Use patterns, excretion masses and contamination profiles of antibiotics in a typical swine farm, south China

Zhou, Lijun; Ying, Guang‐Guo; Zhang, Ruiquan; Liu, Shan; Lai, Hua‐Jie; Chen, Zhi Feng; Yang, Bin; Zhao, Jian‐Liang

doi:10.1039/c3em30682h

Cited by 44 publications

(24 citation statements)

References 55 publications

(53 reference statements)

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“…In some situations there is a risk of animals developing a resistance to antibiotics such as tetracyclines, sulfonamides, fluroquinalones and zinc bacitracin that are routinely used in feed formulations [25]. A recent study based on data collected from pig herds in Southern China reported that antibiotic excretion rates for sows was 48 mg/day, weaning piglets 19 mg/day, growing pigs 7 mg/day and finishing pigs 1.5 mg/day [26] indicating that the usage of antibiotics and therefore excretion masses are correlated with stock class. High L. intracellularis seropositivity is known to be associated with withdrawal of in-feed medication in fattening pig diets.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China

Ling

Tian

et al. 2014

BMC Vet Res

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BackgroundPorcine proliferative enteropathy caused by Lawsonia intracellularis (L. intracellularis) is a major concern to the pig industry worldwide. Although 8.3 billion pigs are produced each year in China, few reports on the prevalence of L.intracellularis infection are available. The aim of the current study was to estimate the seroprevalence of L. intracellularis antibodies in intensive pig farms in China.ResultsA total of 1060 serum samples were collected from 14 commercial pig farms located throughout China. Animals from all age groups were sampled including pre-weaning piglets, weaners, fattening pigs, adult sows and boars. Antibodies against L. intracellularis were detected using a specific blocking ELISA. Of the 1060 serum samples, 602 were identified as positive using the ELISA test. The apparent seroprevalence of L. intracellularis seropositivity was 57% (95% CI 50 to 64%). The true prevalence (that is, prevalence corrected for the imperfect sensitivity and specificity of the testing method) was 77% (95% CI 70 to 83%).ConclusionsThe highest true prevalence was observed in sows and boars, suggesting that within a herd these stock classes are a reservoir for infection. The prevalence of L. intracellularis seropositivity in local breed pigs was significantly less than that in imported breeds. A higher seroprevalence was found in pigs in herds in Central and Northern China, which may correspond to the greater use of the intensive production systems in these areas. We conclude that L. intracellularis is widely prevalent in commercial pigs in China.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China

Ling

Tian

et al. 2014

BMC Vet Res

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“…Multiple classes of antibiotics have been recovered in the manure of swine, chicken and cattle Hu et al 2008b;Li et al 2013c;Zhou et al 2013c). Fluoroquinolones (FQ), sulfonamides (SA) and tetracyclines (TC) were the most frequently detected antibiotics and exhibited a broad concentration range ( Figure S4).…”

Section: Antibiotics In Livestock Farm Wastesmentioning

confidence: 99%

Review of antibiotic resistance in China and its environment

Qiao

Ying

Singer

et al. 2018

Environment International

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390

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Antibiotic resistance is a global health crisis linked to increased, and often unrestricted, antibiotic use in humans and animals. As one of the world's largest producers and consumers of antibiotics, China is witness to some of the most acute symptoms of this crisis. Antibiotics and antibiotic resistance genes (ARGs) are widely distributed in surface water, sewage treatment plant effluent, soils and animal wastes. The emergence and increased prevalence of ARGs in the clinic/hospitals, especially carbapenem-resistant gram negative bacteria, has raised the concern of public health officials. It is important to understand the current state of antibiotic use in China and its relationship to ARG prevalence and diversity in the environment. Here we review these relationships and their relevance to antimicrobial resistance (AMR) trends witnessed in the clinical setting. This review highlights the issues of enrichment and dissemination of ARGs in the environment, and also future needs in mitigating the spread of antibiotic resistance in the environment, particularly under the 'planetary health' perspective, i.e., the systems that sustain or threaten human health.

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“…In addition to these six ARG types, aminoglycoside resistance genes also decreased from their high background abundance ratio of 1.4 × 10 − 1 -6.0 × 10 − 2 . This might be due to the practice of feeding more antibiotics to young pigs more susceptible to disease, and reducing or eliminating such feed amendments to older pigs (Zhou et al, 2013;Jensen and Hayes, 2014). …”

Section: Widespread Occurrence Of Vancomycin Resistance Genesmentioning

confidence: 99%

Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes

et al. 2015

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A metagenomic approach and network analysis was used to investigate the wide-spectrum profiles of antibiotic resistance genes (ARGs) and their co-occurrence patterns in 50 samples from 10 typical environments. In total, 260 ARG subtypes belonging to 18 ARG types were detected with an abundance range of 5.4 × 10 − 6 -2.2 × 10 −1 copy of ARG per copy of 16S-rRNA gene. The trend of the total ARG abundances in environments matched well with the levels of anthropogenic impacts on these environments. From the less impacted environments to the seriously impacted environments, the total ARG abundances increased up to three orders of magnitude, that is, from 3.2 × 10 − 3 to 3.1 × 10 0 copy of ARG per copy of 16S-rRNA gene. The abundant ARGs were associated with aminoglycoside, bacitracin, β-lactam, chloramphenicol, macrolide-lincosamide-streptogramin, quinolone, sulphonamide and tetracycline, in agreement with the antibiotics extensively used in human medicine or veterinary medicine/promoters. The widespread occurrences and abundance variation trend of vancomycin resistance genes in different environments might imply the spread of vancomycin resistance genes because of the selective pressure resulting from vancomycin use. The simultaneous enrichment of 12 ARG types in adult chicken faeces suggests the coselection of multiple ARGs in this production system. Non-metric multidimensional scaling analysis revealed that samples belonging to the same environment generally possessed similar ARG compositions. Based on the co-occurrence pattern revealed by network analysis, tetM and aminoglycoside resistance protein, the hubs of the ARG network, are proposed to be indicators to quantitatively estimate the abundance of 23 other co-occurring ARG subtypes by power functions.

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Use patterns, excretion masses and contamination profiles of antibiotics in a typical swine farm, south China

Cited by 44 publications

References 55 publications

Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China

Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China

Review of antibiotic resistance in China and its environment

Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes

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