Use of response surface methodology to optimize culture medium for production of lovastatin by Monascus ruber

Chang, Yaw-Nan; Huang, Jen-Chang; Lee, Chih-Chen; Shih, Ing-Lung; Tzeng, Yew‐Min

doi:10.1016/s0141-0229(02)00037-6

Cited by 96 publications

(71 citation statements)

References 19 publications

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“…Statistical optimization not only allows quick screening of a large experimental domain, but also refl ects the role of each of fl the components. Response Surface Methodology (RSM), a collection of mathematical and statistical techniques for building empirical models 11 , is gaining importance for optimizing conditions for the production of industrially important products such as chemicals and enzymes [12][13][14][15] and for studying enzyme kinetics 16 . Here the term ''optimum conditions'' means the operating conditions for maximizing the production of enzymes.…”

Section: Introductionmentioning

confidence: 99%

Statistical optimization of alkaline xylanase production from Streptomyces violaceoruber under submerged fermentation using response surface methodology

et al. 2007

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Response surface methodology employing central composite design (CCD) was used to optimize fermentation medium for the production of cellulase-free, alkaline xylanase from Streptomyces violaceoruber under r submerged fermentation. The design was employed by selecting wheat bran, peptone, beef extract, incubation time and agitation as model factors. A second-order quadratic model and response surface method showed that the optimum conditions for xylanase production (wheat bran 3.5 % (w/v), peptone 0.8 % (w/v), beef extract 0.8 % (w/v), incubation time 36 h and agitation 250 rpm) results in 3.0-fold improvement in alkaline xylanase production (1500.0 IUml -1 ) as compared to initial level (500.0 IUml -1 ) after 36 h of fermentation, whereas its value predicted by the quadratic model was 1347 IUml -1 . Analysis of variance (ANOVA) showed a high coefficient of determination (R fi 2 ) value of 0.9718, ensuring a satisfactory adjustment of the quadratic model with the experimental data.The economical and cellulase-free nature of xylanase would enhance its applicability in pulp and paper industry.

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Section: Introductionmentioning

confidence: 99%

Statistical optimization of alkaline xylanase production from Streptomyces violaceoruber under submerged fermentation using response surface methodology

et al. 2007

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“…; E-mail: mali_hamdard@yahoo.co.in Production of angkak by Monascus sp nutraceutical or health functional food (4,11,22). During process optimization, screening or selection of important parameters influencing fermentation productivity is initially carried out by barrowing method or by Plackett-Burman design, and finally the screened parameters are optimized using different advanced statistical techniques (3,7,8,15). Response surface methodology (RSM) is a widely used technique for optimization of fermentation process parameters.…”

Section: A Previous Study On Red Mold Rice Production Bymentioning

confidence: 99%

“…Fungal cultures were maintained routinely on potato dextrose agar (PDA) medium and subcultured in every 30 d interval (3,19).…”

Section: Cultures Of Monascus Purpureus Mtcc 369 Andmentioning

confidence: 99%

“…Therefore these four medium parameters were chosen for further optimization by response surface methodology (3,19,20). The various levels of nutrients are summarized in Table 4.…”

Section: Screening Of Nutrient Parametersmentioning

confidence: 99%

“…Angkak (red mold rice, red yeast rice, Chinese red rice) is a traditional Chinese medicine produced by solid-state fermentation of cooked non-glutinous rice (Orizae sativa L. (3,6,9,14). The angkak has long been recognized as a folk medicine for improving food digestion and blood circulation and for treatment of muscle bruising and dysentery.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Production of angkak through co-culture of Monascus purpureus and Monascus ruber

Panda¹,

Javed²,

Ali³

2010

Braz. J. Microbiol.

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Angkak (red mold rice, red yeast rice, Chinese red rice) is a traditional Chinese medicine produced by solid-state fermentation of cooked non-glutinous rice with Monascus species. The secondary metabolite of Monascus species, monacolin K /lovastatin, has been proven to lower blood lipid levels. In this study, a coculture of Monascus purpureus MTCC 369 and Monascus ruber MTCC 1880 was used for angkak production. Four medium parameters screened by Plackett-Burman design were optimized by response surface methodology for highest lovastatin production in angkak during solid-state fermentation by the coculture. Maximum lovastatin production of 2.84 mg g -1 was predicted in solid medium containing 20 g rice and 40 ml liquid nutrients medium (malt extract 9.68 g l

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Optimization of the preparation of a poly(aspartic acid) superabsorbent resin with response surface methodology

Zhao

Tan

2006

J of Applied Polymer Sci

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A poly(aspartic acid) superabsorbent resin was synthesized with polysuccinimide through chemical crosslinking with a crosslinking agent (diamine). The optimization of its preparation was investigated with response surface methodology. According to the Plackett-Burman design, the crosslinking temperature, drying temperature, and dissolving time of polysuccinimide had significant influences on the swelling ratio of the poly(aspartic acid) resin, which was the criterion for describing the water absorption capacity. Central composite design and response surface analysis were employed subsequently to further optimize the three aforementioned factors. A maximum swelling ratio greater than 500 g/g was attained; this was more than a 60% increase in comparison with previous results.

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Use of response surface methodology to optimize culture medium for production of lovastatin by Monascus ruber

Cited by 96 publications

References 19 publications

Statistical optimization of alkaline xylanase production from Streptomyces violaceoruber under submerged fermentation using response surface methodology

Statistical optimization of alkaline xylanase production from Streptomyces violaceoruber under submerged fermentation using response surface methodology

Production of angkak through co-culture of Monascus purpureus and Monascus ruber

Optimization of the preparation of a poly(aspartic acid) superabsorbent resin with response surface methodology

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