Red Cell Distribution Width Has a Predictable Value for Differentiation of Provoked and Unprovoked Venous Thromboembolism

Abstract

Venous thromboembolism (VTE) is generally classified as provoked or unprovoked. This dichotomy is important for following patients, mortality rate, prognosis and whether more efficient therapy is needed. In VTE patients, during initial diagnosis, it is not known exactly whether red cell distribution width (RDW) have a predictable value for this differentiation and pathogenesis. In this study, 298 patients with VTE and 197 control subjects were included. Patients with VTE were defined as provoked or unprovoked with respect to physical examination findings and laboratory values. Changes in RDW were tested between VTE patients and control subjects, provoked and unprovoked VTE patients, and separately with control subjects. RDW was found to be high in provoked and unprovoked groups compared with control group (p \ 0.001, p = 0.003 respectively). RDW was significantly high in provoked VTE patients group compared with unprovoked patients (p \ 0.001) and a cut-off value was found to be 13.6 %. In ROC analysis, sensitivity was 90.19 % and specificity was 82 % (95 % CI 85. . RDW could be used as a simple, costeffective and a reliable test independent of age in differentiation of provoked and unprovoked VTE. In order to better understand its role, prospective large homogenized population studies in different regions are necessary.

Serial values of hematologic variables and deep venous thrombosis: Red cell distribution width is associated with deep venous thrombosis

“…found a significantly higher RDW in provoked VTE, compared to unprovoked VTE ( p < 0.001), and showed that high RDW levels were related to both provoked and unprovoked VTE, but more significant in provoked VTE. 18 Several studies showed that increased RDW levels were seen in cardiovascular disease and heart failure, stroke, chronic renal insufficiency, systemic inflammation, chronic obstructive pulmonary disease, malignancies, peripheral artery disease, pulmonary arterial hypertension and with diabetes-associated complications. 18 , 19 The vast majority of these risk factors have been associated with provoked VTE.…”

“… 18 Several studies showed that increased RDW levels were seen in cardiovascular disease and heart failure, stroke, chronic renal insufficiency, systemic inflammation, chronic obstructive pulmonary disease, malignancies, peripheral artery disease, pulmonary arterial hypertension and with diabetes-associated complications. 18 , 19 The vast majority of these risk factors have been associated with provoked VTE. The patients who have these diseases, in addition to the effect of VTE itself, have some risk factors that also lead to an elevated RDW.…”

Association Between Red Blood Cell Indices and Preoperative Deep Vein Thrombosis in Patients Undergoing Total Joint Arthroplasty: A Retrospective Study

“…The red blood cell distribution width (RDW) is a measurement of the size of RBC, thus “width” refers to the width of the distribution curve rather than the width of cells, and it is also an index of heterogeneity of RBC. 12 RDW and RBCs affect the well-known Virchow's triad of blood stasis, endothelial injury, and hypercoagulability, making them important factors in pro-thrombotic states such as PE and DVT. 13 Xiong et al found that the decreased RBC count was a risk factor for preoperative DVT before TKA.…”