Usefulness of D2‐40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma

Arai, Eiichi; Kuramochi, Akira; Tsuchida, Takaaki; Tsuneyoshi, Masazumi; Kage, Masayoshi; Fukunaga, Masao; Ito, Tomoo; Tada, Toyohiro; Izumi, Mitsuru; Shimizu, Ken; Hirose, Takanori; Shimizu, Michio

doi:10.1111/j.1600-0560.2006.00461.x

Cited by 110 publications

(56 citation statements)

References 29 publications

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“…Thus, it is possible that KHE and TA are part of the same neoplastic spectrum [9,23] . Arai et al [17] reported D2-40 could be a useful antibody for immunohistochemical discrimination between KHE and TA because of the different immunostaining patterns. These differences were limited to the peripheral area of capillary proliferation and surrounding dilated vessels; therefore, it is suggested that KHE and TA may reflect different stages in the evolution of a single entity.…”

Section: Review Of the Literaturementioning

confidence: 98%

“…VEGFR-3 [15] and D2-40 [16,17] are markers recently used for KHEs which are partially lymphothelial differentiated, and can be used to differentiate KHE from other vascular lesions of infancy [16,17] . KHE can occur with or without Kasabach-Merritt phenomenon [18] (KMP), which is marked by severe thrombocytopenia and a variable degree of anemia.…”

Section: Review Of the Literaturementioning

confidence: 99%

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Kaposiform hemangioendothelioma: Case report and literature review

Zhou

Yang

Nie

et al. 2007

Chin. J. Clin. Oncol.

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Section: Review Of the Literaturementioning

confidence: 98%

Section: Review Of the Literaturementioning

confidence: 99%

Kaposiform hemangioendothelioma: Case report and literature review

Zhou

Yang

Nie

et al. 2007

Chin. J. Clin. Oncol.

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“…4 Podoplanin was expressed by some vascular tumors with lymphatic differentiation, such as lymphangioma, Kaposi's sarcoma, Kaposiform hemangioendothelioma (socalled Dabska tumor), hobnail hemangioma, and a subset of angiosarcomas. [5][6][7][8][9][10] However, the expression of podoplanin in liver tumors has not been well documented.…”

mentioning

confidence: 99%

Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver

et al. 2008

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Podoplanin, which is immunoreactive to D2-40 antibody, is reportedly expressed in lymphatic vessels in nonneoplastic tissues, and also in vascular and non-vascular tumors. However, its expression in non-neoplastic and neoplastic liver tissues has not been well documented. In this study, we examined podoplanin expression in specimens from 10 normal livers and 73 cases of liver tumors: hemangioma (16 cases), epithelioid hemangioendothelioma (9 cases), angiosarcoma (4 cases), angiomyolipoma (7 cases), hepatocellular carcinoma (11 cases), intrahepatic cholangiocarcinoma (11 cases), and metastatic liver cancer (15 cases). We compared levels of podoplanin and other endothelial markers (CD31, CD34, and factor VIII) in liver tumors. In the normal liver, podoplanin was expressed in lymphatic endothelium, nerve fibers, and mesothelium in the hepatic capsule, but not observed in any cells within hepatic lobules. Among liver tumors, podoplanin was specifically expressed in seven of nine cases (78%) of epithelioid hemangioendothelioma but not in other hepatic tumors. The expression of CD31, CD34, and factor VIII was observed in endothelial cells in all cases of hemangioma, epithelioid hemangioendothelioma, angiosarcoma, and angiomyolipoma with one exception, a case of epithelioid hemangioendothelioma which was without CD31 expression. Interestingly, the intensity of podoplanin expression was negatively correlated with the expression of CD34 and factor VIII. In conclusion, podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.

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“…It has been proposed that both descend from stem cells that can develop along both blood vessel endothelial and lymphatic lineages. They express endothelial markers such as cluster of differentiation 31 (CD31) and CD34 and lymphatic markers D2-40 and Prospero homeobox protein 1 (PROX1) (Arai et al, 2006). Hence, they display aggregates of epithelioid cells surrounded by malformed lymphatic vessels.…”

Section: Kaposiform Haemangioendotheliomamentioning

confidence: 99%

Textbook of Plastic and Reconstructive Surgery

Butler¹,

Ghali²,

Kalaskar³

2016

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A CIP catalogue record for this book is available from The British Library.This book is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. The user is advised to always check the product information and clinical procedures with the most up-to-date published product information and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or misuse or misapplication of material in this work.ISBN: 978-1-910634-37-0 (Hbk.) ISBN: 978-1-910634-38-7 (Pbk.) ISBN: 978-1-910634-39-4 (PDF) ISBN: 978-1-910634-40-0 (epub) ISBN: 978-1-910634-41-7 (mobi)

show abstract

Usefulness of D2‐40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma

Cited by 110 publications

References 29 publications

Kaposiform hemangioendothelioma: Case report and literature review

Kaposiform hemangioendothelioma: Case report and literature review

Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver

Textbook of Plastic and Reconstructive Surgery

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