Usefulness of high-concentration calcium chloride solution for correction of activated partial thromboplastin time (APTT) in patients with high-hematocrit value

Kanahara, Masaaki; Kai, Hisashi; Okamura, Takashi; Wada, Toyofumi; Suda, Kenji; Imaizumi, Tsutomu; Sagawa, Kimitaka

doi:10.1016/j.thromres.2007.08.004

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…Calcium mediates the binding of the complexes via the terminal gamma-carboxy residues on factor Xa and factor IXa to the phospholipid surfaces expressed by platelets, as well as procoagulant microparticles or microvesicles shed from them [26]. For optimization of calcium chloride concentration, 0.020, 0.025, 0.030 and 0.040 mol/L of calcium chloride solution were used for the clotting time measurement.…”

Section: Resultsmentioning

confidence: 99%

Detection of Fibrinogen and Coagulation Factor VIII in Plasma by a Quartz Crystal Microbalance Biosensor

Chen

Ling

2013

Sensors

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A quartz crystal microbalance (QCM) biosensor with nanogram sensitivity has been constructed through a reasonable designing and biological processing of the piezoelectric quartz crystals. Due to its highly sensitivity, real time detection and low cost, the proposed QCM biosensor has a promising potential in blood coagulation research. In the current study, the QCM biosensor was used to determine the activated partial thromboplastin time (APTT) for 120 anticoagulated plasma specimens. A good linear relationship was found in a double-logarithmic plot of APTT versus fibrinogen concentration in the range of 1.58–6.30 g/L. For factor VIII, the detection range by the QCM biosensor is 0.0185–0.111 mg/L. The QCM biosensor results were compared with those obtained by commercial optical coagulometry and a good agreement (correlation coefficient is 0.949 for fibrinogen, and 0.948 for factor VIII) was reached. Furthermore, the QCM determination can be completed within 10 min. Our study suggested that the proposed QCM biosensor could provide for more convenient and time saving operations, which may be useful in clinical situations for rapid monitoring of anticoagulant therapy using small volume (20 μL) plasma specimens.

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Section: Resultsmentioning

confidence: 99%

Detection of Fibrinogen and Coagulation Factor VIII in Plasma by a Quartz Crystal Microbalance Biosensor

Chen

Ling

2013

Sensors

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“…Activated partial thromboplastin times of different samples were tested using automatic coagulation analyzer and APTT testing kits, the results shown in Figure 6. The assembled heparin from TiOHP and TiOHPHR prolonged APTT over 10 s, and the APTT of TiOHPHR was prolonged approximately 20 s which has a certain clinical significance [18] Heparin can be combined with AT III which play a role in the intrinsic coagulation pathway [12]. Thus, heparin and GREDVY polypeptide make Ti based metal material with a certain anti-clotting function.…”

Section: Hemocompatibility-apttmentioning

confidence: 99%

Combined REDV Polypeptide and Heparin onto Titanium Surface for the Hemocompatibility and Selectively Endothelialization

Wang¹

2014

J Cell Sci Ther

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To enhance the blood compatibility and selective endothelialization of the cardiovascular implants simultaneously, in this study, the mixture of REDV polypeptide and heparin was used to modify titanium (Ti) surfaces in virtue of a polylysine layer. Blood compatibility tests revealed that the modified Ti prolonged blood coagulation time compared with Ti surface. Endothelial cells (ECs)/platelets and ECs/smooth muscle cells (SMCs) competed seeding results showed more attached ECs on the modified samples than that on Ti surfaces. Thus, in vitro evaluation indicates that the REDV polypeptide and heparin modified Ti surface kept excellent biocompatibility, which could improve the blood compatibility and selectively promotes the endothelialization simultaneously. We conceive that the cooperation of REDV polypeptide and heparin may provide a promising selection for biomaterials surface modification of vascular implants.

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“…Calcium’s primary function is as a structural component of bone and teeth, blood vessels, nails, and hair. It also participates in hormonal regulation through the activation and secretion of hormones and neurotransmitters [ 1 , 2 ]. However, calcium is reported to play a key role in many technological aspects of food production.…”

Section: Introductionmentioning

confidence: 99%

Effect of Calcium Compound Type and Dosage on the Properties of Acid Rennet Goat’s Milk Gels

2021

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The aim of this study was to determine the effect of adding calcium compounds to processed goat’s milk, and on the properties of acid rennet goat’s milk gels, which are a middle product obtained in the manufacture of acid rennet cheese. The properties of the gels directly affect the quality of acid rennet cheeses. The analysis of raw goat’s milk was carried out, then acid rennet gels were produced with the addition of six different calcium compounds (chloride, citrate, bisglycinate, gluconate, lactate, and carbonate). The dynamics of milk fermentation were performed by monitoring the pH value of milk during acidification. The pH, syneresis, color, and texture profile were determined in the formulated acid rennet gels. An organoleptic evaluation was also performed. The study demonstrated that, not only calcium chloride, but also calcium citrate, gluconate, lactate, bisglycinate, and calcium carbonate could be used in the production of goat’s milk acid rennet gels, or the middle product in the manufacture of acid rennet curd cheese from goat’s milk. Notably, the addition of citrate, bisglycinate, and calcium carbonate in doses of 20 mg Ca 100 g−1 most effectively reduced syneresis compared to the control sample by 4.76% (citrate), 7.85% (bisglycinate), and 10.28% (carbonate). The hardness of the control gels ranged from 2.35 N to 2.99 N. The addition of chloride, citrate, gluconate, lactate, and calcium carbonate to the milk improved the acid rennet gel’s hardness. The addition of 20 mg Ca 100 g−1 as gluconate increased the hardness the most (3.61 N). When increasing the calcium dosage in the form of all compounds, there was a tendency to increase the gel’s springiness. The addition of chloride, citrate, and bisglycinate to milk did not result in a darkening of the gel’s color. The addition of calcium compounds mostly reduced the intensity of goatish taste and odor. Calcium gluconate, in particular, reduced the goatish taste the most, a taste which is not always acceptable by the consumers.

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Usefulness of high-concentration calcium chloride solution for correction of activated partial thromboplastin time (APTT) in patients with high-hematocrit value

Cited by 9 publications

References 4 publications

Detection of Fibrinogen and Coagulation Factor VIII in Plasma by a Quartz Crystal Microbalance Biosensor

Detection of Fibrinogen and Coagulation Factor VIII in Plasma by a Quartz Crystal Microbalance Biosensor

Combined REDV Polypeptide and Heparin onto Titanium Surface for the Hemocompatibility and Selectively Endothelialization

Effect of Calcium Compound Type and Dosage on the Properties of Acid Rennet Goat’s Milk Gels

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