Use of Physiologic and Arterial Blood Gas Variables to Predict Short‐Term Survival in Horses with Large Colon Volvulus

Kelleher, Maureen E.; Brosnan, Robert J; Kass, Philip H.; Jeune, Sarah S. le

doi:10.1111/j.1532-950x.2012.01081.x

Cited by 23 publications

(30 citation statements)

References 20 publications

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“…Documentation of this association reinforces the importance of reduced presurgical treatment colic duration as it affects survival in horses with large colon volvulus, and focuses future education on timely referral and its positive impact on colic treatment outcomes . Other identified factors associated with survival rate in the present study, including PCV at admission , surgical duration , operative hypotension , and post operative heart rate and manure consistency , have been similarly observed in other reports.…”

Section: Discussionsupporting

confidence: 86%

Duration of disease influences survival to discharge ofThoroughbred mares with surgically treated large colon volvulus

Hackett

Embertson

Hopper

et al. 2014

Equine Veterinary Journal

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Section: Discussionsupporting

confidence: 86%

Duration of disease influences survival to discharge ofThoroughbred mares with surgically treated large colon volvulus

Hackett

Embertson

Hopper

et al. 2014

Equine Veterinary Journal

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“…Increased PCV at admission was associated with nonsurvival in horses with LCV, as was the case in other studies . Increased PCV is reflective of the duration of the colic and the degree of systemic compromise of the horse .…”

Section: Discussionsupporting

confidence: 76%

“…Strangulating large colon volvulus (LCV) is a serious manifestation of colic that has been classically associated with mortality rates of 35% to 86% . However, an 88% survival to discharge has been described that was attributed to early recognition and prompt surgical intervention .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus

et al. 2020

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Objective To determine the prognostic value of (1) colonic venous lactate or peripheral lactate values obtained before and after manual correction of a large colon volvulus and (2) a combination of variables including pelvic flexure biopsy. Study design Prospective clinical study. Animals Forty adult horses in which large colon volvulus was diagnosed intraoperatively. Methods Colonic venous, peripheral venous, and arterial blood samples were collected to measure lactate values before and after manual correction. Mucosal biopsy samples were obtained in cases that underwent enterotomy or colonic resection and anastomosis. Interstitium to crypt (I:C) ratio and hemorrhage scores were measured. Optimal cutoff values were determined by receiver operator curve analysis, and associations between variables and short‐term outcome were determined by univariable regression. Short‐term survival was defined as horses being discharged from the hospital. P ≤ .05 was considered significant. Results No association was found between colonic venous lactate values before (P = .011) or after (P = .201) manual correction of large colon volvulus and determination of short‐term outcome. Peripheral venous lactate at admission ≥3.2 mmol/L and after manual correction ≥5 mmol/L, arterial lactate postmanual correction ≥3.53 mmol/L, and histomorphometric measurements of mucosal hemorrhage ≥3 and I:C ratio > 1 were associated with poor short‐term outcome. Conclusion Peripheral lactate values, histomorphometric measures of I:C ratio, and hemorrhage score provided prognostic information that could help guide recommendations made to owners. Clinical significance Peripheral lactate values after manual correction provide important intraoperative diagnostic information to assist in predicting case outcome in the operative and immediately postoperative period.

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“…Blood lactate was not associated with RA in either the univariable or the final multivariable analysis. Previous studies have reported on the value of RATIOL and DIFL for prediction of survival in horses with colic. Increased peritoneal fluid to blood lactate ratio has also been associated with strangulating SI lesions compared with nonstrangulating lesions .…”

Section: Discussionmentioning

confidence: 99%

Preoperative factors associated with resection and anastomosis in horses presenting with strangulating lesions of the small intestine

Pye

Espinosa‐Mur

Roca³

et al. 2019

Veterinary Surgery

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Objective To determine if preoperative and intraoperative clinical variables correlate with resection and anastomosis (RA) in horses presenting with strangulating small intestinal (SI) lesions. Study design Retrospective case series. Animals Horses undergoing exploratory celiotomy for a strangulating SI lesion (n = 243). Methods The records of horses undergoing surgical correction for strangulating SI lesions from January 1, 2000 to December 31, 2017 were reviewed. Horses were categorized as treated with RA or not treated with RA. Obtained information included history, signalment, clinical findings, diagnostic test results, intraoperative findings, and survival to discharge. Univariable and multivariable analyses were used to compare data between horses treated with RA vs those not treated with RA (P = .05). Results In total, 172 SI lesions were resected, and 71 were not resected. Horses that had gastric reflux at admission to the hospital (odds ratio [OR] 5.56; 95% CI 1.76, 17.59) and horses with amotile SI according to abdominal ultrasonography (OR 9.69; 95% CI 3.09, 30.37) were more likely to undergo RA. Increased difference between peritoneal fluid and blood lactate was higher in horses that underwent RA (OR 1.55; 95% CI 1.12, 2.13). Survival to hospital discharge was lower in the group of horses that underwent RA compared with horses that did not undergo RA. Conclusion Resection and anastomosis of strangulating SI lesions was associated with several preoperative variables. Clinical significance This study highlights the value of preoperative diagnostic procedures in aiding intraoperative decision making and prognostication in horses presenting with strangulating SI lesions.

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Use of Physiologic and Arterial Blood Gas Variables to Predict Short‐Term Survival in Horses with Large Colon Volvulus

Cited by 23 publications

References 20 publications

Duration of disease influences survival to discharge ofThoroughbred mares with surgically treated large colon volvulus

Duration of disease influences survival to discharge ofThoroughbred mares with surgically treated large colon volvulus

Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus

Preoperative factors associated with resection and anastomosis in horses presenting with strangulating lesions of the small intestine

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