Comparative Analysis of Cell Proliferation Ratio in Oral Lichen Planus, Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Sousa, Fernando Augusto Cervantes Garcia de; Paradella, Thaís Cachuté; Carvalho, Yasmin Rodarte; Rosa, Leonardo Cruz da

doi:10.4317/medoral.14.e563

Cited by 25 publications

(34 citation statements)

References 17 publications

(17 reference statements)

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“…In this study, Ki67LI in group B was less than that of in group C, which might indicate less growth potential in OLP lesions, possibly indicating a lower aggregation of genetic mutations compared to dysplastic lesions (de Sousa et al, 2009b). On the other hand, there was no significant difference between OLP and epithelial dysplasia indicating an equal potential for these two groups to develop malignancy.…”

Section: Discussioncontrasting

confidence: 58%

“…In another study by de Sousa et al (2009b), evaluation of cell proliferation in OSCC, dysplastic and OLP cases showed significant difference between OLP and OSCC . However, there was no significant difference between OLP and epithelial dysplasia (de Sousa et al, 2009b), which was similar to those of the present study regardless of the evaluation methods and cell proliferation markers applied.…”

Section: Discussionmentioning

confidence: 91%

“…An increase in cell proliferation might result in a suitable ground for malignant transformation (de Sousa et al, 2009b). A high rate of proliferation in OLP is potentially associated with a high risk for the presence of mutated cells during mitosis, which might result in a malignant phenotype in this lesion (González Moles et (20) al., 2009).…”

Section: Discussionmentioning

confidence: 99%

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Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Zargaran

Jamshidi²,

Eshghyar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Oral lichen planus (OLP) is categorized as premalignant lesion although its malignant potential is a matter of controversy. The objective of this study was to investigate Ki67 expression in OLP, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Materials and Methods: Expression of Ki67 was evaluated through immunohistochemistry (IHC) in groups of A (17 cases of epithelial hyperplasia), B (16 cases of OLP), C1 (10 cases of mild epithelial dysplasia), C2 (10 cases of severe epithelial dysplasia), D1 (10 cases of well-differentiated OSCC), and D2 (10 cases of poorly-differentiated OSCC). Results: There was a significant difference in Ki67 expression based on quantitative analysis among the six studied groups as well as group B compared bilaterally with groups C2, D1 and D2 (p< 0.0001). However, there was no significant difference between groups B and C1 or between groups D1 and D2 (p> 0.05). Conclusions: Based on the results of the present study it may not be possible to definitely consider malignant transformation potential for OLP. However, expression of Ki67 was significantly higher in OLP than that of epithelial hyperplasia with no significant difference from that of mild epithelial dysplasia. This should be considered by clinicians to carefully and regularly follow up OLP lesions to detect potential subtle changes at an early stage.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Zargaran

Jamshidi²,

Eshghyar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Buajeeb et al (16) have reported that p16 is not reliable for oral mucosal dysplasia and malignant transformation, although it is possible that p16 plays a role in cell senescence in normal oral mucosa since the protein is detectable by Western blotting in normal oral mucosa (3). Sousa et al (17) have reported that no significant statistical difference of the cell proliferation rate between oral lichen planus and epithelial dysplasia (p>0.05) and between the epithelial dysplasia and oral squamous cell carcinoma (p>0.05) was observed.…”

Section: Discussionmentioning

confidence: 99%

An immunohistochemical study of the distribution of p 16 protein in oral mucosa in smokers, non-smokers and in frictional keratosis

Tarakji

Kujan²,

Nassani³

2010

Med Oral

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Objective: Our study aimed to characterize alteration in the immunohistochemical p16 expression in normal oral mucosa and non-neoplastic hyperproliferative disorders (i.e. frictional keratosis and mucosa from smokers). Study design: 43 specimen of oral mucosa were examined using immunohistochemistry. Results: In normal mucosa, there was strong positive nuclear staining in a proportion of fibroblasts and endothelial cells in the lamina propria, with variable expression in nuclei of the epithelial layer. However, when the patient's tobacco smoking was examined, p16 nuclear staining in oral epithelium was seen in 4/20 (20%) of smokers and 0/23 (0%) of non-smokers. In every case of frictional keratosis (n=11), there was strong nuclear staining of some basal and supra-basal cells. In addition, there was strong nuclear staining of parakeratinizing squamous in a band above the spinous layer. In clinically normal oral epithelium of smokers and in frictional keratosis, basal and supra-basal cells expressed strong p16 nuclear staining which was absent in the control tissue examined. Conclusion: Our data suggest that p16 expression may be involved in the long-term loss of proliferation in cell senescence of oral mucosa.

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“…Oral biopsy with a histopathological evaluation is necessary to validate the clinical diagnosis of LP. Most importantly, LP can develop into an oral squamous cell carcinoma [8,9]. There are several long-term prospective studies that show a malignant transformation rate of 4.0% [10,11].…”

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confidence: 99%

Malignant Transformation of Oral Lichen Planus in Labial Location in a 23-Year-Old Woman – Case Report

Zawadzka¹,

Pūrienė²,

Rimkevičius³

2015

Dent. Med. Probl.

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Lichen planus, a rare mucocutaneous disease affecting around 0.1-4.0% of the population [1], has been associated with a cell-mediated immunological dysfunction. It commonly affects middle-aged adults and it is more frequently observed in women than in men [2]. LP mainly affects oral mucosa, and skin involvement is rare [3]. Mucosal lesions are usually multiple and have a bilateral, symmetrical manifestation. Mucosal lesions frequently appear on the tongue, gingiva, and mucobuccal fold [4]. Nearly half of the patients, 47.6%, has multiple sites of involvement [5,6].A labial site and gum involvement are rare. The following clinical forms of LP have been identified: papular, reticular, ulcerative, plaque and atrophic [5,7]. Oral biopsy with a histopathological evaluation is necessary to validate the clinical diagnosis of LP. Most importantly, LP can develop into an oral squamous cell carcinoma [8,9]. There are several long-term prospective studies that show a malignant transformation rate of 4.0% [10,11].The present case report presents a case about a 23-year-old patient with an LP lesion that developed into a squamous cell carcinoma on a labial site. Different subject-related pathological, diagnostic and treatment aspects will be discussed. Case Report AbstractLichen planus (LP) having a potential for malignant transformation is a rare mucocutaneous disease most frequently observed in middle-aged women than in men. LP is uncommon in young patients and the involvement of a labial site and desquamative gingivitis are also rare. LP mainly affects oral mucosa, and skin involvement is rare. Mucosal lesions are usually multiple and have a bilateral, symmetrical manifestation. Mucosal lesions frequently appear on the tongue, gingiva, and mucobuccal fold. Nearly half of the patients has multiple sites of involvement. Oral biopsy with a histopathological evaluation is necessary to validate the clinical diagnosis of LP. Malignant transformation is uncommon for young patients with a short history of LP and without the presence of other co-morbidities. The aim of the present report was to present a 23-year-old patient with an LP lesion which developed into a squamous cell carcinoma on a facial labial site. Different subject-related pathological, diagnostic and treatment aspects are discussed (Dent. Med. Probl. 2015, 52, 4, 512-515).

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Comparative Analysis of Cell Proliferation Ratio in Oral Lichen Planus, Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Cited by 25 publications

References 17 publications

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

An immunohistochemical study of the distribution of p 16 protein in oral mucosa in smokers, non-smokers and in frictional keratosis

Malignant Transformation of Oral Lichen Planus in Labial Location in a 23-Year-Old Woman – Case Report

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