Use of Sephadex column chromatography in the assessment of thyroid status

Gimlette, T. M. D.

doi:10.1136/jcp.20.2.170

Cited by 22 publications

(6 citation statements)

References 5 publications

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“…Patients taking cardiac glycosides were excluded. The diagnosis of thyrotoxicosis was made on clinical grounds and confirmed by two or more of the following tests: 20-minute uptake of 99mTc by the thyroid (De Garreta et al, 1968), serum proteinbound iodine, serum thyroxine, and T3-Sephadex uptake (Gimlette, 1967).…”

Section: Methodsmentioning

confidence: 99%

Red Cell Sodium in Hyperthyroidism

Goolden¹,

Bateman²,

Torr³

1971

BMJ

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Section: Methodsmentioning

confidence: 99%

Red Cell Sodium in Hyperthyroidism

Goolden¹,

Bateman²,

Torr³

1971

BMJ

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“…The tests were repeated on the 8th day of life. Plasma-bound iodine was estimated by Auto-analyser The 131I tri-iodothyronine (T,) resin uptake test was estimated after the method of Gimlette (1967). The T, adult euthyroid range is for this laboratory 70-140%.…”

Section: Methodsmentioning

confidence: 99%

Thyroid Function Tests in the Newborn

Chadd¹,

Gray²,

Davies³

1970

Archives of Disease in Childhood

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. (1970). Archives of Disease in Childhood, 45, 374. Thyroid function tests in the newborn. The 131I triiodothyronine (T3) resin uptake test reflects thyroid function more closely than other acceptable tests currently available.The T3 uptake and protein-bound iodine (PBI) level were estimated in 20 premature and 20 full-term infants at birth and at the end of 1 week.The full-term infant has normal adult values, whereas the premature baby has results extending into the hyperthyroid range at birth, but these fall to within normal limits at 1 week.There are few studies of thyroid function in the newborn and neonatal period of infants bom earlier than the 37th week of gestation. Proteinbound iodine (PBI) levels are similar to those obtained for full-term infants (Danowski et al., 1950). The radioactive iodine (1311) uptake test has limited value because of the risk from irradiation.The in vitro test of radioactive 131I-labelled triiodothyronine uptake using red blood cells was introduced by Hamolsky, Stein, and Freedberg (1957). A similar test was used by later workers using a resin substituted for red blood cells (Nava and De Groot, 1962;Godden and Garnett, 1964 The tests were repeated on the 8th day of life. Plasma-bound iodine was estimated by Auto-analyser The 131I tri-iodothyronine (T,) resin uptake test was estimated after the method of Gimlette (1967). The T, adult euthyroid range is for this laboratory 70-140%.The T3 test can now be performed on as little as 0 1 ml. plasma. ResultsThe PBI levels in both the full-term and premature infants confirm the known high mean and wide ranges of cord blood, with even higher levels at the end of the first week (Table). However, T3 resin uptake is normal for the full-term infants both at birth and at the end of the first week. The premature infants' cord results show a high mean with a very wide range at birth, but by the end of the first week these results also show a normal mean and range.The mean cord blood PBI in both term and premature infants is at the upper limit of adult normal euthyroid values (3*5 fig.-8 0 tzg./100 ml.

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“…Indeed, during the period in which our patient's immunoglobulins were being estimated she Thyroid Studies The serum protein-bound iodine (Riley and Gochman, 1964) was reduced at 2-5 ttg/100 ml, on 2 occasions. This low result was not the consequence of a deficiency of a thyroxine binding globulin because a T3 resin uptake (Gimlette, 1967) was in the hypothyroid range at 0-028. There was no evidence of auto-antibodies to the thyroid from the complement fixation test (Roitt and Doniach, 1958) or from the tanned red-cell haemagglutination test (Fulthorpe et al, 1961).…”

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confidence: 88%

Deletion of the long arms of chromosome 18 (46,XX,18q-) associated with absence of IgA and hypothyroidism in an adult.

Faed¹,

Whyte²,

Paterson³

et al. 1972

Journal of Medical Genetics

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London et al (1964) recorded the case of a 28-yearold woman who had menstrual periods for 5 years and then became amenorrhoeic. He assumed thai the XX cells had to be present for the ovaries tc function regularly as indicated by normal menstruation. If there is a lack of these XX cells primary amenorrhoea will occur and if the XX cells arc 'used up' then the amenorrhoea will be secondary. Summary A case is reported of a 20-year-old woman with a 45,X complement, with dwarfism and numerous other signs of Turner's syndrome, who has been menstruating for the past five years.The question remains whether a single X-chromosome is sufficient for fertility or whether a mosaic pattern has to be suspected in the ovaries of fertile females with Turner's syndrome.

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Use of Sephadex column chromatography in the assessment of thyroid status

Cited by 22 publications

References 5 publications

Red Cell Sodium in Hyperthyroidism

Red Cell Sodium in Hyperthyroidism

Thyroid Function Tests in the Newborn

Deletion of the long arms of chromosome 18 (46,XX,18q-) associated with absence of IgA and hypothyroidism in an adult.

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