Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan

Chu, Shih-Meng; Shih, Wei-Tai; Chu, Yen-Hua

doi:10.1016/j.jep.2015.03.047

Cited by 47 publications

(35 citation statements)

References 37 publications

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“…An inverse relationship between regular seaweed consumption and reduced risk of hypertension and cardiovascular disease was observed in epidemiological studies (Nanri et al 2017;Maruyama et al 2013;Chu et al 2015;review by Cornish et al 2015). Japan and South Korea have two of the longest average life spans and take less medication for hypertension and cardiovascular disease than populations with lower seaweed intakes (Lee et al 2016;Yamori et al 2017).…”

Section: Hypertension and Cardiac Diseasementioning

confidence: 88%

Seaweeds as nutraceuticals for health and nutrition

2019

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Throughout human history, seaweeds have been used as food, folk remedies, dyes, and mineral-rich fertilisers. Seaweeds as nutraceuticals or functional foods with dietary benefits beyond their fundamental macronutrient content, are now a major research and industrial development concept. The occurrence of dietary and lifestyle-related diseases, notably type 2 diabetes, obesity, cancer, and metabolic syndrome has become a health epidemic in developed countries. Global epidemiological studies have shown that countries where seaweed is consumed on a regular basis have significantly fewer instances of obesity and dietary-related disease. This review outlines recent developments in seaweed applications for human health from an epidemiological perspective and as a functional food ingredient.

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Section: Hypertension and Cardiac Diseasementioning

confidence: 88%

Seaweeds as nutraceuticals for health and nutrition

2019

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“…23,24 Therefore, the combination of TJ and statins has emerged in recent years for hyperlipidemia treatment in China. 25 Several studies investigated this combination in animal models. 26 Although the combination of drugs may be beneficial and reduce side effects, the risk of adverse drug interactions may increase.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Drug Interaction Between Rosuvastatin and Tanjin in Healthy Volunteers and Rats

et al. 2019

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Background Tanjin is an herbal medicine made from the root of salvia miltiorrhiza. It is predominantly given to arteriosclerotic patients as a supplement to ameliorate the clinical symptoms of cardiovascular diseases. In China, tanjin is used frequently in combination treatment for hypercholesterolemia. Thus, there is a high probability of combination of tanjin and statins in these arteriosclerotic patients. This study investigated the interaction between tanjin and rosuvastatin. Methods We performed a randomized single-blind, two-period crossover clinical trial on six healthy male volunteers. Volunteers were administered rosuvastatin with placebo or a tanjin-containing drug randomly. The blood samples were collected before drug administration, and at 0.5, 1, 1.5, 2, 4, 8, and 12 hours after administration. Lymphocytes were isolated from blood samples before and 12 hours after drug administration to measure mRNA. As an animal experiment, an in situ intestinal injection with portal vein sampling model was used to examine the interaction between tanjin and rosuvastatin during the absorption phase. Rosuvastatin or rosuvastatin combined with tanjin solution was injected into the intestine. After injection, blood from the portal vein was collected and the concentration of rosuvastatin was measured by LC/MS/MS analysis. A portion of the intestine and liver from the rats was collected and stored at-80°C for mRNA measurement. Results In the clinical trial, co-administration of tanjin decreased the maximum plasma concentration (C max) of rosuvastatin by 26.85% compared with rosuvastatin alone, and also decreased the area under the plasma

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“…Noteworthy, Japanese and Korean people have one of the longest average life expectancies and display a lower risk of developing hypertension and cardiovascular diseases than other populations [ 23 , 24 ]. Some epidemiological studies suggested the existence of a causal correlation between these features and the regular consumption of seaweeds [ 10 , 25 , 26 ].…”

Section: Metabolic Syndrome Mechanisms and Comorbiditiesmentioning

confidence: 99%

Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

Gabbia

Martin

2020

Molecules

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Metabolic syndrome is characterized by the coexistence of different metabolic disorders which increase the risk of developing type 2 diabetes mellitus and cardiovascular diseases. Therefore, metabolic syndrome leads to a reduction in patients’ quality of life as well as to an increase in morbidity and mortality. In the last few decades, it has been demonstrated that seaweeds exert multiple beneficial effects by virtue of their micro- and macronutrient content, which could help in the management of cardiovascular and metabolic diseases. This review aims to provide an updated overview on the potential of brown seaweeds for the prevention and management of metabolic syndrome and its associated diseases, based on the most recent evidence obtained from in vitro and in vivo preclinical and clinical studies. Owing to their great potential for health benefits, brown seaweeds are successfully used in some nutraceuticals and functional foods for treating metabolic syndrome comorbidities. However, some issues still need to be tackled and deepened to improve the knowledge of their ADME/Tox profile in humans, in particular by finding validated indexes of their absorption and obtaining reliable information on their efficacy and long-term safety.

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Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan

Cited by 47 publications

References 37 publications

Seaweeds as nutraceuticals for health and nutrition

Seaweeds as nutraceuticals for health and nutrition

Pharmacokinetic Drug Interaction Between Rosuvastatin and Tanjin in Healthy Volunteers and Rats

Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

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