Use of risk-based cervical screening programs in resource-limited settings

Design of the HPV-Automated Visual Evaluation (PAVE) Study: Validating a Novel Cervical Screening Strategy

“…4 There is a growing consensus that to achieve broad screening coverage, HPV testing of self-collected cervicovaginal specimens would be optimal for many populations. 3,4,7,11 The results from meta-analyses comparing the performance of self-collected to clinician-collected samples, using PCR-based HPV detection, showed similar sensitivity and specificity for the detection of cervical precancer. 11 As of 2022, seven LMIC were recommending HPV self-collection.…”

“…The US Cancer Moonshot initiative for Accelerated Control of Cervical Cancer has supported development of the new screening methods. 7…”

Design of the HPV-automated visual evaluation (PAVE) study: Validating a novel cervical screening strategy

“…However, the rapid implementation of a broad, effective cervical screening campaign for adult women in the highest-burden areas will advance cancer control by 20 years ( Figure 1 ). The U.S. Cancer Moonshot initiative for Accelerated Control of Cervical Cancer has supported development of the new screening methods ( Perkins et al, 2023 ).…”

“…We considered cervical cancer deaths averted over the lifetime of cohorts subject to the intervention, and conservatively assumed that deaths averted due to screening would only occur after age 50, to account for prevalent cancers. Projections were developed for the ~65 low- and middle-income countries (LMIC) with age-standardized cervical cancer incidence greater than 10 per 100,000 women ( Perkins et al, 2023 ). For each country, we assumed that, in the absence of any intervention, the number of cervical cancer deaths for each 5 year age group would apply each year for the lifetime of the selected birth cohorts ( Perkins et al, 2023 ).…”

“…Projections were developed for the ~65 low- and middle-income countries (LMIC) with age-standardized cervical cancer incidence greater than 10 per 100,000 women ( Perkins et al, 2023 ). For each country, we assumed that, in the absence of any intervention, the number of cervical cancer deaths for each 5 year age group would apply each year for the lifetime of the selected birth cohorts ( Perkins et al, 2023 ). We conservatively and crudely assumed that screening and management would avert 25% of cervical cancer deaths (equivalent to screening uptake of 40% of eligible women, with 62.5% of screen-positive women receiving appropriate management) beginning at age 50 years.…”