Use of mice for initial approximation of reentry intervals into pesticide-treated fields

Guthrie, F. E.; Domanski, J. J.; Main, A. R.; Sanders, Dave; Monroe, RJ

doi:10.1007/bf01956172

Cited by 11 publications

(7 citation statements)

References 19 publications

(9 reference statements)

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“…The responses of mice exposed to 24 and 48 h field residues of parathion, methyl parathion, and azinphos-methyl on tobacco leaves (Guthrie et al, 1974) were roughly in the same range as those of unprotected animals in the present studies, and the relative potencies were similar.…”

Section: Discussionsupporting

confidence: 73%

“…Increased persistence in the field was also reported by Guthrie et al (1974); however, a lower cholinesterase response was seen for the encapsulated formulation of methyl parathion than the EC formulation. In the present work, methyl parathion EC was roughly equivalent in potency to its encapsulated counterpart.…”

Section: Discussionmentioning

confidence: 56%

“…The aim of this investigation was to characterize and evaluate a modification of the animal model for field reentry introduced by Guthrie et al (1974). The modification was designed to help approximate the variable and complex exposure determinants involved in field worker reentry and increase the precision and accuracy of the model.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, no generally accepted procedure exists for extrapolation of animal data to humans. One animal model, suggested by Guthrie et al (1974), involves exposing mice to pesticide-treated foliar samples collected at intervals after.spraying in the field, and determining cholinesterase activities after 10 h of exposure.…”

Section: Introductionmentioning

confidence: 99%

“…In the work reported here the dermal self-exposure model of Guthrie et al (1974) was modified to allow:…”

Section: Introductionmentioning

confidence: 99%

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Application of a dermal self‐exposure model to worker reentry

Skinner

Kilgore

1982

Journal of Toxicology and Environmental Health

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The dermal toxicity of five commonly used organophosphate insecticides was investigated with a mouse intermittent self-exposure model. Blood cholinesterases were monitored on d -3 and -1 before exposure and for 4--6 d during exposure to foliar residues. Responses were much greater in unmuzzled than in muzzled animals due to oral contamination. After two 10-h exposures, muzzled mice showed log-linear cholinesterase responses across a wide range of foliar pesticide concentrations. Foliar pesticide levels that caused 50% depression in plasma or red blood cell cholinesterase were determined with log-probit dose-response analysis. The greatest cholinesterase responses for both emulsifiable concentrate and encapsulated formulations were found with diazinon, followed by parathion and methyl parathion. Azinphos-methyl and mevinphos produced no significant responses in muzzled mice at maximal foliar concentrations. Symptomatology, food consumption, and body weight provided less sensitive indicators of response than cholinesterases. No consistent relation existed between the mouse intermittent self-exposure toxicities and mouse dermal LD50 values. Use of data from acutely exposed animals to predict the hazard of intermittent foliar exposure appears inadvisable.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In the work reported here the dermal self-exposure model of Guthrie et al (1974) was modified to allow:…”

Section: Introductionmentioning

confidence: 99%