Spontaneous recovery of cholinesterases after organophosphate intoxication: Effect of environmental temperature

Honkakoski, Paavo; Ryhänen, Reijo; Harri, Mikko; Ylitalo, Pauli; Hänninen,

doi:10.1007/bf01689092

Cited by 6 publications

(1 citation statement)

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“…Harris et al (1964) reported that after a single soman dose, the half-life for the return of ChE activity in the whole blood of rats was around 32 hr. Honkakoski et al (1988) reported, however, that rats (BN x F344F1 strain) had a poor ability to recover AChE; only blood and lung, but not brain, AChE showed any approach towards control values within 48 hr. They concluded further that the measurement of ChE in the whole blood may not always adequately indicate the inhibition of ChEs.…”

Section: Discussionmentioning

confidence: 95%

Acute Behavioural Effects of the Organophosphates Sarin and Soman in Rats

Nieminen

Lecklin

Heikkinen

et al. 1990

Pharmacology & Toxicology

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The effects on behaviour of single subtoxic doses of two potent organophosphorous compounds, sarin (isopropyl methylphosphonofluoridate, 12.5 and 50 micrograms/kg, intraperitoneally) and soman (pinacolyl methylphosphonofluoridate, 4 and 20 micrograms/kg, intraperitoneally) were studied in male Wistar rats. In the open field test, soman dose-dependently decreased rearing and ambulation and increased non-mobile exploration. The higher dose of sarin changed only the rearing and grooming behaviour. Sarin and soman decreased locomotor activity on the Animex for at least one hour at the beginning of the monitoring period. In the doses used, both organophosphates inhibited acetylcholinesterase (AChE) activity significantly in the blood. The results suggest that small doses of sarin and soman have inactivating effects on the behaviour of rats. Although the findings cannot be extrapolated directly to behavioural changes in man, they indicate that subtle behavioural dysfunctions could also occur in humans at exposures which do not cause acute toxicity.

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Section: Discussionmentioning

confidence: 95%