Abstract:BJP 137 1-8 Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx w w w . s b f g n o s i a . o r g . b r / r e v i s t a Original Article Useful Brazilian plants under the view of the writer-naturalist João a b s t r a c tThis study shows the results of a wide but non-exhaustive review on plants cited in the literacy work of the writer-naturalist João Guimarães Rosa (J.G. Rosa). Information about popular names and use of plants were recovered through a review in seven works of the author. The assignment of t… Show more
“…“Buriti,” Mauritia flexuosa L. f., belongs to the family Arecaceae, a palm tree widely distributed in South America, especially in the Amazon region and Brazilian Cerrado, where it has demonstrated high economic potential for the biotechnology development based on the sustainability of natural resources. In the Brazilian food industry, the peel and endocarp are commonly discarded or underutilized for the preparation of candies, ice creams, juices, jams, porridges, and/or oils [ 13 ]. Additionally, some studies have emphasized pharmacological potentialities of the M. flexuosa parts, such as antimicrobial [ 14 – 16 ], antitumor [ 16 ], hypolipemiant [ 17 ], hypoglycemiant [ 18 ], and healing activities [ 19 ].…”
Mauritia flexuosa (Arecaceae), known as “Buriti,” is a Brazilian palm tree with high economic potential for local communities. Herein, we investigated the phytochemistry profile and antioxidant potential of M. flexuosa fruits and determined the bioaccessibility of phenolic compounds. Peels revealed upper values for phenols, flavonoids, carotenoids, tannins, and ascorbic acid when compared to the pulps and endocarps. All samples showed capacity to scavenger free radicals (0.5, 1.0, 2.0, 4.0, and 8.0 mg/mL) but peels presented higher scavenger action in all methods explored. Phenolic compounds identified by HPLC displayed reduced bioaccessibility after in vitro simulated gastrointestinal digestion for pulp (38.7%), peel (18.7%), and endocarp (22.3%) extracts (P < 0.05). Buriti fruits also protected rat blood cells against lysis induced by peroxyl radicals. We demonstrated the promising chemopreventive potentialities of M. flexuosa fruits and their by-products and peels with higher quantities of bioactive compounds and phenolic substances before and after in vitro bioaccessibility investigation. In Brazil, these parts are discarded or underused, mainly as feed for ruminant animals. Consequently, it is extremely important to explore nutritional characteristics of these by-products for human/livestock foods and to install biofriendly techniques and sustainable biotechnology handling of natural resources.
“…“Buriti,” Mauritia flexuosa L. f., belongs to the family Arecaceae, a palm tree widely distributed in South America, especially in the Amazon region and Brazilian Cerrado, where it has demonstrated high economic potential for the biotechnology development based on the sustainability of natural resources. In the Brazilian food industry, the peel and endocarp are commonly discarded or underutilized for the preparation of candies, ice creams, juices, jams, porridges, and/or oils [ 13 ]. Additionally, some studies have emphasized pharmacological potentialities of the M. flexuosa parts, such as antimicrobial [ 14 – 16 ], antitumor [ 16 ], hypolipemiant [ 17 ], hypoglycemiant [ 18 ], and healing activities [ 19 ].…”
Mauritia flexuosa (Arecaceae), known as “Buriti,” is a Brazilian palm tree with high economic potential for local communities. Herein, we investigated the phytochemistry profile and antioxidant potential of M. flexuosa fruits and determined the bioaccessibility of phenolic compounds. Peels revealed upper values for phenols, flavonoids, carotenoids, tannins, and ascorbic acid when compared to the pulps and endocarps. All samples showed capacity to scavenger free radicals (0.5, 1.0, 2.0, 4.0, and 8.0 mg/mL) but peels presented higher scavenger action in all methods explored. Phenolic compounds identified by HPLC displayed reduced bioaccessibility after in vitro simulated gastrointestinal digestion for pulp (38.7%), peel (18.7%), and endocarp (22.3%) extracts (P < 0.05). Buriti fruits also protected rat blood cells against lysis induced by peroxyl radicals. We demonstrated the promising chemopreventive potentialities of M. flexuosa fruits and their by-products and peels with higher quantities of bioactive compounds and phenolic substances before and after in vitro bioaccessibility investigation. In Brazil, these parts are discarded or underused, mainly as feed for ruminant animals. Consequently, it is extremely important to explore nutritional characteristics of these by-products for human/livestock foods and to install biofriendly techniques and sustainable biotechnology handling of natural resources.
“…O buriti tem demonstrado elevado potencial nutricional e econômico com base no desenvolvimento de biotecnologia sustentável e utilização de recursos naturais, no entanto, na indústria alimentícia brasileira, a casca e o endocarpo são comumente descartados ou subutilizados, em detrimento da utilização da polpa no preparo de doces, sorvetes, sucos, compotas e mingaus, além da extração do óleo (CHAVES et al, 2015). Além disso, alguns estudos enfatizam as potencialidades farmacológicas…”
Section: Estudos Clínicos Desenvolvidos Pela European Association For Cardiovascularunclassified
“…Native of the Brazilian ‘cerrado’, occurring mainly in Minas Gerais, Goiás and Bahia States, species of the genus Lychnophora (Asteraceae) are popularly known as ‘arnica’. Aerial parts of these species macerated in alcoholic or hydroalcoholic preparations are used in folk medicine to treat pain, inflammation, rheumatism and bruises …”
Objectives
To perform the polymorphic and physicochemical characterization of the potential anti‐inflammatory drug, eremantholide C (EREC), as well as to evaluate the influence of these characteristics on its biopharmaceutics classification.
Methods
Eremantholide C was obtained from chloroformic extract of Lychnophora trichocarpha and crystallized in two distinct solvents: chloroform (EREC 1) and ethyl acetate (EREC 2). To evaluate the polymorphism, EREC samples were submitted to melting point, purity, infrared spectroscopy, differential scanning calorimetry (DSC), X‐ray powder diffraction, optical microscopy and scanning electron microscopy analysis. In addition, EREC samples crystallized after intrinsic dissolution study were submitted to DSC and X‐ray powder diffraction analysis.
Key findings
EREC 1 showed fusion at 234.7–241.6 °C, while EREC 2 showed fusion at 238.6–243.7 °C. No polymorphic transitions were observed during the intrinsic dissolution experiment. A single sharp endothermic peak was obtained for the EREC samples. X‐ray diffraction showed no crystallographic differences between the EREC samples. EREC 1 and EREC 2 showed birefringence under polarized light and indefinite morphology; however, the shape of the crystals was common to the two samples.
Conclusions
Eremantholide C does not present classical or morphological polymorphism; therefore, there is no influence of crystalline transitions in the solubility and consequently in its biopharmaceutics classification and oral absorption process.
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