Usefulness of admission hematologic parameters as diagnostic tools in acute pulmonary embolism

Abstract

The purpose of this study was to determine the role of red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in the diagnostic phase of acute pulmonary embolism (PE). We screened 248 consecutive patients who were admitted to the emergency service with PE foremost in the differential diagnosis. Based on spiral computed chest tomography, the patients were divided into two groups. There were 112 confirmed cases of acute PE and 138 patients without PE. Blood samples were obtained within 2 hours of presentation and before starting any medication. There were no significant differences between the PE and the non-PE groups with respect to sex, age, frequency of disease, serum creatinine, sodium, and potassium (p > 0.05 for all). NLR, RDW, and PLR were higher in patients with PE than those without PE. High-sensitivity C-reactive protein, D-dimer, and troponin levels were also higher in patients with PE. RDW values were positively correlated with troponin levels (r = 0.147, p = 0.021). There were no correlations between RDW and NLR, PLR, or D-dimer. NLR had a highly positive correlation with PLR (r = 0.488, p < 0.001). In multivariate logistic regression analysis, troponin I, D-dimer, high-sensitivity C-reactive protein, and RDW were found to be independent predictors of PE [odds ratio (95% confidence interval) respectively: 5.208 (2.534-10.704), 1.242 (1.094-1.409), 1.005 (1.000-1.010), 1.175 (1.052-1.312)]. In receiver operating characteristic analysis of the patients in the study, RDW >18.9 predicted acute PE with a sensitivity of 20.7% and a specificity of 93.4%. In conclusion, RDW can be considered useful as a diagnostic measure for patients with suspected acute PE.

Relationship between the red blood cell distribution width (RDW) and erythrocyte values in anemic and non-anemic cats

“…Mean corpuscular values determined in this experiment as well as other parameters of normal erythrograms were within the normal range for adult cats, thereby corroborating the findings of Clinkenbeard and Meinkoth (2000). In our study, no statistical differences were verified between males and females when associating sex with RDW.…”

“…(RIOND et al, 2011). In humans, recent studies have shown that increased RDW can be considered as a risk factor for diseases such as cardiovascular diseases (TSELIOU et al, 2014), breast cancer (SERETIS et al, 2013), and pulmonary diseases (CELIK et al, 2015).…”

Assessment of the haematological indices of albino rats fed diets supplemented with jackfruit bulb, seed or a blend of bulb and seed

“…Haematological indices such as the number and morphology of erythrocytes, leucocytes, and thrombocytes are useful in disease diagnosis and monitoring (Oyewole et al, 2009;Owoeye et al, 2011;Celik et al, 2015). According to Etim et al (2014), the examination of blood provides the opportunity to clinically investigate the nutritional, physiological and pathological status of an individual or an animal.…”

Association between elevated red blood cell distribution width and long-term mortality in acute pulmonary embolism

“…Acute pulmonary embolism (PE) is a common lifethreatening cardiovascular disease with 15%-20% mortality (1). Complete blood count is a part of routine laboratory tests performed for patients admitted to the emergency department, and red cell distribution width (RDW), as a marker of anisocytosis, reflects the heterogeneity of red blood cell (RBC) size.…”