Use of silicon nanoparticle surface coating in infection control: Experience in a tropical healthcare setting

Karunanayake, Lilani; Waniganayake, Yasindu Chathurangi; Gunawardena, Kuruwitage Dona Nirmala; Padmaraja, Sellapperuma Achchige Danuka; Peter, Dilanie; Jayasekera, Rohana; Karunanayake, Panduka

doi:10.1016/j.idh.2019.06.006

Cited by 6 publications

(6 citation statements)

References 30 publications

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“…Contaminated surfaces in public places, such as hospitals, parks, public transportation and schools, are a well-recognized common source for outbreaks of infection [46,47]. Some studies have shown the potential of nano-based surface coatings for prevention of infections [48][49][50]. Also, the protection of healthcare workers is very important in a viral outbreak.…”

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confidence: 99%

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

et al. 2020

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Incidents of viral outbreaks have increased at an alarming rate over the past decades. The most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread around the world and shown R 0 values from 2.2 to 2.68. However, the ratio between mortality and number of infections seems to be lower in this case in comparison to other human coronaviruses (such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV)). These outbreaks have tested the limits of healthcare systems and have posed serious questions about management using conventional therapies and diagnostic tools. In this regard, the use of nanotechnology offers new opportunities for the development of novel strategies in terms of prevention, diagnosis and treatment of COVID-19 and other viral infections. In this review, we discuss the use of nanotechnology for COVID-19 virus management by the development of nano-based materials, such as disinfectants, personal protective equipment, diagnostic systems and nanocarrier systems, for treatments and vaccine development, as well as the challenges and drawbacks that need addressing.

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confidence: 99%

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

et al. 2020

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“…Contaminated objects in public areas, such as hospitals, parks, public transit, and schools, are a well-known widespread cause of infection [40,41]. Some experiments have demonstrated the ability of nano-based surface coatings to eliminate infections [42,43].…”

Section: Structurementioning

confidence: 99%

Nanomedicine for COVID-19: the role of nanotechnology in the treatment and diagnosis of COVID-19

Vahedifard

Chakravarthy

2021

emergent mater.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the recent outbreak of coronavirus 2019 (COVID-19). Although nearly two decades have passed since the emergence of pandemics such as SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), no effective drug against the CoV family has yet been approved, so there is a need to find newer therapeutic targets. Currently, simultaneous research across the globe is being performed to discover efficient vaccines or drugs, including both conventional therapies used to treat previous similar diseases and emerging therapies like nanomedicine. Nanomedicine has already proven its value through its application drug delivery and nanosensors in other diseases. Nanomedicine and its components can play an important role in various stages of prevention, diagnosis, treatment, vaccination, and research related to COVID-19. Nano-based antimicrobial technology can be integrated into personal equipment for the greater safety of healthcare workers and people. Various nanomaterials such as quantum dots can be used as biosensors to diagnose COVID-19. Nanotechnology offers benefits from the use of nanosystems, such as liposomes, polymeric and lipid nanoparticles, metallic nanoparticles, and micelles, for drug encapsulation, and facilitates the improvement of pharmacological drug properties. Antiviral functions for nanoparticles can target the binding, entry, replication, and budding of COVID-19. The toxicity-related inorganic nanoparticles are one of the limiting factors of its use that should be further investigated and modified. In this review, we are going to discuss nanomedicine options for COVID-19 management, similar applications for related viral diseases, and their gap of knowledge.

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“…Sodium hypochlorite disinfection, which comprised any disinfection method specified as bleach or sodium hypochlorite, was identified in 19% of studies [20,44,60 For surface interventions, we found that copper surfaces were in 9% of studies [90,132,152,154,[167][168][169][170][171][172][173][174][175][176][177][178][179]. Other non-copper surface applications or coatings comprised 8% of studies [87,102,[180][181][182][183][184][185][186][187][188][189][190][191][192]. Other non-copper surfaces included coatings incorporating metals such as titanium oxide and silver ions as well as other coatings comprised of polymers, isopropyl alcohol and organofunctional silane, organosilane products, silicon nano-coating inorganic metal and organic quaternary ammonium, silicone quaternary amine, quaternary ammonium silyl oxide, and titanyl oxide moieties.…”

Section: Disinfection Typementioning

confidence: 99%

Evidence Map and Systematic Review of Disinfection Efficacy on Environmental Surfaces in Healthcare Facilities

Christenson¹,

Cronk

Atkinson³

et al. 2021

IJERPH

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Healthcare-associated infections (HAIs) contribute to patient morbidity and mortality with an estimated 1.7 million infections and 99,000 deaths costing USD $28–34 billion annually in the United States alone. There is little understanding as to if current environmental surface disinfection practices reduce pathogen load, and subsequently HAIs, in critical care settings. This evidence map includes a systematic review on the efficacy of disinfecting environmental surfaces in healthcare facilities. We screened 17,064 abstracts, 635 full texts, and included 181 articles for data extraction and study quality assessment. We reviewed ten disinfectant types and compared disinfectants with respect to study design, outcome organism, and fourteen indictors of study quality. We found important areas for improvement and gaps in the research related to study design, implementation, and analysis. Implementation of disinfection, a determinant of disinfection outcomes, was not measured in most studies and few studies assessed fungi or viruses. Assessing and comparing disinfection efficacy was impeded by study heterogeneity; however, we catalogued the outcomes and results for each disinfection type. We concluded that guidelines for disinfectant use are primarily based on laboratory data rather than a systematic review of in situ disinfection efficacy. It is critically important for practitioners and researchers to consider system-level efficacy and not just the efficacy of the disinfectant.

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Use of silicon nanoparticle surface coating in infection control: Experience in a tropical healthcare setting

Cited by 6 publications

References 30 publications

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

Nanomedicine for COVID-19: the role of nanotechnology in the treatment and diagnosis of COVID-19

Evidence Map and Systematic Review of Disinfection Efficacy on Environmental Surfaces in Healthcare Facilities

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