Use of N-butyl cyanoacrylate in nasal septoplasty: histopathological evaluation using rabbit nasal septum model

Abstract

In this rabbit septoplasty model, N-butyl cyanoacrylate appeared to be an effective nasal tissue adhesive, with a low complication rate.

Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation

“…This inflammatory reaction was also seen in the defect without glue treatment, suggesting that the reaction was primarily caused not by the glue but by the scaffold and outer annulus self‐repair process. Our results are consistent with studies using butyl cyanoacrylate glue in nasal spine and facial bone repair, where no significant difference of infection, foreign body reaction, necrosis, or histotoxicity was observed between groups with and without glue . There are also studies showing cyanoacrylate associated with tissue necrosis and strong inflammatory reaction .…”

“…Although they were very effective, the degradation products had significant tissue toxicity at that time . Over time, newer commercial products with better biocompatibility have emerged, for example, butyl cyanoacrylate (LiquiBand, Histoacryl), octyl cyanoacrylate (Dermabond, SurgiSeal), or blends of both (LiquiBand) . However, negative effects on cell‐ and tissue viability continue to emphasize the fact that application of this kind of glue in soft tissues was questionable and required individual evaluations .…”

“…Our results are consistent with studies using butyl cyanoacrylate glue in nasal spine and facial bone repair, where no significant difference of infection, foreign body reaction, necrosis, or histotoxicity was observed between groups with and without glue. 28,29 There are also studies showing cyanoacrylate associated with tissue necrosis 21 and strong inflammatory reaction. 22 However, these negative responses were speculated to be related both to the exothermic effect during glue polymerization in a too moist environment and to the large amount of glue applied.…”

In vitro and in vivo studies on the use of Histoacryl® as a soft tissue glue

“…Another work discussing the use of Histoacryl ® in septorhinoplasty was published in 2010 by Aksoy et al The authors investigated eVects of Histoacryl ® on the nasal septum on 42 rabbits and found a good biocompatibility with moderate foreign body reactions [16].…”

Desenvolvimento de um sistema minimamente invasivo para monitorar a pressão intracraniana

“…A cola já foi bastante utilizada em diversos experimentos biológicos e até mesmo em alguns processos cirúrgicos humanos [52][53][54][55] . Nós utilizamos esta cola para os testes iniciais, migrando para outro derivado do cianoacrilato, de nome comercial Hystoacril (n-butil-cianoacrilato) para a futura utilização em humanos [56][57][58] .…”