Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction

Morita, Yasuhiro; Maeda, Kengo; Kondo, Takahisa; Ishii, Hideki; Matsudaira, Kyoko; Okumura, Naoki; Mitsuhashi, Hirotsugu; Shibata, Rei; Murohara, Toyoaki

doi:10.1253/circj.cj-13-0251

Cited by 22 publications

(12 citation statements)

References 42 publications

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“…Higher adiponectin and lower leptin levels were found to be associated with a high incidence of adverse events also in a Japanese cohort after successful emergency percutaneous coronary intervetion for AMI [69] . A low leptin to adiponectin ratio remained a significant independent predictor of adverse events during long-term follow-up at the multivariable analysis.…”

Section: Leptinmentioning

confidence: 84%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

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Obesity has become an important public health issue in Western and developing countries, with well known metabolic and cardiovascular complications. In the last decades, evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences. As a consequence of the expansion of fat depots, in obese subjects, adipose tissue cells develope a phenotypic modification, which turns into a change of the secretory output. Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling, vascular biology and, moreover, participate to the systemic inflammatory response, which characterizes obesity and metabolic syndrome. This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events. A great number of adipocytokines have been described recently, linking inflammatory mileu and vascular pathology. The understanding of these pathways is crucial not only from a pathophysiological point of view, but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets. The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. Key words: Adipocytokines; Obesity; Metabolic syndrome; Coronary artery disease; Inflammation Core tip: Our article, provide a comprehensive review of the evidence about adipose tissue and cardiovascular risk, focusing on the pathophysiological and clinical role of fat-derived mediators, the so-called adipocytokines.

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Section: Leptinmentioning

confidence: 84%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

View full text Add to dashboard Cite

show abstract

“…In preclinical setting, both the leptin deficient and leptin receptor deficient mice exhibited a delayed resolution of arthritis [ 36 ], and leptin supplementation was reported to ameliorate arthritis [ 37 ]. Similar to RA, the importance of leptin has been demonstrated in cardiovascular disease [ 38 – 40 ], malnutrition, and sepsis [ 41 ], where low serum levels of leptin are unfavourable for survival. These observations indicate that leptin is not a simple reflection of inflammation being rather engaged in the network of molecular processes in RA pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis

Erlandsson

Medina

Silfverswärd

et al. 2016

Mediators of Inflammation

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Objectives. Smoking is pathogenic for rheumatoid arthritis (RA) being tightly connected to the genetic and serological risk factors for this disease. This study aims to understand connections between cigarette smoking and serum levels of IGF1 and adipokines in RA. Methods. Serum levels of IGF1 and adipokines leptin, adiponectin, resistin, and visfatin were measured in two independent cohorts of RA patients from Gothenburg (n = 350) and Leiden (n = 193). An association of these parameters with smoking was tested in a direct comparison and proved by bivariate correlation analysis. The obtained associations were further tested in multivariate regression models where the confounders (age, gender, disease duration, and BMI) were controlled. Results. The smokers had significantly lower serum levels of IGF1, adiponectin, and leptin compared to never smokers. In regression analysis, smoking and low leptin, but not adiponectin, were associated and predicted low IGF1. Additionally, high disease activity and high BMI increased the probability of low leptin. Conclusions. The study indicates cigarette smoking as an important cause of a relative IGF1 and leptin deficiency in RA patients. This novel association between smoking and hypoleptinemia may be of importance for long-term prognosis of RA and for prediction of comorbidities.

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“…In contrast with traditional risk factors for CAD, growing evidence has revealed that leptin resistance with hyperleptinemia, a phenomenon encountered in obesity and insulin resistance, plays an important role in the occurrence, severity, and extent of CV events. 10 , 15 , 26 , 27 Although the definitive role of leptin in the development of CVD remains to be clarified. One study noted lower serum leptin level that measured 7 days after acute MI onset is associated with a high incidence of adverse events in Japanese patients.…”

Section: Discussionmentioning

confidence: 99%

Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease

Chen¹,

Wang²,

Lee³

et al. 2018

TCRM

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PurposeHyperleptinemia has been independently associated with human cardiovascular (CV) diseases. Accordingly, we evaluate the association between serum leptin and future CV events in patients with coronary artery disease (CAD).Patients and methodsThis study enrolled 98 patients with CAD from January to December 2012. The primary endpoint included incidences of major adverse CV events and hospitalization. Patients follow-up had been completed on June 30, 2017.ResultsAfter a median follow-up of 52 months, 43 CV events had occurred. Patients with CV events had higher systolic blood pressure (P = 0.030), total cholesterol (P = 0.034), C-reactive protein (P = 0.018), and serum leptin levels (P = 0.001) than those without CV events. Kaplan–Meier analysis showed greater cumulative incidences of CV events in the high leptin group (median leptin concentration >6.03 ng/mL) than in the low leptin group (log-rank P = 0.012). Multivariate Cox regression analysis showed that triglyceride (HR: 1.010; 95% CI: 1.001–1.018; P = 0.022) and leptin levels (HR: 1.054; 95% CI: 1.026–1.082; P < 0.001) were independently associated with CV events in patients with CAD.ConclusionSerum leptin levels could serve as a biomarker for future CV events in patients with CAD.

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Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction

Cited by 22 publications

References 42 publications

Adipose tissue and vascular inflammation in coronary artery disease

Adipose tissue and vascular inflammation in coronary artery disease

Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis

Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease

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