Usefulness of Assessing Circulating Levels of Resistin, Ghrelin, and IL-18 in Alcoholic Acute Pancreatitis

Daniel, Paul; Leśniowski, Bartosz; Jasińska, Anna; Pietruczuk, Mirosława; Małecka‐Panas, Ewa

doi:10.1007/s10620-009-1106-8

Cited by 23 publications

(15 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum concentrations of various inflammatory markers and mediators, for example, proinflammatory cytokines, procalcitonin, or acute phase proteins, vary between MAP and SAP patients and may help in clinical practice . The severity of AP patients shifted from mild to SAP usually after 24 h of disease admission.…”

Section: Discussionmentioning

confidence: 99%

Elevated Level of miR‐551b‐5p is Associated With Inflammation and Disease Progression in Patients With Severe Acute Pancreatitis

2018

View full text Add to dashboard Cite

Circulating microRNAs have the potential to be noninvasive biomarkers for assessing disease progression. MicroRNA-551b-5p (miR-551b-5p) was previously reported to be differentially expressed in pancreatic patients. The serum miR-551b-5p level was measured in patients with mild acute pancreatitis (MAP), severe acute pancreatitis (SAP), and healthy controls using quantitative real-time polymerase chain reaction (RT-PCR) analysis to evaluate its impact on inflammatory response. Acute Physiology and Chronic Health Evaluation II (APACHE II), Multiple Organ Dysfunction Score (MODS), Sequential Organ Assessment Score (SOFA), and Ranson's scores were recorded. Inflammatory cytokines, IL-6, IL-17, IL-1β, and Tumor Necrosis Factor-α (TNF-α), were detected in serum samples obtained from MAP and SAP patients on admission day 1, day 3, and day 5 using Enzyme Linked Immunosorbent Assay (ELISA). Inflammatory cytokines were analyzed in peripheral blood mononuclear cells (PBMCs), which were transfected with miR-551b-5p-negative controls and inhibitors. The serum miR-551b-5p level was significantly higher in MAP and SAP patients compared to controls (P < 0.001). An elevated miR-551b-5p level is positively associated with APACHE II, MODS, SOFA, and Ranson's scores (P < 0.001). Serum cytokines levels were significantly elevated in MAP and SAP patients compared to controls (P < 0.05). In addition, the level of these inflammatory cytokines was increased in PBMCs of SAP patients in comparison with those of healthy controls (P < 0.05), and this rise was significantly reduced with the addition of an miR-551b-5p inhibitor. In conclusion, serum miR-551b-5p is elevated in patients with MAP and SAP and is involved in the regulation of inflammatory response. It may be a useful biomarker for assessing the severity of SAP.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated Level of miR‐551b‐5p is Associated With Inflammation and Disease Progression in Patients With Severe Acute Pancreatitis

2018

View full text Add to dashboard Cite

show abstract

“…Daniel et al evaluated the serum ghrelin levels in 32 patients with alcoholic AP and in 30 matched controls (32). The serum ghrelin concentrations on the first, third and fifth days of the study were comparable and significantly higher than in the controls.…”

Section: Discussionmentioning

confidence: 99%

Serum Leptin and Ghrelin Levels in Patients in the Early Stages of Acute Biliary Pancreatitis and Different Degrees of Severity

Panek¹,

Bonior²,

Pieton³

et al. 2014

Polish Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…A number of studies reported that ghrelin had anti-inflammatory effects both in vitro and in vivo, and was as a promising therapeutic agent in the treatment of inflammatory diseases and injury 4,27,28 . However, serum levels of ghrelin were increased in various inflammatory diseases in humans and in animal models, such as inflammatory bowel disease 29 , ankylosing spondylitis 30 , sepsis 31 , pancreatitis 32 and arthritis 33 , and increases in ghrelin levels were correlated with the disease severity and the serum levels of proinflammatory cytokines such as TNF-a and IL-6 29,31 . It was hypothesized that the elevation of serum ghrelin levels in inflammatory diseases might be a way to maintain the energy balance by controlling the body's response to systemic inflammation and stress and also to a degree, immune activation 34 .…”

Section: Discussionmentioning

confidence: 99%

Associations between serum ghrelin and knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee osteoarthritis

Wang

et al. 2017

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

Usefulness of Assessing Circulating Levels of Resistin, Ghrelin, and IL-18 in Alcoholic Acute Pancreatitis

Abstract: Serum concentration of IL-18 and resistin may contribute to inflammatory response and may be useful as an early marker of inflammation in AP. We also suspect that ghrelin affects the course of AP and plays an important role in inflammatory response.

Cited by 23 publications

References 47 publications

Elevated Level of miR‐551b‐5p is Associated With Inflammation and Disease Progression in Patients With Severe Acute Pancreatitis

Elevated Level of miR‐551b‐5p is Associated With Inflammation and Disease Progression in Patients With Severe Acute Pancreatitis

Serum Leptin and Ghrelin Levels in Patients in the Early Stages of Acute Biliary Pancreatitis and Different Degrees of Severity

Associations between serum ghrelin and knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee osteoarthritis

Contact Info

Product

Resources

About