Use the Chinese herbal compound regulatory network to verify the relationship between the Jun, Chen, Zuo, and Shi of Xiaochaihu Decoction in treating hepatitis

Ma, Yuexing; Meng, Xiaoqi; Pan, Rongbin; Zhu, Zhi‐Xin; Peng, Zirong; Liu, Simin; Zheng, H.F.; Hu, Huiming

doi:10.1016/j.prmcm.2021.100023

Cited by 6 publications

(1 citation statement)

References 40 publications

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“…The docking results showed that all biomarkers interacted with the target protein and had good affinities. Based on the theory of ‘ Jun‐chen‐zuo‐shi ’ [35], the biomarker M59 (catalpol) was derived from the ‘ jun ’ medicine of Shudihuang. The other three biomarkers were ‘Chen’ drugs based on Danggui, Chuanxiong, and Baishao: M32 (ligustilide), M23 (Paeoniflorin), and M13 (gallic acid).…”

Section: Resultsmentioning

confidence: 99%

Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng‐Nian‐Shu in perimenopausal syndrome

Zhang

et al. 2023

J of Separation Science

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Although Geng-Nian-Shu has been shown to be clinically effective in perimenopausal syndrome, its active components and mechanism have not yet been elucidated. To demonstrate the mechanism-based biomarkers of Geng-Nian-Shu in treating perimenopausal syndrome, a total of 135 chemical constituents including 52 prototype blood constituents were identified via high-performance liquid chromatography-quadrupole-time of flight/mass spectrometry. Then, network pharmacology showed significant enrichment for the PhosphoInositide-3 Kinase/Akt pathway, suggesting that it may be the main regulatory pathway for the Geng-Nian-Shu treatment of the perimenopausal syndrome. Subsequently, multivariate analysis was performed between the Geng-Nian-Shu sham-treated and Geng-Nian-Shu ovariectomy-treated groups and further screened out 18 prototype blood constituents by correlation analysis with plasma estrogen levels to identify potential biomarkers associated with Geng-Nian-Shu treat the ovariectomy-induced perimenopausal syndrome. Finally, the results of pharmacological experimental verification and Pearson correlation analysis indicated that catalpol, ligustilide, paeoniflorin, and gallic acid were selected as biomarkers of Geng-Nian-Shu which were strongly and positively correlated with PhosphoInositide-3 Kinase/Akt signaling pathway. In this study, based on highperformance liquid chromatography-quadrupole-time of flight/mass spectrometry combined with pharmacodynamics, network pharmacology, pharmacology, and other disciplines, we explored the effects and mechanisms of Geng-Nian-Shu in the treatment of perimenopausal syndrome at multiple levels. Using multiplatform technology to investigate the role of Geng-Nian-Shu represents a new strategy for the selection and verification of biomarkers of Geng-Nian-Shu and provides a basis for further development and utilization of Geng-Nian-Shu.

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Section: Resultsmentioning

confidence: 99%

Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng‐Nian‐Shu in perimenopausal syndrome

Zhang

et al. 2023

J of Separation Science

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Topical and transdermal botanical formulations of the Chinese pharmacopoeia—A review

Gu,

Lane,

Da Silva Sil Dos Santos

et al. 2024

Phytotherapy Research

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In pharmaceutics, ingredients are classified as active ingredients and excipients. In topical/transdermal phytomedicines, an ingredient may serve both functions. Published information on these dual‐purpose ingredients and their pharmacological relevance is limited. An intriguing scenario arises in traditional Chinese medicine (TCM) formulations, where active ingredients and excipients are undifferentiated. This study analyzes ingredients in TCM topical/transdermal formulations, aiming at harmonization of understanding of TCMs. The most commonly recorded ingredients from such formulations in the Chinese pharmacopoeia 2020 (ChP 2020) are reviewed, aiming at developing innovative topical/transdermal phytomedicines. Current editions of Chinese historical documents were reviewed to explore the principles underlying the use of these ingredients. TCM formulations containing botanical drugs for topical/transdermal application were selected from the ChP 2020. The use of botanical materials in TCM formulations is guided by the “Jun‐Chen‐Zuo‐Shi” principle rooted in Yin‐Yang and the five elements' theories. In the ChP 2020, 155 botanical drugs, along with 40 excipients (from the “procedure” section, focusing on processing and technical parameters), were identified from 34 botanical formulations intended for topical/transdermal application. Pungent and aromatic botanical materials were the most frequently recorded. Adhesive plasters were the most commonly recorded TCM dosage form, employing specific matrix blends. This new perspective of study reveals the prevalence of pungent and aromatic botanical materials, the common use of adhesive plasters, multifunctional properties of botanical oils, and formulation adaptability in TCM topical/transdermal products. These insights should inform novel formulation designs for both pharmaceutical and phytopharmacological research.

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Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

Tang

Shen

Wang

et al. 2023

Biomedicine & Pharmacotherapy

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Use the Chinese herbal compound regulatory network to verify the relationship between the Jun, Chen, Zuo, and Shi of Xiaochaihu Decoction in treating hepatitis

Cited by 6 publications

References 40 publications

Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng‐Nian‐Shu in perimenopausal syndrome

Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng‐Nian‐Shu in perimenopausal syndrome

Topical and transdermal botanical formulations of the Chinese pharmacopoeia—A review

Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

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