Usefulness of a cube-copying test in outpatients with dementia

Maeshima, Shinichiro; Osawa, Aiko; Maeshima, Etsuko; Shimamoto, Yukiko; Sekiguchi, Eri; Kakishita, Koji; Ozaki, Fuminori; Moriwaki, Hiroshi

doi:10.1080/02699050410001671847

Cited by 31 publications

(34 citation statements)

References 9 publications

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“…Each plane with two pairs of parallel lines was evaluated in terms of the number of lines and the extent to which they were parallel. No plane-error points were scored if the cube was copied accurately [20]. We selected brief neuropsychological tests that could be performed within 1 h in order to reduce the burden on patients in the preoperative or postoperative therapeutic stage.…”

Section: Methodsmentioning

confidence: 99%

Cerebellar Contribution to Pattern Separation of Human Hippocampal Memory Circuits

et al. 2015

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The cerebellum is a crucial structure for cognitive function as well as motor control. Benign brain tumors such as schwannomas, meningiomas, and epidermoids tend to occur in the cerebellopontine angle cisterns and may cause compression of the posterior lateral cerebellum near the superior posterior fissure, where the eloquent area for cognitive function was recently identified. The present study examined cognitive impairment in patients with benign cerebellar tumors before and after surgical intervention in order to clarify the functional implications of this region in humans. Patients with cerebellar tumors showed deficits in psychomotor speed and working memory compared with healthy controls. Moreover, these impairments were more pronounced in patients with right cerebellar tumors. Functional magnetic resonance imaging during performance of a lure task also demonstrated that cerebellar tumors affected pattern separation or the ability to distinguish similar experiences of episodic memory or events with discrete, non-overlapping representations, which is one of the important cognitive functions related to the hippocampus. The present findings indicate that compression of the human posterior lateral cerebellum affects hippocampal memory function.

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Section: Methodsmentioning

confidence: 99%

Cerebellar Contribution to Pattern Separation of Human Hippocampal Memory Circuits

et al. 2015

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“…Furthermore, the applied 20-point scoring system of the cube copying test enables the detection of minor deficits of the visuospatial functions. Maeshima et al [9] have previously shown that this test can distinguish controls from AD subjects. However, to our knowledge, no previous study has investigated this assessment of the cube copying test in the prediction of AD in MCI subjects.…”

Section: Discussionmentioning

confidence: 99%

“…To evaluate the cube copying test in a quantitative manner, Maeshima et al [8] developed a rating scale of 20 points. Using this scale, patients with established AD could be separated from healthy controls [9] . However, such an extensive rating scale of the cube copying test has not been evaluated in the detection of preclinical AD.…”

Section: Introductionmentioning

confidence: 99%

Cube Copying Test in Combination with rCBF or CSF Aβ<sub>42</sub>Predicts Development of Alzheimer’s Disease

Buchhave

Stomrud

Warkentin

et al. 2008

Dement Geriatr Cogn Disord

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Background/Aim: The aim was to identify subjects with incipient Alzheimer’s disease (AD) among patients with mild cognitive impairment (MCI) using brief cognitive tests. Methods: A total of 147 MCI patients were followed for 4–6 years and the incidence of AD was 11.6%/year. At baseline, the cube copying test, clock drawing test, MMSE and measurements of regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) β-amyloid_1–42 (Aβ₄₂) were performed. Results: The cube copying test, but not the clock drawing test, could predict AD among MCI patients with an area under the receiver operating characteristic curve of 0.64 (p < 0.01). The relative risk for future AD was increased in MCI subjects with impaired cube copying test (sex- and age-adjusted hazard ratio = 1.8, p < 0.05) and the incidence of AD was 18.2% in this subgroup. Combining the cube copying test with either rCBF or CSF Aβ₄₂ had additive effects on the risk assessment for future development of AD. MCI patients achieving high scores on both MMSE and cube copying test had a very low risk of developing AD (incidence of AD = 1.6%). Conclusion: In conclusion, combinations of the cube copying test with MMSE, rCBF and CSF Aβ₄₂ measurements can identify subgroups of MCI subjects with either substantially reduced or increased risk for future development of AD.

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“…In addition, DLB patients as well as AD patients often show poor performances in cube or clock copying tests [17][18][19][20] , because of the difficulty for dementia patients to copy these designs. The Rey-Osterrieth complex figure test has not been examined in DLB patients but leads to poor performances in AD patients [21] .…”

Section: Introductionmentioning

confidence: 99%

Utility of the Bender Gestalt Test for Differentiation of Dementia with Lewy Bodies from Alzheimer’s Disease in Patients Showing Mild to Moderate Dementia

Murayama

Iseki

Yamamoto

et al. 2007

Dement Geriatr Cogn Disord

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Aims: We examined the utility of the Bender Gestalt Test (BGT) for the differentiation of dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD), comparing BGT scores between DLB and AD patients showing mild to moderate dementia. Methods: Eighteen DLB patients, 36 AD patients controlled by age, years of education, Clinical Dementia Rating and Mini Mental State Examination scores, and 21 nondemented elderly participants controlled by age and years of education were subjected to the BGT. Their BGT performances were scored according to the Pascal-Suttell method. Results: The DLB group showed significantly higher (that is worse) BGT scores than the other groups. When a cutoff point of 98 was used to differentiate DLB from AD, the patients exceeding 98 were 94% in the DLB group, 17% in the AD group and 0% in the control group. The sensitivity and specificity of this cutoff point were 0.94 and 0.89, respectively. Conclusion: The BGT is a useful neuropsychological test to differentiate DLB from AD.

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Usefulness of a cube-copying test in outpatients with dementia

Cited by 31 publications

References 9 publications

Cerebellar Contribution to Pattern Separation of Human Hippocampal Memory Circuits

Cerebellar Contribution to Pattern Separation of Human Hippocampal Memory Circuits

Cube Copying Test in Combination with rCBF or CSF Aβ<sub>42</sub>Predicts Development of Alzheimer’s Disease

Utility of the Bender Gestalt Test for Differentiation of Dementia with Lewy Bodies from Alzheimer’s Disease in Patients Showing Mild to Moderate Dementia

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