Use of Quinolones in Urinary Tract Infection and Prostatitis

Nicolle, Lindsay E.

doi:10.1016/b978-012059517-4/50007-6

Cited by 8 publications

(6 citation statements)

References 92 publications

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“…In the present study, we investigated both the pharmacokinetics in plasma, and urine and the urinary bactericidal activity (as urinary bactericidal titers) after single oral doses of gatifloxacin (400 mg) and ciprofloxacin (500 mg); the latter having been in clinical use for two decades and can still be considered as a drug of choice for the treatment of uncomplicated and complicated UTI [18].…”

Section: Discussionmentioning

confidence: 99%

Urinary bactericidal activity, urinary excretion and plasma concentrations of gatifloxacin (400 mg) versus ciprofloxacin (500 mg) in healthy volunteers after a single oral dose

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Kinzig‐Schippers

et al. 2004

International Journal of Antimicrobial Agents

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Section: Discussionmentioning

confidence: 99%

Urinary bactericidal activity, urinary excretion and plasma concentrations of gatifloxacin (400 mg) versus ciprofloxacin (500 mg) in healthy volunteers after a single oral dose

Boy

Well

Kinzig‐Schippers

et al. 2004

International Journal of Antimicrobial Agents

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“…13 Gemifloxacin and moxifloxacin show outstanding clearance of respiratory tract infections, methicillin-susceptible Staphylococcus infections, and Gram-negative bacterial infections. 5 This class of drug is also used to treat invasive gastrointestinal tract infections and moderate-to-severe enteric infections.…”

Section: Commonly Treated Infectionsmentioning

confidence: 99%

“…The broad-spectrum antimicrobial nature of fluoroquinolones has led to their use in a wide variety of microbiological infections, including gonorrhoea and uncomplicated urinary tract infections, and in areas where b-lactamase resistance is prevalent. 13 Gemifloxacin and moxifloxacin show outstanding clearance of respiratory tract infections, methicillin-susceptible Staphylococcus infections, and Gram-negative bacterial infections. 5 This class of drug is also used to treat invasive gastrointestinal tract infections and moderate-to-severe enteric infections.…”

Section: Commonly Treated Infectionsmentioning

confidence: 99%

Plasmid-mediated quinolone resistance – current knowledge and future perspectives

et al. 2013

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Quinolones are a group of antimicrobial agents that were serendipitously discovered as byproducts of the synthesis of chloroquine. Chemical modifications, such as the addition of fluorine or piperazine, resulted in the synthesis of third- and fourth-generation fluoroquinolones, with broad-spectrum antimicrobial actions against aerobic or anaerobic, Gram-positive or Gram-negative bacteria. The efficacy and consequent widespread use of quinolones and fluoroquinolones has led to a steady global increase in resistance, mediated via gene mutations, alterations in efflux or cell membranes and plasmid-conferred resistance. The first plasmid-mediated quinolone resistance gene, qnrA1, was detected in 1998. Since then, many other genes have been identified and the underlying mechanisms of resistance have been elucidated. This review provides an overview of quinolone resistance, with particular emphasis on plasmid-mediated resistance.

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“…Older fluoroquinolones, such as norfloxacin, ciprofloxacin and ofloxacin are recognised for their high urinary concentrations and excellent cure rates in the treatment of UTIs [10]. Several of the newer fluoroquinolones (trovafloxacin, sparfloxacin, gemifloxacin and moxifloxacin) have excellent in vitro activity against uropathogens, but do not provide high levels of active drug in the urine [1].…”

Section: Discussionmentioning

confidence: 99%

Urinary concentrations and bactericidal activities of newer fluoroquinolones in healthy volunteers

Stein

Schooley

2004

International Journal of Antimicrobial Agents

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Use of Quinolones in Urinary Tract Infection and Prostatitis

Cited by 8 publications

References 92 publications

Urinary bactericidal activity, urinary excretion and plasma concentrations of gatifloxacin (400 mg) versus ciprofloxacin (500 mg) in healthy volunteers after a single oral dose

Urinary bactericidal activity, urinary excretion and plasma concentrations of gatifloxacin (400 mg) versus ciprofloxacin (500 mg) in healthy volunteers after a single oral dose

Plasmid-mediated quinolone resistance – current knowledge and future perspectives

Urinary concentrations and bactericidal activities of newer fluoroquinolones in healthy volunteers

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