Use of Mifepristone and Sublingual Misoprostol for Early Medical Abortion

Lin, Mau; Li, Yiu‐Tai; Chen, Fumin; Wu, Shu-Fang; Tsai, Ching-Wan; Chen, Tien-Hui; Kuo, Tsung-Cheng

doi:10.1016/s1028-4559(09)60251-5

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…The present study demonstrates that outpatient medical abortion using 200 mg mifepristone and 600 μg sublingual misoprostol is safe and effective up to 70 days after the LMP. The high success rate (99%) is similar to findings in previous studies that were conducted in the UK [17,19] and Taiwan [18] using the same regimen. Extending outpatient services to women past 49 days since the LMP did not result in increased rates of failure to return.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Prospective study of home use of mifepristone and misoprostol for medical abortion up to 10 weeks of pregnancy in Kazakhstan

Platais

Tsereteli

Grebennikova

et al. 2016

Intl J Gynecology & Obste

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Section: Discussionsupporting

confidence: 88%

“…On the basis of previous studies [16–18], an efficacy rate of 95% was expected with a 95% confidence interval (CI) of 3%. A sample of 203 women was calculated to be sufficient to assess the efficacy of the regimen.…”

Section: Methodsmentioning

confidence: 94%

Prospective study of home use of mifepristone and misoprostol for medical abortion up to 10 weeks of pregnancy in Kazakhstan

Platais

Tsereteli

Grebennikova

et al. 2016

Intl J Gynecology & Obste

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“…, Lin et al . , , Lipp ). Late‐term abortion often involves induced labour because the foetus is in a human form (Huntington ).…”

Section: Introductionmentioning

confidence: 99%

“…Medical abortion occurs in an outpatient setting. The methods for late-term abortion (i.e., during the second and third trimesters) include dilation and evacuation (D & E), systemic medication, intra-or extra-amniotic abortifacients and hysterectomy (Stubblefield et al 2004, Lin et al 2006, Lipp 2011). Late-term abortion often involves induced labour because the foetus is in a human form (Huntington 2002).…”

Section: Introductionmentioning

confidence: 99%

Concealing emotions: nurses' experiences with induced abortion care

Yang

Che

Hsieh

et al. 2016

Journal of Clinical Nursing

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The profession should promote small-group and case-study discussions, the clarification of values and reflective thinking among nurses. Continued professional education that provides stress relief will allow nurses to develop self-healing and self-care behaviours, which will enable them to overcome the fear of death while strengthening pregnancy termination counselling, leading to better quality professional care.

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“…Many studies evaluated different roots of misoprostol such as oral, vaginal, buccal and sublingual. 2 Buccal mucosa being highly vascular leads to effective absorption of…”

mentioning

confidence: 99%

A prospective study of sublingual misoprostol following mifepristone for second trimester termination of pregnancy

Gupta¹,

Banerjee²,

Pant³

2019

OBGYN

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Objectives: This prospective study was done to evaluate the effectiveness, acceptability and side effects of sublingual misoprostol for second trimester termination of pregnancy. Materials and Methods: This hospital based prospective study was conducted on 110 women for second trimester abortion from 12-20 weeks during 2012-13.The women enrolled received 200 mg mifepristone, than sublingual misoprostol 400 microgram 3 hourly for 5 doses after 48 hours. The results were expressed in terms of induction abortion interval, dosage, success rate, acceptability and side effects. Results: The mean induction-abortion interval was shorter in multigravida i.e. 3.84 ± 0.866 hours as compare to primigravida i.e. 4.54 ± 1.79 hours. Also the mean inductionabortion interval was shorter in women with period of gestation 12-16 weeks i.e. 3.98 ± 1.055 hours as compare with gestational age 17-20 weeks with induction-abortion abortion interval of 4.05 ± 1.592 hours (p=0.08, NS). The mean dose of misoprostol was lesser in multigravida i.e. 670.0 ± 189.8 µg as compare to primigravida i.e. 739.4 ± 226.3µg (p=0.2, NS). The mean dose of misoprostol required was same irrespective of gestational age i.e. 693.3 ± 178.9 µg for gestational age 12-16 weeks and 676.9 ± 244.2 µg for gestational age 17-20 weeks (p=0.07, NS). Hundred (100%) successful abortion rate was achieved with only 0.91% women required evacuation. The acceptability was 52.73%. The side effect observed was pain abdomen (26.4%), nausea/vomiting (34.5%), headache (14.5%), diarrhoea (12.7%) and fever (12.7%). Conclusion: From present study we conclude that sublingual misoprostol following mifepristone is highly efficacious method of second trimester abortion.

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Use of Mifepristone and Sublingual Misoprostol for Early Medical Abortion

Abstract: Medical abortion for early termination of pregnancy should be achieved by oral administration of mifepristone, followed by sublingual administration of misoprostol.

Cited by 11 publications

References 13 publications

Prospective study of home use of mifepristone and misoprostol for medical abortion up to 10 weeks of pregnancy in Kazakhstan

Prospective study of home use of mifepristone and misoprostol for medical abortion up to 10 weeks of pregnancy in Kazakhstan

Concealing emotions: nurses' experiences with induced abortion care

A prospective study of sublingual misoprostol following mifepristone for second trimester termination of pregnancy

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