Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

Abstract

We evaluated the efficacy of pineapple juice with gadopentetate dimeglumine as a negative oral contrast agent for magnetic resonance cholangiopancreatography (MRCP). Images were obtained before and after the intake of a negative oral contrast agent. Images obtained from six different areas of the biliary tree were analyzed by three different radiologists, who were blind to the exams; scores regarding image quality were given to each area. The statistical analysis showed a significant difference between images before and after the use of the contrast agent (P < 0.001) for the three radiologists (R1-R3). Mean scores given by radiologists before the intake of the contrast agent were 2.49 ± 0.42 (R1), 2.62 ± 0.32 (R2), and 2.22 ± 0.46 (R3). After the intake, mean scores were 3.38 ± 0.62 (R1), 3.48 ± 0.55 (R2), and 2.89 ± 0.69 (R3). The ducts that showed the highest scores were the common bile duct and duct of Wirsung, the distal portion of the common bile duct and the cystic duct. We suggest herein that the contrast agent pineapple juice with gadopentate dimeglumine constitutes an efficient negative oral contrast agent for MRCP, for it efficiently eliminates the signal of the digestive tube in MRCP images.

Aplicação De Image J® Para Imagens Em Colangiopancreatografia Por Ressonância Magnética

“…O uso de contraste natural, como o suco de algumas frutas, é mais indicado por não ocasionar reações adversas e apresentar uma imagem similar ao comercial [4]. O suco como agente de contraste deve conter material paramagnético; atuar como contraste bifásico (mostrar-se positivo nas sequências em T1 e negativo em T2); distribuir-se uniformemente na cavidade digestiva e no intestino delgado; não ser tóxico e ter custo acessível [4,5]. Metais como ferro (Fe) e manganês (Mn) estão presentes em sucos de abacaxi, mirtilo (blueberry) e açaí [6,7].…”

“…Escore 2: avaliação se dá parcialmente quando visualizam-se as estruturas. No escore 3 a hiperintensidade do sinal não dificulta a análise das estruturas, e no escore 4 não existe uma hiperintensidade de sinal entre o estômago e duodeno, o que torna o exame de CPRM mais nítido e com melhor qualidade [5].…”

Fluid filling of the digestive tract for improved proton resonance frequency shift‐based MR thermometry in the pancreas

“…To manipulate the susceptibility distribution inside the digestive cavities surrounding the pancreas, an attempt was made to fill these by oral fluid intake. 13,14 Pineapple juice was chosen for this purpose with the intent to reduce susceptibility differences inside the digestive tract and to match the relaxation time constants of the surrounding tissues (T 1 5 243 msec, T 2 5 48 msec, at 1.5T). 15 To assess the time needed to obtain an increased signal in the transverse colon after oral intake of half a liter of juice, a pilot experiment was performed in two of our volunteers.…”

Açai juice as contrast agent in MRCP exams: qualitative and quantitative image evaluation

“…Although there are papers about the use of juices as MRCP contrast agents [3,4], it was not found publications about standardization procedure and administration protocol of the juices [4,5]. Image evaluation is achieved from several ways in clinics and hospitals by means of medical analysis or using some computational tool [10,11,12]. These can help to identify lesions, tumors or alteration of the organ or tissue being examined.…”