Usefulness of grape seed polyphenols in the prevention of skin cancer: A mini review

Kalekhan, Faizan; Bala, Nandakishore; Rao, Suresh; Pais, Michael L.J.; Adnan, Mohammed; Sajan, Simon; Baliga, Manjeshwar Shrinath

doi:10.1016/b978-0-12-816151-7.00009-0

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…Due to their ability to reduce the oxidated LDL in plasma, to protect the mitochondrial system against oxidative stress induced by hydrogen peroxide, to decrease the oxidative stress in serum, and to protect against DNA damage the grape polyphenols are being administered orally. Other applications of polyphenolic extracts from Vitis vinifera L. include their external use for medicinal purposes in skin cancer prevention [ 5 ] or for cosmetic purposes in oral care, to reduce the oxidative stress which is involved in periodontitis pathogenesis [ 6 ], in skin care for antiaging purposes [ 7 ], in skin photoprotection [ 8 ], or to reduce skin pigmentation [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Biological Activities of Canes and Pomace Extracts from Several Varieties of Vitis vinifera L. for Inclusion in Freeze-Drying Mouthwashes

et al. 2022

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In this study, the biological activities of four extracts from Vitis vinifera by-products: two pomace extracts, white (WPE) and red (RPE), a canes extract (CE), and their combination (CoE), were evaluated, to be included in freeze-drying mouthwashes formulations. The cytocompatibility and anticancerous potential of the four extracts were tested on three cancerous cell lines, as well as the cytoprotective activity against nicotine-induced cytotoxicity and the antioxidant potential determined on a human gingival fibroblasts (HGF) cell line. Additionally, the anti-inflammatory activity and the antimicrobial activity against several microorganisms from the oral microbiome were tested. Freeze-dried mouthwashes with CoE were prepared and characterized, both as lyophilizates and after reconstitution. The four tested extracts showed the highest cytotoxicity on MDA-kb2 cell line. The antioxidant potential was demonstrated for WPE, RPE, CE, and CoE, both in non-stimulated and H2O2 stimulated conditions. The four extracts reduced the levels of proinflammatory cytokines (IL-6, IL-8, and IL-1β) in a dose-dependent manner, confirming their anti-inflammatory activity. The antimicrobial activity of tested extracts was shown against pathogenic bacteria from the oral microbiome. Mouthwashes of CoE with poloxamer-407, xylitol, and different ratios of mannitol were prepared by freeze-drying leading to porous formulations with interesting mechanical properties and reconstitution times.

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Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Biological Activities of Canes and Pomace Extracts from Several Varieties of Vitis vinifera L. for Inclusion in Freeze-Drying Mouthwashes

et al. 2022

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“…Grape seeds have high antioxidant capacity according to their rich content of polyphenols, especially flavonols, and proanthocyanidins (Peralbo‐Molina & Luque de Castroa, 2013). Grape seed polyphenols have been associated with positive health benefits including anti‐carcinogenic activity (Kalekhan et al., 2020; Pérez‐Ortiz et al, 2019); antioxidant (Costa et al., 2019), anti‐inflammatory (Yin et al., 2015), anti‐ulcer (Jambi & Khattab, 2019), among others.…”

Section: Introductionmentioning

confidence: 99%

Investigation of textural, functional, and sensory properties of muffins prepared by adding grape seeds to various flours

