysis of the Post-CABG Trial, the study investigators demonstrated that a high triglyceride level was a significant prognostic factor for vein graft atherosclerosis progression.…”

Section: Triglyceride Managementmentioning

confidence: 96%

Secondary Prevention After Coronary Artery Bypass Graft Surgery

Kulik¹,

Ruel²,

Jneid³

et al. 2015

Circulation

335

185

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Section: Triglyceride Managementmentioning

confidence: 96%

Secondary Prevention After Coronary Artery Bypass Graft Surgery

Kulik¹,

Ruel²,

Jneid³

et al. 2015

Circulation

335

185

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“…Previous data relating the influence of triglyceride values to post-CABG patients have come from smaller (predominantly male) populations with low diabetic prevalence (18)(19)(20)(21). Triglyceride values have been suggested as predictive of occluded grafts (18), the need for near-term repeat CABG (19), and recurrent angina and MI (20,21).…”

Section: Sprecher and Associatesmentioning

confidence: 99%

“…Triglyceride values have been suggested as predictive of occluded grafts (18), the need for near-term repeat CABG (19), and recurrent angina and MI (20,21). All of these data suggest triglyceride levels are relevant to morbidity but not mortality in men.…”

Section: Sprecher and Associatesmentioning

confidence: 99%

Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis.

Sprecher¹,

Pearce²,

Park³

et al. 2000

Diabetes Care

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A sex analysis O R I G I N A L A R T I C L EOBJECTIVE -Hypertriglyceridemia is commonly observed in association with diabetes. Despite cross-sectional studies and isolated longitudinal analyses in patients without coronary artery disease, the suggestion that triglyceride levels are relevant to subsequent cardiovascular events in the setting of diabetes remains controversial. This study evaluates the predictive value of serum triglyceride levels on mortality in post-coronary artery bypass graft (CABG) diabetic patients with subsequent analysis by sex. RESEARCH DESIGN AND METHODS -This longitudinal observational studyinvolving a large metropolitan hospital consists of 1,172 diabetic post-CABG patients (792 men and 380 women) with lipid data collected between the years 1982 and 1992. Cox proportional hazards regression models were used to estimate the risk of mortality and cardiac events associated with triglyceride levels in the highest quartile (Ͼ2.90 mmol/l for men and Ͼ3.12 mmol/l for women).RESULTS -Elevated preoperative serum triglyceride values in post-CABG subjects with diabetes were correlated with increased overall mortality (hazard ratio [HR] 1.26, 95% CI 1.00-1.59). The greatest influence of triglyceride levels was observed on overall (1.89, 1.30-2.73) and event-free survival (1.49, 1.06-2.08) in women. High triglyceride values were also modestly related to risk of cardiac events in diabetic men (1.28, 0.99-1.66).CONCLUSIONS -These data suggest that increased preoperative triglyceride levels predict increased late mortality and cardiac event risk in diabetic post-CABG patients, more strongly in women than in men.

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“…Hypertriglyceridemia is a well-known risk factor of cardiovascular diseases. 8,9 Obesity, shown by increased body mass index (BMI) and waist-to-hip ratio (WHR), results in various metabolic disorders that raise the risk of atherosclerosis. 10,11 Accumulation of triglyceride-rich lipoproteins has been observed in subjects with abdominal obesity.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular risk factors in males with hypertriglycemic waist (Tehran Lipid and Glucose Study)

et al. 2004

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BACKGROUND: Many studies performed on nontraditional risk factors have proposed a metabolic triad including increased serum level of apolipoprotein B, hyperinsulinemia and high small, dense LDL-C as a risk factor of cardiovascular diseases. Hypertriglycemic waist (increased waist circumference as well as high fasting triglyceride level) can be used as a simple criterion to predict the metabolic triad. The aim of this study was to investigate the prevalence of hypertriglycemic waist and the frequency of cardiovascular risk factors in the affected population. MATERIALS AND METHODS:The study was performed on 4169, 18-70 y-old male subjects of the population of Tehran Lipid and Glucose Study (TLGS). The subjects fell into four groups with respect to serum level of fasting triglycerides (Tg) and waist circumference (WC). Subjects of group 1 had serum Tg Z1.8 mmol/l as well as WC Z95 cm, while those of group 2 had Tg Z1.8 mmol/l and WC o95 cm. The triglycerides level was less than 1.8 mmol/l in groups 3 and 4, whereas WC was Z95 cm and lower than 95 cm, respectively. Cardiovascular risk factors, anthropometric and laboratory variables were compared between the groups. RESULTS: In total, 784 subjects had high serum levels of Tg as well as increased WC. The mean age of subjects was significantly higher in groups 1 and 3 compared to others (37715, 48714, 41 þ 13 and 46713 y of age in groups 4, 3, 2 and 1, respectively, Po0.001). The prevalence of cardiovascular risk factors was significantly higher in group 1 as compared with others. Systolic and diastolic blood pressure, body mass index and WC were significantly higher in group 1 than in the others. Serum total cholesterol, Tg and LDL-C were significantly higher in group 1 compared to others, whereas HDL-C was significantly lower in this group. The prevalence of subjects who had at least four risk factors was 75 and 8% in groups 1 and 4, respectively. CONCLUSION: Hypertriglycemic waist can be used as a simple criterion to predict cardiovascular risk factors.

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Usefulness of hypertriglyceridemia in predicting myocardial infarction late after coronary artery bypass operation

Cited by 9 publications

References 20 publications

Secondary Prevention After Coronary Artery Bypass Graft Surgery

Secondary Prevention After Coronary Artery Bypass Graft Surgery

Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis.

Cardiovascular risk factors in males with hypertriglycemic waist (Tehran Lipid and Glucose Study)

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