Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

Gabbia, Daniela; Martin, Sara De

doi:10.3390/molecules25184182

Cited by 39 publications

(35 citation statements)

References 186 publications

(249 reference statements)

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“…Red seaweed S. filiforme and Kappaphycus alvarezii, the producers of carrageenan, can be used as functional foods to relieve metabolic syndrome [35,101]. Many brown seaweeds also have good effects on metabolic syndrome management, owing to high amounts of MSPs in the total dry mass [102]. Sea cucumbers, abalone, and other animal seafood are rich in MSPs and other functional components, and they can also alleviate the metabolic syndrome induced by a high-fat diet [62,94].…”

Section: Therapeutic Methods and Dietary Interventionmentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.

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Section: Therapeutic Methods and Dietary Interventionmentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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“…Sea tangle (Laminaria japonica Aresch), a type of edible brown algae, has long been widely consumed as a food supplement and medicinal use in East Asia including Korea. This seaweed is rich in various lipophilic components, hydrophilic fibers, and minerals, and various pharmacological effects were extensively reported in several previous studies [11][12][13][14]. Interestingly, fermented sea tangle extract (FST) with Lactobacillus brevis BJ20 content 5.56% of gamma-aminobutyric acid (GABA) that was 49.5% among total free amino acids [15].…”

Section: Introductionmentioning

confidence: 95%

Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway

Kim

Cha

Hwangbo

et al. 2021

Foods

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The purpose of the present study was to explore the efficacy of fermented extract of sea tangle (Laminaria japonica Aresch, FST) with Lactobacillus brevis on DNA damage and apoptosis in hydrogen peroxide (H2O2)-stimulated osteoblastic MC3T3-E1 cells and clarify related signaling pathways. Our results showed that exposure to FST significantly improved cell viability, inhibited apoptosis, and suppressed the generation of reactive oxygen species (ROS) in H2O2-stimulated cells. In addition, H2O2 triggered DNA damage in MC3T3-E1 cells was markedly attenuated by FST pretreatment. Moreover, H2O2-induced mitochondrial dysfunctions associated with apoptotic events, including loss of mitochondrial membrane potential (MMP), decreased Bcl-2/Bcl-2 associated x-protein (Bax) ratio, and cytosolic release of cytochrome c, were reduced in the presence of FST. FST also diminished H2O2-induced activation of caspase-3, which was associated with the ability of FST to protect the degradation of poly (ADP-ribose) polymerase. Furthermore, FST notably enhanced nuclear translocation and phosphorylation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the presence of H2O2 with concomitant upregulation of heme oxygenase-1 (HO-1) expression. However, artificial blockade of this pathway by the HO-1 inhibitor, zinc protoporphyrin IX, greatly abolished the protective effect of FST against H2O2-induced MC3T3-E1 cell injury. Taken together, these results demonstrate that FST could protect MC3T3-E1 cells from H2O2-induced damage by maintaining mitochondrial function while eliminating ROS along with activation of the Nrf2/HO-1 antioxidant pathway.

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“…Among the brown seaweeds, "Ecklonia" and "Eisenia" genera have been reported to exert hypoglycemic effects through α-amylase and α-glucosidase inhibitory activities [30]. The observed hypoglycemic activity can be attributed to the presence of phlorotannins; eckol, dieckol, 6,6′-bieckol, phlorofucofuroeckol-A, and phloroglucinol, and 7-phloroeckol [31].…”

Section: Inhibitory Activity Of Carbohydrate Hydrolyzing α-Amylase and α-Glucosidase Enzymes A Brown Seaweedsmentioning

confidence: 99%

Advanced Pharmacological Uses of Marine Algae as an Anti-Diabetic Therapy

Gunathilaka¹,

Keertihirathna²,

Peiris³

2022

Natural Medicinal Plants

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Marine seaweeds are a promising source of bioactive secondary metabolites that can be utilized in drug development and nutraceuticals. Diabetes mellitus is a leading non-communicable disease, and it is the third leading cause of death worldwide. Among the types of diabetes, type 2 became the major health problem as it is associated with severe health complications. Since available oral hypoglycemic drugs cause several adverse effects, it is worth searching for a natural cure with fewer or no side effects that may benefit patients with type 2 diabetes. Among the marine seaweeds, brown and red seaweeds are extensively studied for the anti-diabetic activity compared to the green seaweeds. Bioactive compounds present in marine seaweeds possess anti-diabetic potential through diverse mechanisms, mainly by reducing postprandial hyperglycemia and associated complication. Most of the studies emphasized that the marine seaweeds control the hyperglycemic condition by inhibiting carbohydrate hydrolyzing α-amylase,α glucosidase enzymes, and the inhibitory effect of dipeptide peptidase-4 that are involved in the degradation of incretins. Similarly, bioactive compounds in marine seaweeds can reduce diabetes complications by inhibiting angiotensin-converting enzymes, aldose reductase, protein tyrosine phosphatase 1B enzyme. This chapter focuses on the anti-diabetic potential of marine brown, green, and red seaweeds through different mechanisms.

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Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

Cited by 39 publications

References 186 publications

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway

Advanced Pharmacological Uses of Marine Algae as an Anti-Diabetic Therapy

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