Kaposiform hemangioendothelioma: Case report and literature review

Zhou, Gang; Yang, Sen; Nie, Xiu; Du, Jun; Jin, Li; Liu, Jianxiang; Ze, Renhao; He, Yu

doi:10.1007/s11805-007-0289-z

Cited by 5 publications

(8 citation statements)

References 29 publications

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“…KHE usually involves the soft tissues and is often associated with KMP. There are rare reports of bone involvement, such as the case report by Zhou et al [10] with mainly unifocal involvement reported. This is the first case report of bifocal involvement of the tibia without cutaneous changes.…”

Section: Discussionmentioning

confidence: 99%

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Bifocal Tibial Kaposiform Hemangioendothelioma Responsive to Vincristine Therapy: A Case Report

et al. 2019

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Rare co-existance of disease or pathology Background:Kaposiform hemangioendothelioma is a rare locally aggressive vascular endothelial-derived spindle cells neoplasm. Herein, we report a rare case of bifocal tibial kaposiform hemangioendothelioma. Case Report:A 9-year-old female presented with a 2-year history of pain and swelling in the left leg. The patient had a high plasma level of the D-dimer and fibrinogen. Radiography revealed a centric lytic lesion on the left proximal tibial metaphysis and an eccentric lateral distal tibial metaphyseal. Histopathologic examination of the sample taken from the distal tibia revealed a dense spindle cell tumor with lobular architecture composed of compact spindle cells compressing small slit-like vascular spaces, forming glomeruloid nests. No necrosis was identified.Based on these findings and the positive immunohistochemical staining for CD31, CD34, and D2-40, the patient was diagnosed with kaposiform hemangioendothelioma. Treatment was started by using vincristine chemotherapy, after which the patient developed temporary peroneal neuropathy, which improved over the next 3 months. Conclusions:Bifocal tibial kaposiform hemangioendothelioma lesions are unique in pediatric patients and can be successfully treated with vincristine chemotherapy. In these cases, the treating physician should be aware of peroneal neuropathy as a potential complication of vincristine administration.

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Section: Discussionmentioning

confidence: 99%

“…Kaposiform hemangioendothelioma (KHE), a relatively uncommon pathology, has primarily been published in the literature as case reports [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. It is a rare, locally aggressive vascular endothelial-derived spindle cell neoplasm occurring most often in infants and adolescents [1].…”

Section: Introductionmentioning

confidence: 99%

Bifocal Tibial Kaposiform Hemangioendothelioma Responsive to Vincristine Therapy: A Case Report

et al. 2019

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“…Most of the KHEs present with KMP, namely coagulopathic KHE, and cause significant mortality by a deadly haemorrhage [2,9]. KHE generally occurs in the soft tissues, and only rarely has been reported to invade bone [1][2][3][4][5][6][7][8].Of the cases of KHE invasion into bone, only one has been reported in spine [8].…”

Section: Case Reportmentioning

confidence: 99%

“…In the eight cases reporting primary bony involvement, six cases involved surgical excision, whereas prednisone and interferon were used in the other two cases. According to the literature, the better results were obtained with excision [1][2][3][4][5][6][7][8]. Because of its rarity, there are no known treatment guidelines for KHE.…”

Section: Case Reportmentioning

confidence: 99%

“…It most often occurs in the trunk, extremities, and retroperitoneum, although the lesions sometimes occur on the head and neck [1]. Eight cases of KHE have been reported in bone, one of which was located in spine [1][2][3][4][5][6][7][8].We report a unique case of spinal KHE with painless thoracic scoliosis without Kasabach-Merritt phenomenon (KMP) or cutaneous lesions. The patient had been misinterpreted as adolescent idiopathic scoliosis.…”

Section: Introductionmentioning

confidence: 99%

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Kaposiform hemangioendothelioma with adolescent thoracic scoliosis: a case report and review of literature

et al. 2011

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Kaposiform hemangioendothelioma (KHE) is a rare locally aggressive vascular tumor that usually presents as a superficial or deep soft tissue mass with associated cutaneous lesions. We report a unique spinal KHE with painless thoracic scoliosis in a 14-year-old girl. She underwent simultaneous tumor biopsy, spinal deformity correction and fusion. At 3 years follow-up, the patient's MRI showed no significant deterioration of process without any therapy. KHE presenting as scoliosis is rare and to our knowledge this is the first recognized case in the reported world literature.

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Multivertebral Kaposiform hemangioendothelioma presenting as scoliosis - A case report and review of literature

Shyam¹,

Thippeswamy²,

Kamashi³

et al. 2023

Journal of Clinical Orthopaedics and Trauma

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Kaposiform hemangioendothelioma: Case report and literature review

Cited by 5 publications

References 29 publications

Bifocal Tibial Kaposiform Hemangioendothelioma Responsive to Vincristine Therapy: A Case Report

Bifocal Tibial Kaposiform Hemangioendothelioma Responsive to Vincristine Therapy: A Case Report

Kaposiform hemangioendothelioma with adolescent thoracic scoliosis: a case report and review of literature

Multivertebral Kaposiform hemangioendothelioma presenting as scoliosis - A case report and review of literature

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