Use of the C-terminal octapeptide of cholecystokinin in clinical radiology

Abstract

Two 30-min. infusion doses of the octapeptide of chloecystokinin (C8-CCK) (1 and 4 ng/kg/min) produced equal and consistent gallbladder contractions (75 +/- 8% mean and SEM decrease in size) in 24 human volunteers. The long 30-min infusion method of C8-CCK administration appears better than bolus injection (30 to 180 s) for cholecystokinetic cholecystography.

Evaluation of intramuscular ceruletide for shortening small bowel transit time

“…The median time for ceruletide was 20 minutes compared to 45 minutes for placebo. Our results are similar to those of previous studies which have shown a significant decrease in transit time following both intravenous and intramuscular administration of ceruletide [24][25][26][27][28].…”

“…Of 31 studies, 3 (9.7%) were considered nondiagnostic. This is similar to previous reports using the octapeptide of cholecystokinin [24,25] and ceruletide [26]. However, we did not fill the upper small bowel with large amounts of barium optimally in every volunteer prior to drug administration.…”

“…Several pharmacologic agents have been given to patients to accelerate small bowel transit. These include subcutaneous prostigmin [2,3,10,12], intramuscular and intravenous administration of metoclopramide [13][14][15][16][17][18], cholecystokinin [19,20], sincalide [21 23], and ceruletide [24][25][26]. Of the pharmacologic agents, many have a significant number of contraindications.…”

“…Metoclopramide is contraindicated in the presence of gastrointestinal hemorrhage, mechanical obstruction, perforation, pheochromocytoma, epilepsy, and in patients receiving other drugs that are likely to cause extrapyramidal reactions [31]. Sincalide, the C-terminal octapeptide of cholecystokinin, has no contraindication other than a history of sensitivity to the drug [23][24][25]32].…”

“…The filming sequence was terminated at 60 minutes for 2 reasons. Ideally one would like a small bowel examination completed by 1 hour, and more importantly, it has been shown in prior studies with both ceruletide and sincalide that the drugs' action on the small bowel lasts for only 30-45 minutes [23][24][25][26][27][28] (Fig. 2).…”