Use of multifocal ERG and OCT for diagnosing Stargardt's disease

Vollmer, Lori; Shechtman, Diana; Woods, Albert D.; Pizzimenti, Joseph

doi:10.1111/j.1444-0938.2010.00527.x

Cited by 3 publications

(3 citation statements)

References 12 publications

(46 reference statements)

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“…Today, mfERG is widely used in our field, with applications in retinal disease ranging from retinal dystrophies to diabetic retinopathy [ 3 , 6 , 7 , 9 ]. For many years, researchers have studied various methods of filtering raw mfERG data, including spatial averaging, data smoothing, and pre-recording data modifiers [ 11 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…As early as 1999, Maturi et al demonstrated decreased retinal responses indicating photoreceptor damage in hydroxychloroquine toxicity, eventually becoming part of the American Academy of Ophthalmology’s official screen guidelines [ 4 , 5 ]. Some of the earliest uses of mfERG were in retinal dystrophies such as Stargard [ 6 ] and retinitis pigmentosa [ 7 ]. In today’s world, the clinical application of mfERG testing continues to grow and expand.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Smoothing and Adaptive Filtering in Multifocal Electroretinography (mfERG)

Long

Ameri

2023

JCM

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(1) Background: mfERG testing is used to study the function of cone photoreceptors in the central retina. Various filters including “smoothing” (Smooth) and “adaptive data filtering” (Adapt) are used to simplify raw data. This study will seek to characterize the effect of data modification on raw patient data. (2) Methods: This was a retrospective study of patients with mfERG results at our institution. For each patient, raw mfERG data without filtering, with smooth level 4 modifier applied, and with adapt level 4 applied were collected and compared. (4) Conclusions: In all patients, smoothing and adaptive filter modifiers create statistically significant differences in both P1 latency and P1 amplitude values when compared to raw data. The impacts of these filters demonstrated in this study should impact physicians’ decision making when interpreting mfERG results.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Smoothing and Adaptive Filtering in Multifocal Electroretinography (mfERG)

Long

Ameri

2023

JCM

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“…[ 9 ] On the other hand, the clinical finding includes macular changes with progression toward a beaten bronze maculopathy, (fishtail) pisciform flecks, macular atrophy without dots, bull’s eye maculopathy, fundus flavimaculatus (retinal spots without macular atrophy), rod-cone dystrophy, retinitis pigmentosa, and end-stage fundus aspect by extensive RPE changes, choriocapillaris atrophy, with resorbed flecks and sparse pigmentation. [ 7 , 8 , 10 , 11 ]…”

mentioning

confidence: 99%

Clinical profile and demographic distribution of Stargardt disease phenotypes: An Electronic medical record-driven big data analytics from a multitier eye care network

Das,

Venugopal,

Takkar

et al. 2023

Indian Journal of Ophthalmology

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Purpose: To describe the demographics and clinical profile of Stargardt disease in patients presenting a multitier ophthalmology hospital network in India. Methods: This cross-sectional hospital-based study was performed among 2,834,616 new patients presenting between August 2010 and June 2021 in our network. Patients with a clinical diagnosis of Stargardt disease in at least one eye were included as cases. The data were collected using an electronic medical record system. Results: Overall, 1,934 (0.069%) patients were diagnosed with Stargardt disease. Most of the patients were male (63.14%). The most common age group at presentation was during the second decade of life, with 626 (31.87%) patients. The overall prevalence was higher in patients from a higher socioeconomic status (0.077%), in those presenting from the urban geography (0.079%), and in students (0.197%). Systemic history of hypertension was seen in 56 (2.85%) patients, while diabetes mellitus was seen in (2.49%) patients. Of the 3,917 eyes, 1,910 (48.76%) eyes had moderate visual impairment (>20/70–20/200) followed by severe visual impairment (>20/200 to 20/400) in 646 (16.49%) eyes. The most commonly associated retinal signs were retinal flecks in 1,260 (32.17%) eyes, followed by RPE changes in 945 (24.13%) eyes. The most documented investigations were autofluorescence (39.85%), followed by optical coherence tomography (23.90). Cataract surgery was the commonest performed surgical intervention in (0.66%) eyes, followed by intravitreal injection in 4 (0.10%) eyes. The family history of parent consanguinity marriage was reported by 212 (10.79%) patients. Conclusion: Stargardt disease was seen more commonly in males presenting during the second decade of life. It is predominantly a bilateral disease, with the majority of the eyes having moderate visual impairment.

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