Use of sodium hyaluronate in treating temporomandibular joint disorders: A randomized, double-blind, placebo-controlled clinical trial

Evaluation of efficacy of arthrocentesis (with normal saline) with or without sodium hyaluronate in treatment of internal derangement of TMJ – A prospective randomized study in 20 patients

“…It provides lubrication for the articular surfaces and is largely responsible for synovial fluid viscosity. 18 According to our study average age of patients of internal derangement who attended the clinic ranges from 15 to 25 years.…”

“…In various studies Kopp etal, 17 Bertolami et al 18 (1993) found the significant improvement in subjective symptoms after sodium hyaluronate injection.…”

O uso do hialuronato de sódio no tratamento das disfunções temporomandibulares articulares

“…Considering HA properties, viscosuplementation with HA has been used in different joint TMDs, such as reducing and nonreducing disc displacement, osteoarthritis and degenerative joint disease 16,17,20,21,23,[34][35][36][37][38] . A multicenter study 16 involved a sample of 121 participants divided in two parallel groups, who were followed up for six months. Participants had documented diagnosis of TMJ intraarticular disease with severe dysfunction and with unfavorable results of conservative therapies to which they were submitted for at least six months.…”

“…In addition to all described benefits, sodium hyalorunate infiltration, alone or associated to surgical procedures, is a simple, fast and minimally invasive treatment, does not leave scars, does not need sophisticated tools, materials and equipment, does not require hospitalization and may be performed under local anesthesia in outpatient settings or in the dental office itself. These aspects, together with its safety and efficacy profile, in addition to few adverse and transient effects, have motivated professionals to elect SH infiltration directly in the TMJ for several joint disorders 10,16,18,25 (level of evidence 2, 2, 3 and 3, respectively).…”

“…MPs act on collagen and proteoglycans, weakening joint cartilage matrix. Thus, there are collagen and proteoglycan fragments, in addition to leukotriens and cytokines in the capsular ligament, leading to joint movement limitation and followed or not by pain [16][17][18][19] . TMJ viscosuplementation is a minimally invasive technique consisting in intra-articular injection of HA (sodium hyalorunate) aiming at eliminating or decreasing pain and providing joint functional gain, promoting qualitative and quantitative improvement of the synovial fluid [20][21][22] .…”