Combined REDV Polypeptide and Heparin onto Titanium Surface for the Hemocompatibility and Selectively Endothelialization

Abstract

To enhance the blood compatibility and selective endothelialization of the cardiovascular implants simultaneously, in this study, the mixture of REDV polypeptide and heparin was used to modify titanium (Ti) surfaces in virtue of a polylysine layer. Blood compatibility tests revealed that the modified Ti prolonged blood coagulation time compared with Ti surface. Endothelial cells (ECs)/platelets and ECs/smooth muscle cells (SMCs) competed seeding results showed more attached ECs on the modified samples than that on Ti surfaces. Thus, in vitro evaluation indicates that the REDV polypeptide and heparin modified Ti surface kept excellent biocompatibility, which could improve the blood compatibility and selectively promotes the endothelialization simultaneously. We conceive that the cooperation of REDV polypeptide and heparin may provide a promising selection for biomaterials surface modification of vascular implants.