Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

Tang, Peng; Shen, Tian-Ze; Wang, Hairong; Zhang, Ruihan; Zhang, Xing-Jie; Li, Xiao-Li; Xiao, Wei‐Lie

doi:10.1016/j.biopha.2023.114955

Cited by 8 publications

(3 citation statements)

References 287 publications

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“…[2] In addition, due to their high volatility and hydrophobic nature, the functionality of other compounds mainly essential oils and Vitamins is lost that pose a challenge to incorporate them into aqueous systems. [9,10] Moreover, degradative enzymes, oxygen, temperature, light, moisture content, water activity, pH, and other factors can all contribute to the breakdown of biocomponents during the manufacturing, drug delivery, and storage phases. [11] Indeed, the scientific community highlighted that some changes must be made in drug design and development in order to enhance the targeting feature, stability, and solubility of valuable compounds.…”

Section: Introductionmentioning

confidence: 99%

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

Aanniz,

El Omari,

Elouafy

et al. 2024

Chemistry & Biodiversity

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Encapsulation has emerged as a vitally important tool for protecting the integrity of critical chemicals and improving the delivery mechanisms of natural/synthetic drugs, enabling the controlled release of ingredients and the maintenance of their chemical, physical, and biological properties. It is well known that essential oils (EOs) provide a valuable alternative for food preservation, as they help reducing the deterioration of foodstuffs as well as the proliferation of pathogens. Nevertheless, EOs are highly volatile and lipophilic, rendering them insoluble in aqueous systems. In addition, their secondary metabolites are extremely susceptible to environmental factors such as humidity, temperature, light, and oxygen. Therefore, encapsulation of EOs is an innovative option not only for preserving these substances but also for promoting their stability, controlling their release, and optimizing their efficiency and bioavailability. In this sense, this review aimed to describe current techniques and approaches used to incorporate natural hydrophobic compounds, covering EOs. It also examines whether encapsulation technology can be used efficiently in drug discovery and development. Studies have shown that microencapsulation, the use of nanoparticle, and liposomal are the most effective techniques for encapsulating EOs. Other encapsulation systems included spray drying, coacervation, and emulsification.

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Section: Introductionmentioning

confidence: 99%

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

Aanniz,

El Omari,

Elouafy

et al. 2024

Chemistry & Biodiversity

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“…Medicinal plants refer to plants used in medicine to prevent and treat diseases [ 1 ]. All or part of medicinal plants are used in medicine and will also be used as raw materials for the pharmaceutical industry, which have a wide range of medicinal and economic uses [ 2 ]. Especially in the field of traditional medicine represented by traditional Chinese medicine and Indian folk medicine, medicinal plants, as the main source of natural drugs, provide very important health care services for the population of developing countries [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Especially in the field of traditional medicine represented by traditional Chinese medicine and Indian folk medicine, medicinal plants, as the main source of natural drugs, provide very important health care services for the population of developing countries [ 3 , 4 , 5 ]. With the rapid development of modern medicine, many clinical drugs still come from natural products extracted from medicinal plants [ 2 ]. Although many kinds of medicinal plants have been used in clinical treatment, due to environmental stress, overexploitation, low reproductive capacity, and other factors, some rare, high-demand, and wild medicinal plant resources cannot meet the market demand, so how to improve the germplasm resources of medicinal plants has become an urgent problem to be solved.…”

Section: Introductionmentioning

confidence: 99%

Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts

Wang

Zhang

Hao

et al. 2023

Life

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With the increasing demand for medicinal plants and the increasing shortage of resources, improving the quality and yield of medicinal plants and making more effective use of medicinal plants has become an urgent problem to be solved. During the growth of medicinal plants, various adversities can lead to nutrient loss and yield decline. Using traditional chemical pesticides to control the stress resistance of plants will cause serious pollution to the environment and even endanger human health. Therefore, it is necessary to find suitable pesticide substitutes from natural ingredients. As an important part of the microecology of medicinal plants, endophytes can promote the growth of medicinal plants, improve the stress tolerance of hosts, and promote the accumulation of active components of hosts. Endophytes have a more positive and direct impact on the host and can metabolize rich medicinal ingredients, so researchers pay attention to them. This paper reviews the research in the past five years, aiming to provide ideas for improving the quality of medicinal plants, developing more microbial resources, exploring more medicinal natural products, and providing help for the development of research on medicinal plants and endophytes.

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Luteolin: A promising multifunctional natural flavonoid for human diseases

Zhu,

Sun,

et al. 2024

Phytotherapy Research

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Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It is noteworthy that LUT exhibits a variety of beneficial pharmacological properties and holds significant potential for clinical applications, particularly in antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, and other aspects. The potential mechanism of action has been partially elucidated, including the mediation of NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, and Nrf‐2, among others. The review that aimed to comprehensively consolidate essential information on natural sources, pharmacological effects, therapeutic and preventive potential, as well as potential mechanisms of LUT. The objective is to establish a theoretical basis for the continued development and application of LUT.

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Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

Cited by 8 publications

References 287 publications

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications

Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts

Luteolin: A promising multifunctional natural flavonoid for human diseases

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