Usefulness of Adiponectin as a Predictor of All Cause Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Lindberg, Søren; Pedersen, Sune; Møgelvang, Rasmus; Bjerre, Mette; Frystyk, Jan; Flyvbjerg, Allan; Galatius, Søren; Jensen, Jan Skov

doi:10.1016/j.amjcard.2011.09.041

Cited by 59 publications

(61 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, adiponectin significantly maintained its association with mortality, whatever the severity of the disease at variance by Beatty et al 25 and Cavusoglu et al 22 Other studies have also demonstrated this relationship in patients with unstable CAD or acute coronary syndrome. 22,26,44 Overall, our study provides new evidence that in stable CAD patients, high adiponectin level is associated with an increased risk of all-cause mortality and CVD mortality, whatever the severity of the disease.…”

Section: Discussionmentioning

confidence: 89%

“…18 Results were more homogeneous when the relationship between adiponectin and mortality risk was investigated. Paradoxically, a high serum adiponectin level was associated with an increased mortality risk from all causes and from CVD in healthy people, [19][20][21] as well as in patients with CAD, [22][23][24][25][26] heart failure, 21,27,28 renal insufficiency, 29 or type 1 diabetes mellitus. 30 The underlying mechanisms of the association among adiponectin, cardiovascular risk, and mortality still remain to be elucidated.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Adiponectin and Long-Term Mortality in Coronary Artery Disease Participants and Controls

Hascoët

Elbaz

Bongard

et al. 2013

ATVB

View full text Add to dashboard Cite

Objective— Despite cardioprotective properties, studies investigating adiponectin as a cardiovascular disease marker led to conflicting results. We investigated in participants with stable coronary artery disease (CAD) and controls whether serum adiponectin was associated with long-term mortality, considering varying degrees of CAD severity. Methods and Results— A case–control design with prospective median follow-up of 8.1 years was used. Survival rates among 715 CAD men (aged 45–74 years) in increasing quartiles of serum adiponectin values were 87.5%, 85.6%, 76.4%, and 67.6%, respectively ( P <0.001). Survival rates in 782 controls with adiponectin <9.1 µg/mL and ≥9.1 µg/mL (third quartile) were 95.3% and 91.0%, respectively ( P =0.035). Adiponectin concentration above the highest quartile was associated with an increased risk of total and cardiovascular disease mortality in CAD patients ( P =0.001 and P =0.001) and controls ( P =0.02 and P =0.004). The associations among high adiponectin, total mortality, and cardiovascular disease mortality remained significant after multivariate adjustments for metabolic, cardiac, and CAD severity variables. No significant interaction was found among CAD patients, controls, and the relationship of adiponectin with mortality. Conclusion— High serum adiponectin is a predictor of mortality, particularly from cardiovascular disease. This prognostic value remains significant whatever the severity of the CAD and the metabolic status and is not different among people with and without CAD.

show abstract

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

Adiponectin and Long-Term Mortality in Coronary Artery Disease Participants and Controls

Hascoët

Elbaz

Bongard

et al. 2013

ATVB

View full text Add to dashboard Cite

show abstract

“…Seven hundred and thirty-five consecutive patients with STEMI treated with primary percutaneous coronary intervention were included in a report by Lindberg et al [88] . Plasma adiponectin was measured immediately before the procedure.…”

Section: Adiponectinmentioning

confidence: 99%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

View full text Add to dashboard Cite

Obesity has become an important public health issue in Western and developing countries, with well known metabolic and cardiovascular complications. In the last decades, evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences. As a consequence of the expansion of fat depots, in obese subjects, adipose tissue cells develope a phenotypic modification, which turns into a change of the secretory output. Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling, vascular biology and, moreover, participate to the systemic inflammatory response, which characterizes obesity and metabolic syndrome. This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events. A great number of adipocytokines have been described recently, linking inflammatory mileu and vascular pathology. The understanding of these pathways is crucial not only from a pathophysiological point of view, but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets. The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. Key words: Adipocytokines; Obesity; Metabolic syndrome; Coronary artery disease; Inflammation Core tip: Our article, provide a comprehensive review of the evidence about adipose tissue and cardiovascular risk, focusing on the pathophysiological and clinical role of fat-derived mediators, the so-called adipocytokines.

show abstract

“…18 Lindberg et al reported that high adiponectin levels increased the mortality rate in patients with AMI, and suggested that increased adiponectin may reflect the process of stabilizing the ruptured plaque. 29 Therefore, our result suggests that increased adverse events in patients with high adiponectin levels were associated with severe myocardial damage and left ventricular (LV) dysfunction.…”

Section: Multivariate Analysis Of Adipokinesmentioning

confidence: 92%

“…4 However, after the onset of AMI, the effect of adiponectin on prognosis appear to change paradoxically. 28, 29 Some groups reported that high serum adiponectin levels were associated with a poor prognosis in patients with heart failure. 9,10,30 in the present study we also demonstrated that subjects with high adiponectin levels had a higher incidence of the primary endpoint after AMI.…”

Section: Multivariate Analysis Of Adipokinesmentioning

confidence: 99%

Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction

Morita

Maeda

Kondo

et al. 2013

Circ J

View full text Add to dashboard Cite

Usefulness of Adiponectin as a Predictor of All Cause Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Cited by 59 publications

References 28 publications

Adiponectin and Long-Term Mortality in Coronary Artery Disease Participants and Controls

Adiponectin and Long-Term Mortality in Coronary Artery Disease Participants and Controls

Adipose tissue and vascular inflammation in coronary artery disease

Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction

Contact Info

Product

Resources

About