Usefulness of AgNOR counts in diagnosing epithelial dysplasia

Ray, Jharna; Chattopadhyay, Amit; Caplan, Daniel J.

doi:10.1034/j.1600-0714.2003.00053.x

Cited by 22 publications

(23 citation statements)

References 16 publications

(25 reference statements)

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“…Our results reaffirm the finding of previous studies, 32,33 that is, an increase in AgNOR counts in dysplastic leukoplakia, compared with non‐dysplastic leukoplakia and NOM. Thus, the AgNOR might be quantitative, discriminative, and easy to monitor routinely in detecting incipient cellular alterations 34 .…”

Section: Discussionsupporting

confidence: 92%

Actual proliferating index in oral squamous cell carcinoma and leukoplakia

Chandak¹,

Gadbail

Chaudhary

et al. 2011

J of Invest & Clin Dent

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Section: Discussionsupporting

confidence: 92%

Actual proliferating index in oral squamous cell carcinoma and leukoplakia

Chandak¹,

Gadbail

Chaudhary

et al. 2011

J of Invest & Clin Dent

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“…Ray et al in their studies on premalignant lesions showed higher mean AgNOR counts in leukoplakia as compared to normal epithelium, [10] which was similar to our study which showed increase in mean AgNOR counts from mild to severe epithelial dysplasia in various leukoplakic lesions. Warnakulasuriya and Johnson also revealed more dispersed counts of AgNOR in all types of dysplasias.…”

Section: Discussionsupporting

confidence: 92%

“…AgNOR have been shown to be replicatory markers. Mean AgNOR count can be useful in diagnosing histological features representing oral leukoplakia and has been shown to correlate with clinical outcomes of various cancers [10]. An obvious feature of all oral cancers is excessive proliferation of oral keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

Silver Binding Nucleolar Organizer Regions Dots in Oral Leukoplakia with Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An In Vivo Study

Sebastian¹,

Singh

Chandra

et al. 2014

ISRN Dentistry

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Silver binding nucleolar organizer regions (AgNOR) in normal oral mucosa (NOM), oral leukoplakia with epithelial dysplasia (ED), and oral squamous cell carcinoma (OSCC) were studied. The mean AgNOR count per nucleus increased from NOM to ED to OSCC. Tissue showing ED in oral leukoplakia and OSCC cases showed higher counts, wider scatter, and smaller size of AgNOR dots in the nuclei. The study seems to suggest that time method has some potential in distinguishing between NOM and oral leukoplakia with ED and OSCC. Studies of larger numbers are needed to arrive at more substantial conclusions.

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“…According to Xie et al (17), the quantitative analysis of NORs may help distinguish a normal epithelium from epithelial dysplasia and oral squamous cell carcinoma. In fact, for Ray et al (18), the quantative analysis of NORs is a useful tool for the definitive diagnosis of epithelial dysplasia. However, according to Elangovan et al (2008) (6), the quantative analysis of NORs is proportional to the cell proliferation rate and not necessarily indicates the malignant transformation potential of a specific lesion, but the morphologic characteristic of NORs may be an important tool in the attempt of differencing hyperplasic, pre-malignant and malignant lesions.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Cell Proliferation Ratio in Oral Lichen Planus, Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Sousa

Paradella²,

Carvalho³

et al. 2009

Med Oral

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http://www.medicinaoral.com/medoralfree01/v14i11/medoralv14i11p563.pdf AbstractBackground: Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. Aim: To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indicate the potential for malignant transformation . Material and Methods: Twenty-four cases of each lesion were submitted to the streptoavidin-biotin and AgNOR technique to evaluate the immunohistochemical expression of PCNA and the mean NORs/nucleus, respectively. Results: Positivity for PCNA was observed in 58.33% of oral lichen planus cases, 83.33% of epithelial dysplasia cases and 91.67% of oral squamous cell carcinoma cases. Chi-squared test showed that the number of positive cases for PCNA was significantly lower in oral lichen planus than in oral squamous cell carcinoma (p<0.05). No significant statistical difference between oral lichen planus and epithelial dysplasia (p>0.05) and between the epithelial dysplasia and oral squamous cell carcinoma (p>0.05) was observed. The mean NORs/nucleus in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma were 1.74±0.32, 2.42±0.62 e 2.41±0.61, respectively. Variance analysis (ANOVA) revealed significant statistical difference between oral lichen planus and the other studied lesions (p<0.05). Conclusion: Oral lichen planus cell proliferation rate was less than in oral epithelial dysplasia and oral squamous cell carcinoma which might explain the lower malignant transformation rate.

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Usefulness of AgNOR counts in diagnosing epithelial dysplasia

Abstract: Mean AgNOR count can be a useful tool in definitive diagnosis of epithelial dysplasia.

Cited by 22 publications

References 16 publications

Actual proliferating index in oral squamous cell carcinoma and leukoplakia

Actual proliferating index in oral squamous cell carcinoma and leukoplakia

Silver Binding Nucleolar Organizer Regions Dots in Oral Leukoplakia with Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An In Vivo Study

Comparative Analysis of Cell Proliferation Ratio in Oral Lichen Planus, Epithelial Dysplasia and Oral Squamous Cell Carcinoma

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