Red Cell Sodium in Hyperthyroidism

Goolden, A. W. G.; Bateman, Diana; Torr, S

doi:10.1136/bmj.2.5761.552

Cited by 38 publications

(8 citation statements)

References 12 publications

(7 reference statements)

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“…Patients with obesity (De Luise et al 1980 ;Klimes et al 1982), myotonic muscular dystrophy (Lomber et al 1981) and uremia (Smith and Welt 1976) were shown to have fewer pump units than controls. In hyperthyroid patients, reduced activity of the erythrocyte sodium pump has been suggested by several investigators because of an elevated concentration of sodium within their erythrocytes (Boeckelman 1958 ;Goolden et al 1971). Cole and Waddell (1976) confirmed these findings by measuring ouabain-sensitive ATPase activity in erythrocyte membranes from hyperthyroid patients.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte ouabain binding capacity as a possible cellular index of hyperthyroid status.

Suzuki¹,

Kadowaki²,

Sekimizu³

et al. 1983

Endocrinol Japon

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Section: Discussionmentioning

confidence: 99%

Erythrocyte ouabain binding capacity as a possible cellular index of hyperthyroid status.

Suzuki¹,

Kadowaki²,

Sekimizu³

et al. 1983

Endocrinol Japon

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“…These include hyperthyroidism [21], severe cardiac failure [19], sick cell syndrome [17], metabolic alkalosis [22], thalassaemia [23], and Na depletion. Czaczkes et al [19] found RBC-Na to be low in uraemia, but Welt et al [24] described a group of patients with very high RBC-Na levels.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Electrolyte Content and Sodium Efflux in Chronic Renal Failure

Jessop

Eales

1977

Nephron

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The cation content of the erythrocyte was studied in 36 patients with chronic renal failure. A normal or high erythrocyte potassium was found. Erythrocyte sodium values showed a wide range, from very high to very low, and the rate constant for Na efflux was found to be higher than normal. The interpretation of these findings is discussed. It is suggested that the high erythrocyte K content may reflect abnormal total body K, may be explained on the basis of a young red cell population or may be related to abnormal function of the erythrocyte cation pump. It is probable that the development of these changes in chronic renal failure depends on many factors.

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“…Thyroidal hyperactivity was shown by elevated 'I uptake (4-h was 26%, 24-h was 43%) and [181I] PBI (0.14% of dose/liter at 48 h). Peripheral hyperthyroidism, that is excessive effect of thyroid hormone on peripheral tissues, was documented by elevated BMR of + 20% (18), shortened pulse-wave arrival time (QKd interval) of 135 ms (19), and elevated red cell sodium content of 9.4 mmol/liter of cells (20).…”

Section: Methodsmentioning

confidence: 99%