Usefulness of Admission Red Cell Distribution Width as a Predictor of Early Mortality in Patients With Acute Pulmonary Embolism

Zorlu, Ali; Bektaşoğlu, Gökhan; Güven, Fatma Mutlu Kukul; Doǧan, Ömer Tamer; Gücük, Esra; Ege, Meltem Refıker; Altay, Hakan; Çınar, Ziynet; Tandoğan, İzzet; Yilmaz, Mehmet Birhan

doi:10.1016/j.amjcard.2011.08.015

Cited by 180 publications

(148 citation statements)

References 28 publications

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“…RDW levels that are higher than 14.8%, was associated with malignancy (p<0.001) (Beyazit et al, 2012). Early mortality rates in patients with acute dyspnea (Hong et al, 2012) and acute pulmonary embolism (Zorlu et al, 2012) were also found associated with high levels of RDW. To obtain more compelling evidence and disclose the true value of RDW levels in specific conditions, more studies are needed with higher volume samples.…”

Section: Discussionmentioning

confidence: 88%

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Kayilioglu¹,

Dinç²,

Sozen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The Bethesda System for Reporting Thyroid Cytopathology is one of the main classification systems for thyroid nodules. It expects that 7% of all fine needle aspiration biopsies will be reported as atypia or follicular lesions of undetermined significance, and 5-15% of these undetermined nodules are malignant. Our study is a retrospective analysis of variables that may be associated with outcome in patients with indeterminate thyroid nodules. Materials and Methods: Patients who underwent thyroidectomy in our institution between 2010 and 2014 were retrieved from the institutional records database. Patient demographics and medical histories were recorded. All ultrasonography reports were examined for nodule features and biochemical blood levels, hormone levels and complete blood counts were recorded. Results: A total of 103 patient cytopathology reports were regarded as belonging to the undetermined category. Some 35% of patients had malignant nodules. Median preoperative red cell distribution width (RDW) level was 13.6 inthe benign group, while it was 14.3 in patients with malignancy, demonstrating a significant correlation (p=0.003). Only calcification presence was significantly different between benign and malignant groups on ultrasonography (p=0.034). Conclusions: Ultrasonography is one of the primary tools for this matter. RDW levels may become another promising tool to predict malignancy.

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Section: Discussionmentioning

confidence: 88%

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Kayilioglu¹,

Dinç²,

Sozen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…The RDW is a routinely and an easily measured parameter as a part of CBC and has recently been shown to be associated with cardiovascular disease, PE, pulmonary hypertension, and obstructive sleep apnea. 8,10,[28][29][30][31] It has been proposed that during HF, RDW levels have some features in common with a combination of chronic inflammation and oxidative stress. 32 Both RDW and CTEPH have some common features from the point of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Release of inflammatory cytokines that may affect bone marrow function and erythrocyte maturation, which is induced by erythropoietin, is inhibited therefore this process may lead increased RDW. 8,10,30 Chronic cardiopulmonary diseases have an association with nutritional deficiencies, comorbid diseases, and deterioration of renal function. As a result of these conditions, RDW may also increase.…”

Section: Discussionmentioning

confidence: 99%

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Red cell distribution width

et al. 2014

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The most important long-term complication of pulmonary thromboembolism is chronic thromboembolic pulmonary hypertension (CTEPH) that is associated with considerable morbidity and mortality. It is uncertain why some patients with acute pulmonary embolism (PE) develop CTEPH and others do not. Elevated red cell distribution width (RDW) has been associated with adverse outcomes of heart failure, PE, and idiopathic pulmonary hypertension. The aim of the present study was to investigate whether RDW might be a predictor of CTEPH in PE patients or not. This study is a retrospective cohort study. A total of 203 consecutive patients with acute PE were included. The RDW was higher in the CTEPH patients than the patients without CTEPH (17.04 + 3.46, 14.64 + 1.82, respectively, p ¼ 0.015). RDW was also higher in the CTEPH patients at the time of diagnosis of CTEPH during follow-up compared with the baseline RDW level at the time of PE diagnosis (18.63 + 3.58, 17.02 + 3.59, respectively, p ¼ 0.014). The optimal cutoff value of the RDW for predicting CTEPH was 14.65. The area under the curve of RDW for the prediction of CTEPH was 0.735 (95% confidence interval (CI): 0.600-0.869); in cases with RDW levels >14.65%, the specificity, sensitivity, and negative predictive value for CTEPH were 62% (95% CI: 0.55-0.69), 75% (95% CI: 0.47-0.92), and 96.7% (95% CI: 0.91-0.99), respectively. A multivariate regression analysis showed that RDW, hazard ratio: 1.58 (95% CI: 1.09-2.30), was a predictor of CTEPH (p ¼ 0.016). High level of RDW was an independent predictor of CTEPH in PE patients. Therefore, RDW levels may provide a prediction for CTEPH in PE patients.

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“…In studies performed by Rezende et al [24], Cay et al [25], and Ozsu et al [26], they found that high RDW level was associated with VTE and it was also an independent risk factor for mortality and VTE diagnosis. Zorlu et al [27] found that RDW seems to aid in the risk stratification of patients with acute PE with RDW [14.6. These studies found that a high RDW level was an independent predictor for early PE-related mortality and other DVT associated risk factors but cannot exclude the possibility that anisocytosis was the result of thrombotic event itself.…”

Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width Has a Predictable Value for Differentiation of Provoked and Unprovoked Venous Thromboembolism

Ertop

Bilici

Engın

et al. 2015

Indian J Hematol Blood Transfus

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Venous thromboembolism (VTE) is generally classified as provoked or unprovoked. This dichotomy is important for following patients, mortality rate, prognosis and whether more efficient therapy is needed. In VTE patients, during initial diagnosis, it is not known exactly whether red cell distribution width (RDW) have a predictable value for this differentiation and pathogenesis. In this study, 298 patients with VTE and 197 control subjects were included. Patients with VTE were defined as provoked or unprovoked with respect to physical examination findings and laboratory values. Changes in RDW were tested between VTE patients and control subjects, provoked and unprovoked VTE patients, and separately with control subjects. RDW was found to be high in provoked and unprovoked groups compared with control group (p \ 0.001, p = 0.003 respectively). RDW was significantly high in provoked VTE patients group compared with unprovoked patients (p \ 0.001) and a cut-off value was found to be 13.6 %. In ROC analysis, sensitivity was 90.19 % and specificity was 82 % (95 % CI 85. . RDW could be used as a simple, costeffective and a reliable test independent of age in differentiation of provoked and unprovoked VTE. In order to better understand its role, prospective large homogenized population studies in different regions are necessary.

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Usefulness of Admission Red Cell Distribution Width as a Predictor of Early Mortality in Patients With Acute Pulmonary Embolism

Cited by 180 publications

References 28 publications

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Red cell distribution width

Red Cell Distribution Width Has a Predictable Value for Differentiation of Provoked and Unprovoked Venous Thromboembolism

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