Use of polyphenol-rich grape by-products in monogastric nutrition. A review

Brenes, Agustı́n; Viveros, Agustı́n; Chamorro, Susana; Arija, I.

doi:10.1016/j.anifeedsci.2015.09.016

Cited by 255 publications

(230 citation statements)

References 139 publications

Supporting

Mentioning

194

Contrasting

Unclassified

Order By: Relevance

“…2, 2′-Azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging activity assay was completed using the colorimetric method (Brenes et al, 2016). ABTS radical cation was prepared by mixing 5 mL of 7 mM ABTS solution with 45 mL of 2.45 mM K 2 S 2 O 4 solution.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, the interactions between polyphenols and other food ingredients, such as protein, fatty acid, and dietary fiber, are investigated as it might affect the bio-accessibility of polyphenols during digestion, absorption, and metabolism in human (Gleichenhagen and Schieber, 2016). The application of polyphenols is recommended to restrict the occurrence of lipoper oxidation and maintain human health (Brenes et al, 2016). Many studies have shown that polyphenols possess antioxidant property, and daily intake of polyphenols enriched diets could prevent relative diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation

et al. 2017

View full text Add to dashboard Cite

Agrimonolide and desmethylagrimonolide are the main bioactive polyphenols in agrimony with well-documented antioxidant, anti-diabetic, and anti-inflammatory potential. We report here for the first time that agrimonolide and desmethylagrimonolide stimulate the expression of phase II detoxifying enzymes through the Nrf2-dependent signaling pathway. Agrimonolide and desmethylagrimonolide also possess considerable protective activity from oxidative DNA damage. In order to explore the cytoprotective potential of agrimonolide and desmethylagrimonolide on oxidative stress in liver, we developed an oxidative stress model in HepG2 cells, and check the hypothesis whether Nrf2 pathway is involved. Western blotting and luciferase assay revealed that exposure of HepG2 cells to agrimonolide or desmethylagrimonolide leads to increased heme oxygenase-1 (HO-1) expression by activating ARE through induction of Nrf2 and suppression of Kelch-like ECH-associated protein 1 (Keap1). Moreover, agrimonolide and desmethylagrimonolide also activated ERK signaling pathways and significantly attenuated individual p38 MAPK expression, subsequently leading to Nrf2 nuclear translocation. In conclusion, our results indicated that transcriptional activation of Nrf2/ARE is critical in agrimonolide and desmethylagrimonolide-mediated HO-1 induction, which can be regulated partially by the blockade of p38 MAPK signaling pathway and inhibiting nuclear translocation of Nrf2.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation

et al. 2017

View full text Add to dashboard Cite

show abstract

“…These by-products are rich in a wide range of polyphenols like flavonoids, monomeric phenolic compounds, catechins, and epicatechins (Dorri et al, 2012). The grape polyphenols could act as powerful antioxidants by scavenging free-radicals and terminating oxidative reactions (Brenes et al, 2016). During the processing of grapes, economical, and ecological problems are caused by a large volume of produced residues.…”

Section: Introductionmentioning

confidence: 99%

Effects of grape pomace and vitamin E on performance, antioxidant status, immune response, gut morphology and histopathological responses in broiler chickens

Ebrahimzadeh¹,

Navidshad²,

Farhoomand³

et al. 2018

SA J. An. Sci.

View full text Add to dashboard Cite

We investigated the effects of grape pomace (GP) and vitamin E on the performance, antioxidant status, immune response, gut morphology and histopathological responses in broiler chickens. Two hundred and fifty male broiler chickens (Ross 308) were allocated to five dietary treatments (50 birds/treatment) in a completely randomized design. The experimental diets were as follows: i) Control corn-soybean meal diet (C); ii) C + Vitamin E (200 mg/kg of α-tocopherol acetate); iii) The diet containing 5%GP; iv) The diet containing 7.5% GP; v) The diet containing 10% GP. No differences were found in performance of the experimental birds. Birds fed 7.5% GP showed a significant increase in superoxide dismutase (SOD), glutathione peroxidise (GSH-Px) activity and reduced malondialdehyde (MDA) concentration. Antibody titer against Newcastle disease virus (NDV) at 42 days (d) of age in the control and 7.5% GP fed groups were lower than others. The primary IgM concentration of birds fed 10% GP was higher than the birds fed the control diet, the vitamin E supplemented diet or the diet containing 5% GP. The secondary titer against sheep red blood cells (SRBC) was increased significantly in the birds fed 10% GP and the secondary IgG concentration of birds fed 10% GP was higher than the birds fed the control diet and the diets containing 5% or 7.5% GP. In duodenum part of small intestine, villus height/crypt depth ratio and muscularis thickness were decreased. The results of the present study suggest that the inclusion of up to 10% GP in diets did not adversely affect broiler chickens' performance and improved the antioxidant and immune responses of broiler chickens. ______________________________________________________________________________________

show abstract

“…Studies have shown that the pomace represents, in general, 20–30% of initial grape weight . Grape seeds comprise 38% to 52% of the grape pomace, on a dry mater basis, being characterized as a complex matrix composed of approximately 40% fiber, 16% oil, 11% protein, and other components including phenolic compounds, sugars and minerals . According to the scientific literature, grape seeds are a rich source of natural antioxidants and their extracts have different health benefits …”

Section: Introductionmentioning

confidence: 99%

Grape seed pomace as a valuable source of antioxidant fibers

et al. 2019

View full text Add to dashboard Cite

BACKGROUND Grape seed pomace is a valuable by‐product from winery/oil extraction industries and a potential source of bioactive compounds. Hot water extraction is the most widely used technology for polysaccharide recovery from plant and seed sources. To obtain an antioxidant fiber‐rich extract (AFE) from defatted grape seed pomace, seed:water ratio (1:10–1:20) and extraction temperature (70–90 °C) effects on extraction yield, total sugars, total phenolic compounds and condensed tannins were investigated. RESULTS The best extraction results were achieved at the highest seed:water ratio and temperature. At these conditions, the extraction yield and total sugar content of the freeze‐dried AFE were 100.1 g kg−1 and 725.3 g kg−1, respectively. The AFE presented high total phenolic content (16.2 g GAE kg−1), condensed tannins (515.1 mg CAT kg−1), soluble (219.1 g kg−1) and insoluble fibers (132.4 g kg−1), besides protein (171.1 g kg−1) and ash (152.6 g kg−1). The antioxidant capacity of the AFE was 382.7, 823.7 and 1439.4 μmol Trolox g−1 for DPPH, ABTS and ORAC methods. CONCLUSION The AFE was shown to be not only an interesting source of fiber with antioxidant capacity, which could become a potential foodstuff, but also an ecofriendly and sustainable alternative to use grape seed pomace. © 2019 Society of Chemical Industry

show abstract

Use of polyphenol-rich grape by-products in monogastric nutrition. A review

Cited by 255 publications

References 139 publications

Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation

Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation

Effects of grape pomace and vitamin E on performance, antioxidant status, immune response, gut morphology and histopathological responses in broiler chickens

Grape seed pomace as a valuable source of antioxidant fibers

Contact Info

Product

Resources

About