Use of Serum Cistatin C Determination as a Marker of Renal Function in the Dog

Abstract

2005. Use of serum cistatin C determination as a marker of renal function in the dog. Veterinary Research Communications, 29(Suppl. 2), 265-267

Usefulness of Serum Cystatin C Measurement for Assessing Renal Function in Cats

“…The problem regarding advantage of Penia method over the elder Petia method and the difference in the results obtained according to the chosen method was described by Jonkisz et al (13). Factors such as age, sex, or body weight did not affect cystatin C serum concentration in cats, which remains in agreement with the results reported by other authors (2,10,21,24) In conclusion, the data obtained for the examined population of cats indicate that reference values for serum concentration of cystatin C in healthy cats do not exceed the range of 0.3 to 1.1 mg/L. The factors such as age, sex, and body weight do not affect the serum concentration of cystatin C. Analysis of the obtained results, based on ROC curve, proved that cystatin C seems to be a more advantageous parameter than creatinine in the assessment of renal function diagnosis in cats.…”

Serum Cystatin-C Evaluation in Dogs Affected by Different Diseases Associated or Not with Renal Insufficiency

“…This study emphasized that sCys-C can be evaluated in dog serum samples using the PENIA method with an analytical kit developed for human application, as we (Antognoni et al, 2005) and other authors (Mareš et al, 2003;Herget-Rosenthal et al, 2005) have previously described. Based on these results and on those we previously found (sCys-C=0.25T0.14 mg/L) we propose 0.25T0.15 mg/L as the reference range for dogs without renal disfunction (gB).…”

“…In human medicine Cys-C evaluation is able to detect an earlier stage of decreased glomerular filtration rate (GFR) than other parameters (serum creatinine, creatinine clearanced etc) and it is considered particularly useful in patients with a high risk of developing nephropaties (Xia et al, 2004;Uslu et al, 2005), such as those affected by diabetes or who have undergone an organ transplantation (Mareš et al, 2003;Herget-Rosenthal et al, 2005). Given the few studies related to the clinical meaning of Cys-C in veterinary medicine (Jensen et al, 2001;Almy et al, 2002;Braun et al, 2002) and the limited but encouraging preliminary results of a prior study of ours and a related note (Antognoni et al, 2005), we present further observations on both dogs affected by hyperazotemic renal failure and diseases not associated with overt renal dysfunction.…”

Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis

“…Over several years serum levels of Cys-C have been considered as a signifi cant marker for fi ltration rate, and the blood protein Cys-C is believed to be an important endogenous marker of RF [17]. Cys-C is a low molecular weight (14 kD) basic protein of the cystatin super family, inhibitors of cystein-proteases, which is produced at a constant rate by all nucleated cells [18].…”