Use of tDCS in Aphasia Rehabilitation: A Systematic Review of the Behavioral Interventions Implemented With Noninvasive Brain Stimulation for Language Recovery

Galletta, Elizabeth E.; Conner, Peggy S.; Vogel-Eyny, Amy; Marangolo, Paola

doi:10.1044/2016_ajslp-15-0133

Cited by 24 publications

(17 citation statements)

References 78 publications

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“…Transcranial direct current stimulation (tDCS) is proposed as an economical and non-invasive method of enhancing recovery after stroke when paired with behavioural training [1][2][3][4][5][6][7][8][9][10]. However, the effects of tDCS vary substantially across individuals [11,12] making adoption into routine clinical practice difficult.…”

Section: Introductionmentioning

confidence: 99%

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The impact of brain lesions on tDCS-induced electric field magnitude

Johnstone

Zich

Evans

et al. 2021

Preprint

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Background: Transcranial direct current stimulation (tDCS) has been used to enhance motor and language rehabilitation following a stroke. However, improving the effectiveness of clinical tDCS protocols depends on understanding how a lesion may influence tDCS-induced current flow through the brain. Objective: We systematically investigated the effect of brain lesions on the magnitude of electric fields (e-mag) induced by tDCS. Methods: We simulated the effect of 630 different lesions - by varying lesion location, distance from the region of interest (ROI), size and conductivity - on tDCS-induced e-mag. We used current flow models in the brains of two participants, for two commonly used tDCS montages, targeting either primary motor cortex (M1) or Brocas area (BA44) as ROIs. Results: The effect on absolute e-mag change was highly dependent on lesion size, conductance and distance from ROI. Larger lesions, with high conductivity, close to the ROI caused e-mag changes of more than 30%. The sign of this change was determined by the location of the lesion. Specifically, lesions located in-line with the predominant direction of current flow increased e-mag in the ROI, whereas lesions located in the opposite direction caused a decrease. Conclusions: These results demonstrate that tDCS-induced electric fields are profoundly influenced by lesion characteristics. This highlights the need for individualised targeting and dose control in stroke. Additionally, the variation in electrical fields caused by assigned conductance of the lesion underlines the need for improved estimates of lesion conductivity for current flow models.

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Section: Introductionmentioning

confidence: 99%

“…Specifically, we placed electrodes over 10-05 coordinates Fp2 and CCP3 for both participants. For the other montage, often used in aphasia rehabilitation studies[7,8] to target BA44, the anode is positioned over left frontal cortex (BA44) and the…”

mentioning

confidence: 99%

The impact of brain lesions on tDCS-induced electric field magnitude

Johnstone

Zich

Evans

et al. 2021

Preprint

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“…As results of the acute neurological events related to COVID-19 infection, functional outcomes of patients surviving an ICU admission report also a high prevalence of speech, language and cognitive-communication disorders (Avula et al, 2020). tDCS has been previously applied concurrently with speech therapy for language recovery in aphasia (Galletta et al, 2016;Fridriksson et al, 2018Fridriksson et al, , 2019.…”

Section: Role In Post-acute Recovery Of Functionmentioning

confidence: 99%

Update on the Use of Transcranial Electrical Brain Stimulation to Manage Acute and Chronic COVID-19 Symptoms

Pilloni

Bikson

Badran

et al. 2020

Front. Hum. Neurosci.

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The coronavirus disease 19 (COVID-19) pandemic has resulted in the urgent need to develop and deploy treatment approaches that can minimize mortality and morbidity. As infection, resulting illness, and the often prolonged recovery period continue to be characterized, therapeutic roles for transcranial electrical stimulation (tES) have emerged as promising non-pharmacological interventions. tES techniques have established therapeutic potential for managing a range of conditions relevant to COVID-19 illness and recovery, and may further be relevant for the general management of increased mental health problems during this time. Furthermore, these tES techniques can be inexpensive, portable, and allow for trained self-administration. Here, we summarize the rationale for using tES techniques, specifically transcranial Direct Current Stimulation (tDCS), across the COVID-19 clinical course, and index ongoing efforts to evaluate the inclusion of tES optimal clinical care.

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“…But only a few studies have investigated whether the positive effect may be further enhanced by combining excitatory stimulation of the left hemisphere and inhibitory stimulation of the right hemisphere. Existing studies (Lee et al, 2013;Marangolo et al, 2016) have found positive effects of such bilateral stimulation. However, to the best of our knowledge, no studies have used both necessary control conditions, testing whether the effect of bilateral stimulation is superior to both excitatory stimulation of the left hemisphere only and to inhibitory stimulation of the right hemisphere only.…”

Section: Introductionmentioning

confidence: 99%

“…Transcranial direct current stimulation (tDCS) is a safe and tolerable brain stimulation method that has a high potential for routine clinical use to increase the gains of behavioral aphasia treatment (Galletta et al, 2016). However, it remains largely unknown which stimulation settings and targets provide the greatest therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%