In vitro and in vivo studies on the use of Histoacryl® as a soft tissue glue

Schneider, G; Otto, K

doi:10.1007/s00405-011-1868-4

Cited by 16 publications

(27 citation statements)

References 31 publications

(37 reference statements)

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“…Over time, newer commercial products with better biocompatibility have emerged, for example, butyl cyanoacrylate (LiquiBand, Histoacryl), octyl cyanoacrylate (Dermabond, SurgiSeal), or blends of both (LiquiBand) . However, negative effects on cell‐ and tissue viability continue to emphasize the fact that application of this kind of glue in soft tissues was questionable and required individual evaluations . These lead to questions whether the glue as an off‐label soft tissue adhesive is biocompatible to the specific regenerative cell source hMSC and the specific annulus tissue in the goal of annulus repair.…”

Section: Discussionmentioning

confidence: 99%

“…There are also studies showing cyanoacrylate associated with tissue necrosis and strong inflammatory reaction . However, these negative responses were speculated to be related both to the exothermic effect during glue polymerization in a too moist environment and to the large amount of glue applied . In our study, a small amount of glue and a relatively dry application area slowed down the heating up, minimizing the exothermic side effect.…”

Section: Discussionmentioning

confidence: 99%

“…Inspired from these previous studies, medical glue might also be applied for the repair of annulus defect. On the other hand, there are reservations concerning the glue's biocompatibility . A recent study indicated that choosing cyanoacrylate glue as the appropriate choice should be based on individual evaluation of the tissue involved, purpose served by applying the glue, and amount of glue applied …”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, there are reservations concerning the glue's biocompatibility. [21][22][23] A recent study indicated that choosing cyanoacrylate glue as the appropriate choice should be based on individual evaluation of the tissue involved, purpose served by applying the glue, and amount of glue applied. 21 We previously developed a polycaprolactone (PCL) scaffold with a three-dimensional, nanofibrous, multilamellar structure mimicking native annulus architecture specifically for annulus repair.…”

Section: Introductionmentioning

confidence: 99%

“…[21][22][23] A recent study indicated that choosing cyanoacrylate glue as the appropriate choice should be based on individual evaluation of the tissue involved, purpose served by applying the glue, and amount of glue applied. 21 We previously developed a polycaprolactone (PCL) scaffold with a three-dimensional, nanofibrous, multilamellar structure mimicking native annulus architecture specifically for annulus repair. 24 In quest for a proper closure method, to our knowledge, neither the ability of cyanoacrylate glue together with a scaffold to provide an effective sealing effect in the defect nor the glue's biocompatibility to such specific regenerative cell sources as human mesenchymal stem cell (hMSC) and specific annulus tissue have been adequately studied.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation

Kang

Lysdahl

et al. 2015

J Biomed Mater Res

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In an attempt to find an ideal closure method during annulus defect repair, we evaluate the use of medical glue by mechanical and biocompatible test. Cyanoacrylate medical glue was applied together with a multilayer microfiber/nanofiber polycaprolactone scaffold and suture in annulus repair. Continuous axial loading and fatigue mechanical test was performed. Furthermore, the in vitro response of mesenchymal stem cell (MSC) to the glue was evaluated by cell viability assay. The in vivo response of annulus tissue to the glue and scaffold was also studied in porcine lumbar spine; histological sections were evaluated after 3 months. Cyanoacrylate glue significantly improved the closure effect in the experimental group with failure load 2825.7 ± 941.6 N, compared to 774.1 ± 281.3 N in the control group without glue application (p < 0.01). The experimental group also withstood the fatigue test. No toxic effect was observed by in vitro cell culture and in vivo implantation. On the basis of this initial evaluation, the use of cyanoacrylate medical glue improves closure effect with no toxicity in annulus defect repair. This method of annulus repair merits further effectiveness study in vivo. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 14-20, 2017.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation

Kang

Lysdahl

et al. 2015

J Biomed Mater Res

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Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches Using Visible Light Initiated Thiol–Ene Coupling Chemistry

Granskog

Andrén

Cai

et al. 2015

Adv Funct Materials

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A library of dendritic–linear–dendritic (DLD) materials comprising linear poly(ethylene glycol) and hyperbranched dendritic blocks based on 2,2‐bis(hydroxymethyl) propionic acid is successfully synthesized and postfunctionalized with peripheral allyl groups. Reactive DLDs with pseudo‐generations of 3 to 6 (G3‐G6) are isolated in large scale allowing their thorough evaluation as important components for the development of biomedical adhesives. Due to their branched nature and inherent degradable ester‐bonds, promising biomaterial resins are accomplished with suitable viscosity, eliminating the excessive use of co‐solvents. By utilizing benign high‐energy visible light initiated thiol–ene coupling chemistry, DLDs together with tris[2‐(3‐mercaptopropionyloxy)ethyl] isocyanurate and surgical mesh enable the fabrication of soft tissue adhesive patches (STAPs) within a total irradiation time of 30 s. The STAPs display the ability to create good adhesion to wet soft tissue and encouraging results in cytotoxicity tests. All crosslinked materials are also found to degrade after being stored in human blood plasma and phosphate buffered saline. The proposed benign methodology coupled with the promising features of the crosslinked materials is herein envisioned as a soft tissue adhesive with properties that do not exist in currently available tissue adhesives.

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High‐Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair

Granskog

García‐Gallego

Kieseritzky

et al. 2018

Adv Funct Materials

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The use of adhesives for fracture fixation can revolutionize the surgical procedures toward more personalized bone repairs. However, there are still no commercially available adhesive solutions mainly due to the lack of biocompatibility, poor adhesive strength, or inadequate fixation protocols. Here, a surgically realizable adhesive system capitalizing on visible light thiol-ene coupling chemistry is presented. The adhesives are carefully designed and formulated from a novel class of chemical constituents influenced by dental resin composites and self-etch primers. Validation of the adhesive strength is conducted on wet bone substrates and accomplished via fiber-reinforced adhesive patch (FRAP) methodology. The results unravel, for the first time, on the promise of a thiol-ene adhesive with an unprecedented shear bond strength of 9.0 MPa and that surpasses, by 55%, the commercially available acrylate dental adhesive system Clearfil SE Bond of 5.8 MPa. Preclinical validation of FRAPs on rat femur fracture models details good adhesion to the bone throughout the healing process, and are found biocompatible not giving rise to any inflammatory response. Remarkably, the FRAPs are found to withstand loads up to 70 N for 1000 cycles on porcine metacarpal fractures outperforming clinically used K-wires and match metal plates and screw implants.

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In vitro and in vivo studies on the use of Histoacryl® as a soft tissue glue

Abstract: The skin adhesive Histoacryl ® consists of n-butyl-2-cyanoacrylate which polymerises in contact with moisture.

Cited by 16 publications

References 31 publications

Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation

Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation

Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches Using Visible Light Initiated Thiol–Ene Coupling Chemistry

High‐Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair

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