Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease

Allbutt, Haydn N.; Henderson, James W.

doi:10.1016/j.jneumeth.2006.07.006

Cited by 93 publications

(52 citation statements)

References 35 publications

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“…Interestingly, the administration of WA significantly reversed the DA and HVA levels in aged rats. Our previous study showed similar results after the treatment of PD animal model with WS root extract [22]. These data suggest that WA, an active component of WS, induces catecholamines in aged rats and is therefore able to establish its neuroprotective role.…”

Section: Discussionsupporting

confidence: 74%

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Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat

et al. 2018

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Withaferin A (WA) was evaluated for its neuro-protective efficacy on ageing induced striatal dopamine (DA) and behavioural changes in aged rats. Wistar albino rats were divided into group I – young (3 months), Group II – aged (24 months), Group III – aged rats supplemented with WA (50 mg/kg b.w once in a day for 30 days) and Group IV – young rats supplemented with WA (50 mg/kg b.w). The HPLC assay revealed significant decline in the levels of DA and homovanillic acid (HVA) in substantia nigra (SN) and striatum (ST) of aged rat. A marked decline in motor activity of aged rat was observed through open field, beam walking and grid walking motor experiments. These results indicate that ageing reduces nigro-striatal activity as well as nigro-striatal DA levels. Interestingly, the administration of WA (50 mg\kg b.w) resulted in a substantial resurge of DA and HVA in SN and ST and a significant reversal of motor impairment in aged rats. This study is the first report that evidently determines the neuro-protective efficacy of WA on dopaminergic system of SN and ST in aged rats.

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Section: Discussionsupporting

confidence: 74%

“…Our previous reports [14,22] have demonstrated the anti-oxidant potential of WS leaf extract through significant reduction of ROS and motor improvement by standard behavioural tests in animal models of PD. The present data distinctly demonstrates the significant DA depletion and concomitant motor functional impairment in aged rats.…”

Section: Discussionmentioning

confidence: 96%

Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat

et al. 2018

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“…Narrow beam walk test was used to measure hind limb impairment as described by Allbutt and Henderson [35]. Animals were trained on a 150-cm-long wooden beam, divided into three 50 cm segments, to transverse from a platform at one end to the home cage at the other end.…”

Section: Narrow Beam Walkmentioning

confidence: 99%

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

2011

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Evidence from clinical and experimental studies indicate that oxidative stress is involved in pathogenesis of Parkinson's disease. The present study was designed to investigate the neuroprotective potential of lycopene on oxidative stress and neurobehavioral abnormalities in rotenone induced PD. Rats were treated with rotenone (3 mg/kg body weight, intraperitoneally) for 30 days. NADH dehydrogenase a marker of rotenone action was observed to be significantly inhibited (35%) in striatum of treated animals. However, lycopene administration (10 mg/kg, orally) to the rotenone treated animals for 30 days increased the activity by 39% when compared to rotenone treated animals. Rotenone administration increased the MDA levels (75.15%) in striatum, whereas, lycopene administration to rotenone treated animals decreased the levels by 24.33%. Along with this, significant decrease in GSH levels (42.69%) was observed in rotenone treated animals. Lycopene supplementation on the other hand, increased the levels of GSH by 75.35% when compared with rotenone treated group. The activity of SOD was inhibited by 69% in rotenone treated animals and on lycopene supplementation; the activity increased by 12% when compared to controls. This was accompanied by cognitive and motor deficits in rotenone administered animals, which were reversed on lycopene treatment. Lycopene treatment also prevented release of cytochrome c from mitochondria. Collectively, these observations suggest that lycopene supplementation along with rotenone for 30 days prevented rotenone-induced alterations in antioxidants along with the prevention of rotenone induced oxidative stress and neurobehavioral deficits. The results provide an evidence for beneficial effect of lycopene supplementation in rotenone-induced PD and suggest therapeutic potential in neurodegenerative diseases involving accentuated oxidative stress.

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“…The narrow beam test was used to evaluate latency/akinesia and bradykinesia in the animals according to the a previously adapted method [14]. The beam, 100 cm long, 4 cm wide, and 2 cm thick was placed at a height of 100 cm above ground.…”

Section: Narrow Beam Testmentioning

confidence: 99%

“…Experimentally, the use of this toxin to induce an experimental model of the disease in rats is quite effective because it causes the death of dopaminergic neurons in the substantia nigra, triggering signals and morphologic changes that are very similar to those observed in patients with PD [4,[11][12][13]. The use of locomotor tests such as the narrow beam test is considered suitable for evaluating locomotor dysfunctions in animal models of PD [14].…”

Section: Introductionmentioning

confidence: 99%

Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease

et al. 2015

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Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease

Cited by 93 publications

References 35 publications

Ameliorative Effect of <b><i>Withaferin</i></b> <b><i>A</i></b> on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat

Ameliorative Effect of <b><i>Withaferin</i></b> <b><i>A</i></b> on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease

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