Yalçın

Özdal

Gök

2021

Food Processing Preservation

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Functional muffins were developed by whole wheat (Triticum aestivum L.), whole siyez wheat (Triticum monococcum L.), and whole oat (Avena sativa L.) flours with grape seed flour (GSF) at 7.5% and 15% ratio which is an important by-product of the food industry. Antioxidant capacities, physicochemical, color, textural, and sensorial properties of muffins were evaluated. Total phenolic contents and antioxidant capacities of muffins were enhanced significantly (p < .05) with GSF addition. Whole oat flour muffins exhibited higher total phenolic contents and antioxidant capacities than others. Hardness and chewiness values (p < .05) of all muffins were significantly different from each other. L, a, and b values were decreased in crumb and crust with increased amounts of GSF. According to sensory analysis results, there were no significant differences (p > .05) between muffins of whole wheat, whole siyez, and whole oat flours. Based on the results, GSF can be used for the enrichment of bakery products to prepare functional food. Practical applicationsThis study has been carried out to produce functional muffins that may provide additional health benefits, besides finding a solution of food waste management. Grape seeds have been associated with positive health effects according to their high antioxidant capacity related to their rich content of polyphenols. The processes of wine, fruit, pekmez, and vinegar produce significant quantities of solid organic waste and by-products, including grape pomace, seed, and skins after pressing the grape. The usage of these valuable by-products in food is important for the reduction of food waste, improvement of public health according to their high antioxidant capacity and sustainability. The present study focuses on total phenolics, antioxidant capacities, physicochemical, color, textural, and sensory properties of functional muffins. To the best of our knowledge, this is the first study that has focused on the effect of adding grape seed flour (in two different doses 7.5% and 15%) for the development of innovative functional muffins produced using different types of flours including whole wheat (Triticum aestivum L.) flour, whole siyez wheat (Triticum monococcum L.) flour, and whole oat (Avena sativa L.

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“…Studies have suggested that topical as well as the dietary feeding of grape seed extracts (resveratrol, quercetin, catechin) had beneficial results in reducing DMBA-induced epidermal hyperplasia, inflammation, and proliferation. The concomitant oral and topical administration have been demonstrated to be more effective than separate use and lead to lower inflammation, oxidative stress, and mutations of Ha-ras in codon 61 [ 28 ].…”

Section: Polyphenols As Anticancer Agentsmentioning

confidence: 99%

Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

Vladu

Ficai

Ene

et al. 2022

IJMS

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Polyphenols represent a structural class of mainly natural organic chemicals that contain multiple phenol structural units. The beneficial properties of polyphenols have been extensively studied for their antitumor, anti-inflammatory, and antibacterial effects, but nowadays, their medical applications are starting to be extended to many other applications due to their prebiotic role and their impact on the microbiota. This review focused on the use of polyphenols in cancer treatment. Their antineoplastic effects have been demonstrated in various studies when they were tested on numerous cancer lines and some in in vivo models. A431 and SCC13 human skin cancer cell lines treated with EGCG presented a reduced cell viability and enhanced cell death due to the inactivation of β-catenin signaling. Additionally, resveratrol showed a great potential against breast cancer mainly due to its ability to exert both anti-estrogenic and estrogenic effects (based on the concentration) and because it has a high affinity for estrogen receptors ERα and Erβ. Polyphenols can be combined with different classical cytostatic agents to enhance their therapeutic effects on cancer cells and to also protect healthy cells from the aggressiveness of antitumor drugs due to their anti-inflammatory properties. For instance, curcumin has been reported to reduce the gastrointestinal toxicity associated with chemotherapy. In the case of 5-FU-induced, it reduced the gastrointestinal toxicity by increasing the intestinal permeability and inhibiting mucosal damage. Co-administration of EGCG and doxorubicin induced the death of liver cancer cells. EGCG has the ability to inhibit autophagic activity and stop hepatoma Hep3B cell proliferation This symbiotic approach is well-known in medical practice including in multiple chemotherapy.

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Usefulness of grape seed polyphenols in the prevention of skin cancer: A mini review

Cited by 6 publications

References 29 publications

In Vitro Evaluation of Biological Activities of Canes and Pomace Extracts from Several Varieties of Vitis vinifera L. for Inclusion in Freeze-Drying Mouthwashes

In Vitro Evaluation of Biological Activities of Canes and Pomace Extracts from Several Varieties of Vitis vinifera L. for Inclusion in Freeze-Drying Mouthwashes

Investigation of textural, functional, and sensory properties of muffins prepared by adding grape seeds to various flours

Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

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