2006
DOI: 10.1128/iai.00041-06
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Use of Protein Microarrays To Define the Humoral Immune Response in Leprosy Patients and Identification of Disease-State-Specific Antigenic Profiles

Abstract: Although the global prevalence of leprosy has decreased over the last few decades due to an effective multidrug regimen, large numbers of new cases are still being reported, raising questions as to the ability to identify patients likely to spread disease and the effects of chemotherapy on the overall incidence of leprosy. This can partially be attributed to the lack of diagnostic markers for different clinical states of the disease and the consequent implementation of differential, optimal drug therapeutic st… Show more

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Cited by 23 publications
(19 citation statements)
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“…Concentration values for unstimulated whole blood and PBMC cultures were typically ≤10 pg/ml. Anti-PGL-I IgM antibody levels were determined by ELISA as previously described [25]. …”
Section: Methodsmentioning
confidence: 99%
“…Concentration values for unstimulated whole blood and PBMC cultures were typically ≤10 pg/ml. Anti-PGL-I IgM antibody levels were determined by ELISA as previously described [25]. …”
Section: Methodsmentioning
confidence: 99%
“…This response is primarily directed to PGL-I but also M. leprae protein antigens can be recognized by sera from lepromatous patients (30,31). In view of this, antibody levels against the ML1419c protein were analyzed after immunisation with its HLA-A*0201-restricted nonamer (Figure 3).…”
Section: Resultsmentioning
confidence: 99%
“…Protein microarrays 131 and phage display 132 have been used for such purpose, with the potential for discovery of new disease biomarkers. As many different peptide antigens are produced by the leprosy bacterium, leading to different antigenic responses in different individuals, 133 it is likely that a multiple-target assay would improve leprosy diagnosis.…”
Section: Leprosymentioning
confidence: 99%