Use of Mometasone Furoate to Prevent Polyp Relapse After Endoscopic Sinus Surgery

Abstract

clinicaltrials.gov Identifier: NCT00731185.

Estimating the effect of nasal steroid treatment on repeat polypectomies: survival time analysis using the General Practice Research Database

“…The results showed that patients treated with an intranasal steroid had longer recurrence free survival compared to steroid non-users. Our results are broadly in agreement with a randomised controlled trial which showed that patients treated with mometasone furoate experienced longer recurrence free period (12) . In this trial, the difference in median time to recurrence of polyps between the steroid user and non-user group was 50 days in favour of steroid users.…”

Aetiology and Findings of Recurrent Chronic Rhino Sinusitis with Nasal Polyposis after Functional Endoscopic Sinus Surgery

“…Pär Stjärne et al found the recurrence occur mainly about one year after primary surgery and this result consistent with our result (17) Effect of post-operative steroid on polyp recurrence rate Esmatinia et al only 46% of patients consumed beclomethasone dipropionate, revealed the NP regrowth which was lower than the 87% of patients in placebo group that revealed recurrence of NP (12) Fandiño C. et al they found using of intranasal corticosteroid showed significant improvement in polyp score (18) Anatomical findings During examination of our patient by endoscopy and using of CT scan and intraoperative we found that some patients had anatomical variations contribute in failure of primary surgery and we documented that as an incidence in bilateral assessed sides and found:Incomplete anterior ethmoidectomy in 40%, Incomplete posterior ethmoidectomy in 36%, MMA stenosis in 30 %, Middle turbinate lateralization in 22%, Residual uncinate process in 20%, Septal deviation in 17%. Khalil et al They found residual anterior and posterior ethmoid cells in 97% and 92% of patients, respectively (96% and 92% of sides, respectively) (19) Ramadan et al reported a series of 52 patients prepared for revision FESS, among these, he observed (residual uncinate) in 15% (20) Adam S. DeConde et al mentioned that the examination of the association between surgical extent and polyp recurrence in a previous single institution cohort study found that more extensive surgery was protective against polyp recurrence (10) and this goes with our result.…”

Budesonide nasal irrigations in the postoperative management of chronic rhinosinusitis

“…A randomized, double‐blinded, placebo‐controlled trial by Rowe‐Jones et al found that patients using twice‐daily fluticasone had better symptom scores and endoscopic findings at 5‐year follow‐up. A similar study by Stjärne et al reported that mometasone spray once daily after surgery significantly prolonged the time to relapse.…”