Use of Outpatient Parenteral Antimicrobial Therapy for Transrectal Ultrasound-guided Prostate Biopsy Prophylaxis in the Setting of Community-associated Multidrug-resistant Escherichia coli Rectal Colonization

Recommendations for outpatient parenteral antimicrobial therapy in Brazil

“…Patients with diagnoses of the infections described below are considered eligible for treatment under an OPAT regimen: Complicated upper respiratory tract infections, including malignant external otitis, necrotizing external otitis and rhinosinusitis 8 , 9 , 10 , 11 ; Respiratory infections, including complicated pneumonias, empyemas, lung abscesses, cystic fibrosis, exacerbations of the conditions of chronic obstructive pulmonary disease (COPD), infected bronchiectasis, community-acquired pneumonia, and nosocomial pneumonia 12 ; Microbiologically-proven endocarditis due to Streptococcus viridians 13 , 14 in patients who do not present signs of possible complications of infectious endocarditis or predictors of poor prognosis. Patients with conditions related to other agents or without microbiological proof are not considered eligible for OPAT in Brazil; Complicated infections of the urinary tract 15 , 16 ; Intra-abdominal infections, including secondary peritonitis, abscess, sepsis, cholecystitis with perforation or abscess, intra-abdominal abscess, appendicitis with perforation or abscess, stomach or intestinal perforation, peritonitis, diverticulitis with perforation, peritonitis or abscess. 17 , 18 Patients are considered eligible for OPAT when they have stabilized and do not require new surgical interventions; Skin and soft-tissue infections, including cellulitis, large abscesses, surgical wound infections, infected burns, infected ulcers, infected bites and pyomyositis.…”

Application of Prostate Ultrasound for Prostate Biopsy

“…Prophylactic antibiotic use may need to be modifi ed based on local patterns of bacterial resistance. Shakil et al evaluated the use of outpatient parenteral prophylaxis with ertapenem for multidrug-resistant E. coli rectal colonization identifi ed on rectal swab cultures [ 12 ]. All patients received ertapenem one day prior to and on the day of biopsy with no infectious complications.…”