Use of TLC and RPTLC for separation of nicotinic acid derivatives

Pyka, Alina; Niestroj, Anna; Szarkowicz, Agnieszka; Śliwiok, J.

doi:10.1556/jpc.15.2002.6.3

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…In the past decades for NA qualitative and quantitative analysis, a variety of conventional analytical techniques had been used, mainly including paper chromatography, 15 thinlayer chromatography (TLC), [15][16][17] high performance thin-layer chromatography (HPTLC), [18][19][20][21] gas chromatography (GC) (limit of detection (LOD): 50.6-90.4 ng mL À1 ) [22][23][24] and gas chromatography/mass spectrometry (GC/MS) (LOD: 4.6-10.5 ng mL À1 ). [25][26][27] Paper chromatography, TLC and HPTLC are not sufficiently sensitive for the quantitative analysis of NA.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a method for the determination of nicotinic acid in human plasma using liquid chromatography-negative electrospray ionization tandem mass spectrometry and its application to a bioequivalence study

Huang

Shao

et al. 2014

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

Development and validation of a method for the determination of nicotinic acid in human plasma using liquid chromatography-negative electrospray ionization tandem mass spectrometry and its application to a bioequivalence study

Huang

Shao

et al. 2014

Anal. Methods

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“…Among the chiral topological indices (CTIs) published in the literature, Estrada and Uriarte mentioned some in a recent review about TIs 22. Those derived by Pyka,23–25 as well as Gutman and Pyka26 have rationalized some of these indices from a mathematical point of view. The relationships between these indices and the Wiener index have been established.…”

Section: Introductionmentioning

confidence: 99%

Bond‐based 3D‐chiral linear indices: Theory and QSAR applications to central chirality codification

et al. 2008

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The recently introduced non-stochastic and stochastic bond-based linear indices are been generalized to codify chemical structure information for chiral drugs, making use of a trigonometric 3D-chirality correction factor. These improved modified descriptors are applied to several well-known data sets to validate each one of them. Particularly, Cramer's steroid data set has become a benchmark for the assessment of novel quantitative structure activity relationship methods. This data set has been used by several researchers using 3D-QSAR approaches such as Comparative Molecular Field Analysis, Molecular Quantum Similarity Measures, Comparative Molecular Moment Analysis, E-state, Mapping Property Distributions of Molecular Surfaces, and so on. For that reason, it is selected by us for the sake of comparability. In addition, to evaluate the effectiveness of this novel approach in drug design we model the angiotensin-converting enzyme inhibitory activity of perindoprilate's sigma-stereoisomers combinatorial library, as well as codify information related to a pharmacological property highly dependent on the molecular symmetry of a set of seven pairs of chiral N-alkylated 3-(3-hydroxyphenyl)-piperidines that bind sigma-receptors. The validation of this method is achieved by comparison with earlier publications applied to the same data sets. The non-stochastic and stochastic bond-based 3D-chiral linear indices appear to provide a very interesting alternative to other more common 3D-QSAR descriptors.

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“…22 Among the chiral topological indices (CTIs) published in the literature, Estrada and Uriarte mentioned some in a recent review about TIs. 22 Those derived by Pyka, [23][24][25] as well as Gutman and Pyka 26 have rationalized some of these indices from a mathematical point of view. The relationships between these indices and the Wiener index have been established.…”

Section: Introductionmentioning

confidence: 99%

Bond-Based 3D-Chiral Linear Indices: Theory and QSAR Applications to Central Chirality Codification

Castillo-Garit

Marrero-Ponce

Torrensd

et al. 2008

Proceedings of the 12th International Electronic Conference on Synthetic Organic Chemistry

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The recently introduced non-stochastic and stochastic bond-based linear indices are been generalized to codify chemical structure information for chiral drugs, making use of a trigonometric 3D-chirality correction factor. These improved modified descriptors are applied to several well-known data sets to validate each one of them. Particularly, Cramer's steroid data set has become a benchmark for the assessment of novel quantitative structure activity relationship methods. This data set has been used by several researchers using 3D-QSAR approaches such as Comparative Molecular Field Analysis, Molecular Quantum Similarity Measures, Comparative Molecular Moment Analysis, E-state, Mapping Property Distributions of Molecular Surfaces, and so on. For that reason, it is selected by us for the sake of comparability. In addition, to evaluate the effectiveness of this novel approach in drug design we model the angiotensin-converting enzyme inhibitory activity of perindoprilate's r-stereoisomers combinatorial library, as well as codify information related to a pharmacological property highly dependent on the molecular symmetry of a set of seven pairs of chiral N-alkylated 3-(3-hydroxyphenyl)-piperidines that bind r-receptors. The validation of this method is achieved by comparison with earlier publications applied to the same data sets. The non-stochastic and stochastic bond-based 3D-chiral linear indices appear to provide a very interesting alternative to other more common 3D-QSAR descriptors. q

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Use of TLC and RPTLC for separation of nicotinic acid derivatives

Cited by 10 publications

References 15 publications

Development and validation of a method for the determination of nicotinic acid in human plasma using liquid chromatography-negative electrospray ionization tandem mass spectrometry and its application to a bioequivalence study

Development and validation of a method for the determination of nicotinic acid in human plasma using liquid chromatography-negative electrospray ionization tandem mass spectrometry and its application to a bioequivalence study

Bond‐based 3D‐chiral linear indices: Theory and QSAR applications to central chirality codification

Bond-Based 3D-Chiral Linear Indices: Theory and QSAR Applications to Central Chirality Codification

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