Use of porous hydroxylapatite blocks for augmentation of atrophic mandibles

Hupp, James R.; McKenna, S.J.

doi:10.1016/0278-2391(88)90143-7

Cited by 40 publications

(16 citation statements)

References 12 publications

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“…Despite the exceptional bony incorporation of calcium phosphate ceramics, its clinical use is limited by its fragility and the difficulty of shaping blocks or keeping the particulated ceramic together, especially in applications such as alveolar ridge augmentation or zygomatic bone reconstructions [26]. Mixing with fibrine glues [271 or collagen extracts [28] helps to some degree to overcome these difficulties, but these very high-cost additives do not bring appreciable mechanical strength to the reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study

Munting

Mirtchi

Lemaître

1993

J Mater Sci: Mater Med

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A quickly setting calcium phosphate-based hydraulic cement mixed with particles of tricalcium phosphate (TCP) ceramic was implanted in 56 metaphysial defects made in the long bones of ten adult mongrel dogs. Microradiography, histology and scanning electron microscopy (SEM) demonstrated the slow resorption of the cement and the bony incorporation of the calcium phosphate ceramic particles which were consistently embedded in bone. The original structural pattern of the bone tended to be restored 7 months after implantation. The cement did not hinder the incorporation of the calcium phosphate ceramic particles, neither did it elicit any inflammatory or foreign-body response. The cement was easily shaped and allowed a perfect filling of any defect, resulting in close contact of the whole implant surface with the host bone at the time of surgery, associated with appreciable mechanical strength. Most of the practical problems associated with the use of calcium phosphate ceramics in the repair of bone defects could be overcome with the cement.

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Section: Discussionmentioning

confidence: 99%

Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study

Munting

Mirtchi

Lemaître

1993

J Mater Sci: Mater Med

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“…Therefore, complications such as the perforation of the mucosa covering HAP used in block form and the dispersion of HAP used in granule form have been reported. 3,4 Monma and Kanazawa reported that the hydration of ␣-tricalcium phosphate occurs below 100°C in water and that the product is calcium-deficient HAP. 5 In 1986 Brown and Chow developed a calcium phosphate cement that consisted of tetracalcium phosphate and dicalcium phosphate anhydrous or dicalcium phosphate dihydrate 6 that had good osteoconductivity.…”

Section: Introductionmentioning

confidence: 99%

Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl‐chitin

Yokoyama¹,

Matsuno²,

Yamamoto³

et al. 2003

J Biomedical Materials Res

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We developed a new calcium phosphate cement containing succinic acid and carboxymethyl-chitin in the liquid component. In this study, the biocompatibility and osteoconductivity of this new cement were investigated. After mixing, cement in putty form was implanted immediately between the periosteum and parietal bone and in the subcutaneous tissues of rats. In control cement, distilled water was used instead of the liquid component. In addition to histological evaluations, analyses with X-ray diffraction and Fourier transform infrared were performed for the subcutaneously implanted cements. Histological examination showed slight inflammation around the new cement on the bone and in the subcutaneous tissue at 1 week after surgery. At 2 weeks, the cement was partially bound to the parietal bone. The extent of the surface of the new cement directly in contact with the bone increased with time, and most of the undersurface of the new cement bound to the host parietal bone by 8 weeks. Analysis by X-ray diffraction showed that the new cement in the subcutaneous tissue was transformed into hydroxyapatite by 8 weeks. These results indicate that this new calcium phosphate cement is useful as a bone substitute material.

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“…1,2 However, the use of block forms of porous HA results in an unacceptably high failure rate in clinical applications. 3 The inertness of biomaterials is relative: Even materials considered inert in bulk form are capable of eliciting inflammatory reactions in particulate form. 4 It has been recognized that particulate debris around an orthopedic implant has an adverse effect on the surrounding tisuses.…”

Section: Introductionmentioning

confidence: 99%

Influence of hydroxyapatite particle size on bone cell activities: Anin vitro study

Sun

Liu

Chang

et al. 1998

J. Biomed. Mater. Res.

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Over the past decade, a large number of biomaterials have been proposed as artificial bone fillers for repairing bone defects. The material most widely used in clinical medicine is hydroxyapatite. The aim of our investigation was to study the effect of hydroxyapatite size mechanism on osteoblasts. The osteoblasts were cultured in vitro with 0.1% (1 mg/mL) of various sized hydroxyapatite particles (0.5-3.0, 37-63, 177-250, and 420-841 microm) for 1 h, 3 h, 1 day, 3 days, and 7 days. The results showed that adding hydroxyapatite particles to osteoblast cultures can significantly affect osteoblast cell count. Osteoblast populations decreased significantly. Osteoblast mean surface areas also changed significantly. Transforming growth factor-beta1 (TGF-beta1) concentrations in culture medium decreased significantly with the addition of hydroxyapatite particles. Prostaglandin E2 (PGE2) concentrations in medium increased significantly. The changes in TGF-beta1 and PGE2 concentration were more significant and persisted longer in smaller-particle groups. The inhibitory effects of hydroxyapatite particles on osteoblast cell cultures were mediated by the increased synthesis of PGE2. Caution should be exercised before using a hydroxyapatite product which could easily break down into fine particles.

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Use of porous hydroxylapatite blocks for augmentation of atrophic mandibles

Cited by 40 publications

References 12 publications

Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study

Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study

Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl‐chitin

Influence of hydroxyapatite particle size on bone cell activities: Anin vitro study

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