Use of Newcastle Disease Virus Vaccine (MTH-68/H) in a Patient With High-grade Glioblastoma

Csatary, Laszlo K.; Bakács, Tibor

doi:10.1001/jama.281.17.1588-a

Cited by 85 publications

(59 citation statements)

References 4 publications

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“…The ability of NDV to directly replicate in and kill a variety of cultured human and rat neuroblastoma cells without effect in normal fibroblasts has been previously described [31]. Csatary [32] reported that both pediatric and adult patients suffering from high grade glioma, and anecdotal evidence of efficacy in some patients was noted. Elsewhere a case report of a fourteen year old patient suffering from recurrent GBM was treated by IV administration of NDV.…”

Section: Cancer Therapy Using Oncolytic Virusesmentioning

confidence: 90%

“…The last published report of this patient indicated that he was taking only NDV vaccine treatment and was living a relatively normal life. The NDV strain HuJ was tested for safety and efficacy in a phase trials and Intravenous administration of NDV was well tolerated and maximum tolerable dose (MTD) was not reached in this study [32]. III.…”

Section: Cancer Therapy Using Oncolytic Virusesmentioning

confidence: 99%

“…In gene therapy, expression of therapeutic foreign gene products either directly or indirectly leads to cell death [32].…”

Section: Cancer Therapy Using Oncolytic Virusesmentioning

confidence: 99%

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Current Advancements on the Significance of Oncolytic Viruses in the Treatment of Tumor Cells

Demeke¹,

Tassew²

2016

J Veterinar Sci Technol

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The occurrence and severity of tumor, which is caused by many factors and etiological agents, become rapid and its distribution is worldwide that lead to death of many individuals. In order to avoid associated complications scientists discovered a means for the removal of tumor using oncolytic virus called virotherapy. This review is aiming to give highlight about the current advancements on the significance of oncolytic viruses in the treatment of tumor cells. Oncolytic viruses carry the promise to efficiently target cancer cells for destruction and spread throughout tumor tissue to reach distant loci without causing collateral damage to healthy tissues. Current oncolytic virotherapy strategies are based on the common molecular mechanisms of viral infection and cell transformation, like apoptotic dysregulation and cell cycle disruption. In this regards this time scientists is being done active research to improve the accessibility, safety and efficacy of oncolytic virotherapy.

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Section: Cancer Therapy Using Oncolytic Virusesmentioning

confidence: 90%

Section: Cancer Therapy Using Oncolytic Virusesmentioning

confidence: 99%

See 1 more Smart Citation

Current Advancements on the Significance of Oncolytic Viruses in the Treatment of Tumor Cells

Demeke¹,

Tassew²

2016

J Veterinar Sci Technol

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“…60 Regression of a glioblastoma in a boy has been reported after daily IV administration of live NDV MTH-68. 55 In a placebo-controlled study 54 of 59 patients with advanced cancers, twice weekly inhalation therapy with live MTH-68 induced regression and no progression or malignant tumor stabilization in 18 patients (55%) of the NDV-treated group, compared with only 2 patients (8%) with similar favorable results in the placebo-treated controls. The mechanism for NDV oncolytic activity is unknown, but NDV has been shown to be a potent inducer of α α tumor necrosis factor (TNF-α α) production by human peripheral blood mononuclear cells and enhance sensitivity of the tumor cells to the cytolytic effect of TNF-α.…”

Section: Newcastle Disease Virus As Cancer Therapy For Humansmentioning

confidence: 98%

“…Because of the mild, self-limited infection of humans by NDV, the risk of substantial illness and pandemics is unlikely. Multiple treatments of humans with NDV administered by inhalation 54 or IV 55 without substantial adverse effects are further evidence that the risk of severe illness is low, although low-grade fevers that subsided in 24 hours did occur after inhalation therapy in 8 of 23 vaccine-treated patients. In the inhalation studies, it was also noted that mild conjunctivitis was a consequence of accidental eye inoculation.…”

Section: Clinical Disease In Humansmentioning

confidence: 99%

Avian influenza and Newcastle disease

Swayne¹,

King²

2003

javma

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The recombinant Newcastle disease virus Anhinga strain expressing human TRAIL exhibit antitumor effects on a glioma nude mice model

et al. 2020

Journal of Medical Virology

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Oncolytic virus therapy is perhaps the next major breakthrough in cancer treatment following the success in immunotherapy using immune checkpoint inhibitors. However, the potential oncolytic ability of the recombinant newcastle disease virus (NDV) Anhinga strain carried with tumor necrosis factor‐related apoptosis inducing ligand (TRAIL) has not been fully explored at present. In the present study, the recombinant NDV/Anh‐TRAIL that secretes soluble TRAIL was constructed and the experiment results suggested NDV/Anh‐TRAIL as a promising candidate for glioma therapy. Growth kinetic and TRAIL secreted quantity of recombinant NDV/Anh‐TRAIL virus were measured. Cytotoxic and cell apoptosis were analyzed for its anti‐glioma therapy in vitro. Nude mice were used for the in vivo evaluation. Both tumor volume and mice behavior after injection were observed. The recombinant virus replicated with the same kinetics as the parental virus and the highest expression of TRAIL (77.8 ng/L) was found at 48 hours. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, a tetrazole and flow cytometry data revealed that the recombinant NDV/Anh‐TRAIL (56.1 ± 8.2%) virus could induce a more severe apoptosis rate, when compared with the NDV wild type (37.2 ± 7.0%) and mock (7.0 ± 1.8%) groups (P < .01), in U251 cells. Furthermore, in the present animal study, the average tumor volume was smaller in the NDV/Anh‐TRAIL group (97.21 mm3), when compared with the NDV wild type (205.03 mm3, P < .05) and PBS (310.30 mm3, P < .01) groups.

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Use of Newcastle Disease Virus Vaccine (MTH-68/H) in a Patient With High-grade Glioblastoma

Cited by 85 publications

References 4 publications

Current Advancements on the Significance of Oncolytic Viruses in the Treatment of Tumor Cells

Current Advancements on the Significance of Oncolytic Viruses in the Treatment of Tumor Cells

Avian influenza and Newcastle disease

The recombinant Newcastle disease virus Anhinga strain expressing human TRAIL exhibit antitumor effects on a glioma nude mice model

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