Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice

Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

“…lactis strain was able to prevent tumor appearance in the colon [118]. In another study, we have shown that a catalase producing strain of L. casei BL23 significantly decreased the physiological damages caused by the TNBS administration [121]. This result is similar to those obtained previously where it was shown that both the native strain of L. casei BL23 and its catalase producing derivative presented a significant reduction of caecal and colonic inflammatory scores [117].…”

“…Another experimental study demonstrated that L. gasseri producing manganese SOD had significant antiinflammatory activity reducing the severity of colitis in IL-10-deficient mice [8]. Recent data has shown that SOD producing L. casei BL23 was able to significantly attenuate the TNBS-induced damages as shown by higher survival rates, decreased animal weight loss, lower bacterial translocation to the liver and the prevention of damage to the large intestines [121]. This is in agreement with previous results that have shown that the same SOD-expressing strain of L. casei was able to slightly attenuate the colonic histological damage score of a DSS-induced colitis model [122].…”

“…Attenuation of the severity of inflammation in CD patients [102] Regulation of inflammatory cascades in an asthma model [103] CAT L. casei BL23 MnKat Reduction of cecal and colonic inflammatory scores in a DSS-induced colitis model [117] Significat reduction of physiological damages in a TNBS-induced colitis model [121] Lc. lactis + KatE Significat reduction of physiological damages in a TNBS-induced colitis model.…”

Modification in the diet can induce beneficial effects against breast cancer

“…The benefits of probiotics on the gut immune system in the prevention of cancer has also been previously described [73,74] . There are many different mechanisms by which probiotics and fermented products containing viable LAB may lower the risk of colon cancer; among them, the modulation of the intestinal microbiota [75][76][77][78][79][80] , the inactivation of carcinogenic compound [81][82][83] , anti-oxidant effects [84][85][86] , and the modulations of the host's immune response [87][88][89] . Recently, the administration of probiotic Dahi containing Lactobacillus (L.) acidophilus LaVK2 and Bifidobacterium bifidum BbVK3 alone or in combination of piroxicam showed anti-neoplastic and anti-proliferative activities in a model of DMH-induced CRC in rats [90] .…”

Prospective Uses of Genetically Engineered Lactic Acid Bacteria for the Prevention of Inflammatory Bowel Diseases

“…An increasing number of probiotic strains have shown to highly increase s-IgA, therefore the stimulation of IgA-producing cells is often considered a must in probiotic screening trials (O'Sullivan, 2001). Numerous studies have shown that certain strains of lactobacilli and bifidobacteria can modulate the production of cytokines (mediators produced by immune cells) that are involved in the regulation, activation, growth, and differentiation of immune cells and have been recently reviewed (de Moreno de LeBlanc et al, 2011). These probiotic microorganisms are able to prevent and treat certain inflammatory diseases in the gastrointestinal tract through the repression of pro-inflammatory cytokines.…”